CELLULAR MEDICINE RESEARCH DIVISION

Research at the University of St Andrews School of Medicine

Our strategy

The division of cellular medicine (CMED) combines basic and clinical research with the goal of understanding the cellular and molecular basis of disease. Our interdisciplinary research uses cutting edge technology to address fundamental biomedical processes involved in health and disease.

Research advances

£15M new Artificial Intelligence centre for Scotland to innovate and transform healthcare

Scotland is to have its own £15.8m artificial intelligence health research centre, which promises to enable better patient diagnosis, treatment and outcomes.

The Industrial Centre for Artificial Intelligence Research in Digital Diagnostics, to be known as iCAIRD, brings together a pan-Scotland collaboration of 15 partners from across academia, the NHS and industry.

Professor David Harrison, Principal Investigator for the project, based in St Andrews but with visiting professorships in both Glasgow and Edinburgh, said: “I am delighted that iCAIRD has been awarded £10m from Innovate UK. With our pan-Scotland approach, we will build on existing strengths and deploy AI within NHS Scotland to transform diagnostics and healthcare in Scotland to improve outcomes for patients. Further details.

ERISM

F-actin and nuclei expression (left) and ERISM displacement map (right) at 12-day differentiation of podocytes that are in contact with each other.

N2 domain

X-ray crystal structure of the N2 domain of HRG. PDB: 4CCV

Arrested endosomal maturation in bacterial infection

Kiss1-expressing pyramidal neurons (green) and c-Fos (red) in a hippocampal section of a Kiss1-Cre mouse brain

Calcium flux in a living mouse brain section expressing a genetically encoded calcium indicator. Stimulation was performed using a pulse of hyperkalemic solution. Experiment performed by Dr Tello.

Recent publications

20 (of 136 /dk/atira/pure/researchoutput/status/published available) for Cellular Medicine Division (source: University of St Andrews PURE)
Please click title of any item for full details

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Jeremiah A. Wala, Ofer Shapira, Grace Tiao, Henrik Hornshøj, Julian M. Hess, Randi Istrup Juul, Ziao Lin, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andrés Lanzós, Carl Herrmann, Yosef E. Maruvka, Ciyue Shen, Samirkumar B. Amin, Pratiti Bandopadhayay, Johanna Bertl, Keith A. Boroevich, John Busanovich, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, David Craft, Priyanka Dhingra, Klev Diamanti, Nuno A. Fonseca, Abel Gonzalez-Perez, Qianyun Guo, Mark P. Hamilton, Nicholas J. Haradhvala, Chen Hong, Keren Isaev, Todd A. Johnson, Malene Juul, Andre Kahles, Abdullah Kahraman, Youngwook Kim, Jan Komorowski, Kiran Kumar, Sushant Kumar, Donghoon Lee, Kjong-Van Lehmann, Yilong Li, Eric Minwei Liu, Lucas Lochovsky, Keunchil Park, Oriol Pich, Nicola D. Roberts, Gordon Saksena, Steven Schumacher, Nikos Sidiropoulos, Lina Sieverling, Nasa Sinnott-Armstrong, Chip Stewart, David Tamborero, Jose M. C. Tubio, Husen Umer, Liis Uusküla-Reimand, Claes Wadelius, Lina Wadi, Xiaotong Yao, Cheng-Zhong Zhang, Jing Zhang, James E Haber, Asger Hobolth, Marcin Imielinski, Manolis Kellis, Michael S. Lawrence, Christian von Mering, Hidewaki Nakagawa, Benjamin Raphael, Mark A Rubin, Chris Sander, Lincoln Stein, Joshua M. Stuart, Tatsuhiko Tsunoda, David A. Wheeler, Rory Johnson, Jüri Reimand, Mark Gerstein, Ekta Khurana, Peter J. Campbell, Núria López-Bigas, Joachim Weischenfeldt, Rameen Berouckhim, Iñigo Martincorena, Jakob Skou Pedersen, Gad Getz, Andy Lynch
Nature 2020 vol. 578 pp. 102-111
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations Yiqun Zhang, Fengju Chen, Nuno A. Fonseca, Yao He, Masashi Fujita, Hidewaki Nakagawa, Zemin Zhang, Alvis Brazma, Samirkumar B. Amin, Philip Awadalla, Peter J. Bailey, Alvis Brazma, Angela N. Brooks, Claudia Calabrese, Aurélien Chateigner, Isidro Cortés-Ciriano, Brian Craft, David Craft, Chad J. Creighton, Natalie R. Davidson, Deniz Demircioğlu, Serap Erkek, Nuno A. Fonseca, Milana Frenkel-Morgenstern, Mary J. Goldman, Liliana Greger, Jonathan Göke, Yao He, Katherine A. Hoadley, Yong Hou, Matthew R. Huska, Andre Kahles, Ekta Khurana, Helena Kilpinen, Jan O. Korbel, Fabien C. Lamaze, Kjong Van Lehmann, Chang Li, Siliang Li, Xiaobo Li, Xinyue Li, Dongbing Liu, Fenglin Liu, Xingmin Liu, Maximillian G. Marin, Julia Markowski, Matthew Meyerson, Tannistha Nandi, Morten Muhlig Nielsen, Andy Lynch
Nature Communications 2020 vol. 11
Ovarian hormones induce de novo DNA methyltransferase expression in the Siberian hamster suprachiasmatic nucleus C. S. Coyle, F. Caso, E Tolla, P. J. Barrett, K. G. Onishi, Javier Ananda Tello, T. J. Stevenson
Journal of Neuroendocrinology 2020 vol. 32
Pan-cancer analysis of whole genomes Peter J. Campbell, Gad Getz, Jan O. Korbel, Joshua M. Stuart, Jennifer L. Jennings, Lincoln D. Stein, Marc D. Perry, Hardeep K. Nahal-Bose, B. F.Francis Ouellette, Constance H. Li, Esther Rheinbay, G. Petur Nielsen, Dennis C. Sgroi, Chin Lee Wu, William C. Faquin, Vikram Deshpande, Paul C. Boutros, Alexander J. Lazar, Katherine A. Hoadley, David N. Louis, L. Jonathan Dursi, Christina K. Yung, Matthew H. Bailey, Gordon Saksena, Keiran M. Raine, Ivo Buchhalter, Kortine Kleinheinz, Matthias Schlesner, Junjun Zhang, Wenyi Wang, David A. Wheeler, Li Ding, Jared T. Simpson, Brian D. O’Connor, Sergei Yakneen, Kyle Ellrott, Naoki Miyoshi, Adam P. Butler, Romina Royo, Solomon I. Shorser, Miguel Vazquez, Tobias Rausch, Grace Tiao, Sebastian M. Waszak, Bernardo Rodriguez-Martin, Suyash Shringarpure, Dai Ying Wu, German M. Demidov, Olivier Delaneau, Andy Lynch
Nature 2020 vol. 578 pp. 82-93
Reduced plasma magnesium levels in type-1 diabetes associate with prothrombotic changes in fibrin clotting and fibrinolysis Fladia A. Phoenix, Samantha J. Pitt, Ramzi A. Ajjan, Alan J. Stewart
Thrombosis and Haemostasis 2020 vol. 120 pp. 243-252
The X files Vladan P. Bajic, Mugbubah Essak, Lada Zivkovic, Alan J. Stewart, Sonja Zafirovic, Vladimir Bajic, Takashi Gojobori, Esma Isenovic, Biljana Spremo-Potparevic
Frontiers in Genetics 2020 vol. 10
Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication Antony N. Antoniou, Izabela Lenart, Janos Kriston-Vizi, Takao Iwawaki, Mark Turmaine, Kirsty McHugh, Sadfer Ali, Neil Blake, Paul Bowness, Mona Bajaj-Elliott, Keith Gould, Darren Nesbeth, Simon John Powis
Annals of the Rheumatic Diseases 2019 vol. 78 pp. 74–82
A family of Type VI secretion system effector proteins that form ion-selective pores Giuseppina Mariano, Katharina Trunk, David J. Williams, Laura Monlezun, Henrik Strah, Samantha J. Pitt, Sarah J. Coulthurst
Nature Communications 2019 vol. 10
A metalloproteomic analysis of interactions between plasma proteins and zinc James P. C. Coverdale, James P. Barnett, Adamu Adamu, Ellie Griffiths, Alan J. Stewart, Claudia A. Blindauer
Metallomics 2019 vol. 11 pp. 1805-1819
A novel mutation in SPART gene causes a severe neurodevelopmental delay due to mitochondrial dysfunction with complex I impairments and altered pyruvate metabolism Chiara Diquigiovanni, Christian Bergamini, Irene Liparulo, Francesca Bianco, Luca Masin, Vito Baldassarro, Nicola Rizzardi, Antonia Tranchina, Francesco Bruscherini, Anita Wischmeijer, Tommaso Pippucci, Emanuela Scarano, Duccio Cordelli, Romana Fata, Marco Seri, Silvia Paracchini, Elena Bonora
FASEB Journal 2019 vol. 33 pp. 11284-11302
A self-management programme to reduce falls and improve safe mobility in people with secondary progressive MS Hilary Gunn, Jackie Andrade, Lorna Paul, Linda Miller, Siobhan Creanor, Kara Stevens, Colin Green, Paul Ewings, Andrew Barton, Margie Berrow, Jane Vickery, Ben Marshall, John Peter Zajicek, Jennifer Freeman
Health Technology Assessment 2019 vol. 23 pp. 1-166
Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets Bolin Wang, Hassane El Mkami, Samantha J. Pitt, Jason Schnell, Terry K Smith, Jonathan Lippiat, Bela Ernest Bode, Christos Pliotas
Nature Communications 2019 vol. 10
Assessment of a home-based standing frame programme in people with progressive multiple sclerosis (SUMS) Jennifer A Freeman, Wendy Hendrie, Louise Jarrett, Annie Hawton, Andrew Barton, Rachel Dennett, Benjamin Jones, John Peter Zajicek, Siobhan Creanor
Lancet Neurology 2019 vol. 18 pp. 736-747
Automated analysis of lymphocytic infiltration, tumor budding, and their spatial relationship improves prognostic accuracy in colorectal cancer Kate Lillard, Hideki Ueno, David James Harrison, Peter David Caie
Cancer Immunology Research 2019 vol. 7 pp. 609-620
Automated tumour budding quantification by machine learning augments TNM staging in muscle-invasive bladder cancer prognosis Nicolas Brieu, David James Harrison, Günter Schmidt, Peter David Caie
Scientific Reports 2019 vol. 9
Changes in plasma free fatty acids associated with type-2 diabetes Claudia A. Blindauer, Alan J. Stewart
Nutrients 2019 vol. 11
Coagulatory defects in type-1 and type-2 diabetes Alan J. Stewart
International Journal of Molecular Sciences 2019 vol. 20
Crosstalk between zinc and fatty acids in plasma James P C Coverdale, Siavash Khazaipoul, Swati Arya, Alan J. Stewart, Claudia A Blindauer
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 2019 vol. 1864 pp. 532-542

Athena Swan

Our division is committed to creating an inspiring and inclusive research environment in which all scientists can flourish.