CELLULAR MEDICINE RESEARCH DIVISION

Research at the University of St Andrews School of Medicine

Our strategy

The division of cellular medicine (CMED) combines basic and clinical research with the goal of understanding the cellular and molecular basis of disease. Our interdisciplinary research uses cutting edge technology to address fundamental biomedical processes involved in health and disease.

Research advances

£15M new Artificial Intelligence centre for Scotland to innovate and transform healthcare

Scotland is to have its own £15.8m artificial intelligence health research centre, which promises to enable better patient diagnosis, treatment and outcomes.

The Industrial Centre for Artificial Intelligence Research in Digital Diagnostics, to be known as iCAIRD, brings together a pan-Scotland collaboration of 15 partners from across academia, the NHS and industry.

Professor David Harrison, Principal Investigator for the project, based in St Andrews but with visiting professorships in both Glasgow and Edinburgh, said: “I am delighted that iCAIRD has been awarded £10m from Innovate UK. With our pan-Scotland approach, we will build on existing strengths and deploy AI within NHS Scotland to transform diagnostics and healthcare in Scotland to improve outcomes for patients. Further details.

ERISM

F-actin and nuclei expression (left) and ERISM displacement map (right) at 12-day differentiation of podocytes that are in contact with each other.

N2 domain

X-ray crystal structure of the N2 domain of HRG. PDB: 4CCV

Arrested endosomal maturation in bacterial infection

Kiss1-expressing pyramidal neurons (green) and c-Fos (red) in a hippocampal section of a Kiss1-Cre mouse brain

Calcium flux in a living mouse brain section expressing a genetically encoded calcium indicator. Stimulation was performed using a pulse of hyperkalemic solution. Experiment performed by Dr Tello.

Recent publications

20 (of 161 /dk/atira/pure/researchoutput/status/published available) for Cellular Medicine Division (source: University of St Andrews PURE)
Please click title of any item for full details

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Jeremiah A. Wala, Ofer Shapira, Grace Tiao, Henrik Hornshøj, Julian M. Hess, Randi Istrup Juul, Ziao Lin, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andrés Lanzós, Carl Herrmann, Yosef E. Maruvka, Ciyue Shen, Samirkumar B. Amin, Pratiti Bandopadhayay, Johanna Bertl, Keith A. Boroevich, John Busanovich, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, David Craft, Priyanka Dhingra, Klev Diamanti, Nuno A. Fonseca, Abel Gonzalez-Perez, Qianyun Guo, Mark P. Hamilton, Nicholas J. Haradhvala, Chen Hong, Keren Isaev, Todd A. Johnson, Malene Juul, Andre Kahles, Abdullah Kahraman, Youngwook Kim, Jan Komorowski, Kiran Kumar, Sushant Kumar, Donghoon Lee, Kjong-Van Lehmann, Yilong Li, Eric Minwei Liu, Lucas Lochovsky, Keunchil Park, Oriol Pich, Nicola D. Roberts, Gordon Saksena, Steven Schumacher, Nikos Sidiropoulos, Lina Sieverling, Nasa Sinnott-Armstrong, Chip Stewart, David Tamborero, Jose M. C. Tubio, Husen Umer, Liis Uusküla-Reimand, Claes Wadelius, Lina Wadi, Xiaotong Yao, Cheng-Zhong Zhang, Jing Zhang, James E Haber, Asger Hobolth, Marcin Imielinski, Manolis Kellis, Michael S. Lawrence, Christian von Mering, Hidewaki Nakagawa, Benjamin Raphael, Mark A Rubin, Chris Sander, Lincoln Stein, Joshua M. Stuart, David A. Wheeler, Rory Johnson, Tatsuhiko Tsunoda, Jüri Reimand, Mark Gerstein, Ekta Khurana, Peter J. Campbell, Núria López-Bigas, Joachim Weischenfeldt, Rameen Berouckhim, Iñigo Martincorena, Jakob Skou Pedersen, Gad Getz, Andy Lynch
Nature 2020 vol. 578 pp. 102-111
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing Isidro Cortés-Ciriano, Jake June Koo Lee, Ruibin Xi, Dhawal Jain, Youngsook L. Jung, Lixing Yang, Dmitry Gordenin, Leszek J. Klimczak, Cheng Zhong Zhang, David S. Pellman, Peter J. Park, Kadir C. Akdemir, Eva G. Alvarez, Adrian Baez-Ortega, Rameen Beroukhim, Paul C. Boutros, David Bowtell, Benedikt Brors, Kathleen H. Burns, Peter J. Campbell, Kin Chan, Ken Chen, Isidro Cortés-Ciriano, Ana Dueso-Barroso, Andrew J. Dunford, Paul A. Edwards, Xavier Estivill, Dariush Etemadmoghadam, Lars Feuerbach, J. Lynn Fink, Milana Frenkel-Morgenstern, Dale W. Garsed, Mark Gerstein, Dmitry A. Gordenin, David Haan, James E. Haber, Julian M. Hess, Barbara Hutter, Marcin Imielinski, David T.W. Jones, Young Seok Ju, Marat D. Kazanov, Leszek J. Klimczak, Youngil Koh, Jan O. Korbel, Kiran Kumar, Eunjung Alice Lee, Jake June Koo Lee, Yilong Li, Geoff Macintyre, Andy Lynch
Nature Genetics 2020 vol. 52 pp. 331-341
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer Kadir C. Akdemir, Victoria T. Le, Sahaana Chandran, Yilong Li, Roel G. Verhaak, Rameen Beroukhim, Peter J. Campbell, Lynda Chin, Jesse R. Dixon, Andrew Futreal, Kadir C. Akdemir, Eva G. Alvarez, Adrian Baez-Ortega, Rameen Beroukhim, Paul C. Boutros, David Bowtell, Benedikt Brors, Kathleen H. Burns, Peter J. Campbell, Kin Chan, Ken Chen, Isidro Cortés-Ciriano, Ana Dueso-Barroso, Andrew J. Dunford, Paul A.W. Edwards, Xavier Estivill, Dariush Etemadmoghadam, Lars Feuerbach, J. Lynn Fink, Milana Frenkel-Morgenstern, Dale W. Garsed, Mark Gerstein, Dmitry A. Gordenin, David Haan, James E. Haber, Julian M. Hess, Barbara Hutter, Marcin Imielinski, David T.W. Jones, Young Seok Ju, Marat D. Kazanov, Leszek J. Klimczak, Youngil Koh, Jan O. Korbel, Kiran Kumar, Eunjung Alice Lee, Jake June Koo Lee, Yilong Li, Geoff Macintyre, Andy Lynch
Nature Genetics 2020 vol. 52 pp. 294-305
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations Yiqun Zhang, Fengju Chen, Nuno A. Fonseca, Yao He, Masashi Fujita, Hidewaki Nakagawa, Zemin Zhang, Chad J. Creighton, Alvis Brazma, Samirkumar B. Amin, Philip Awadalla, Peter J. Bailey, Alvis Brazma, Angela N. Brooks, Claudia Calabrese, Aurélien Chateigner, Isidro Cortés-Ciriano, Brian Craft, David Craft, Natalie R. Davidson, Deniz Demircioğlu, Serap Erkek, Nuno A. Fonseca, Milana Frenkel-Morgenstern, Mary J. Goldman, Liliana Greger, Jonathan Göke, Yao He, Katherine A. Hoadley, Yong Hou, Matthew R. Huska, Andre Kahles, Ekta Khurana, Helena Kilpinen, Jan O. Korbel, Fabien C. Lamaze, Kjong Van Lehmann, Chang Li, Siliang Li, Xiaobo Li, Xinyue Li, Dongbing Liu, Fenglin Liu, Xingmin Liu, Maximillian G. Marin, Julia Markowski, Matthew Meyerson, Tannistha Nandi, Morten Muhlig Nielsen, Andy Lynch
Nature Communications 2020 vol. 11
Human handedness: a meta-analysis Marietta Papadatou-Pastou, Eleni Ntolka, Judith Schmitz, Maryanne Martin, Marcus R. Munafò, Sebastian Ocklenburg, Silvia Paracchini
Psychological Bulletin 2020 vol. 146 pp. 481–524
Ovarian hormones induce de novo DNA methyltransferase expression in the Siberian hamster suprachiasmatic nucleus Chris S. Coyle, Federico Caso, Elisabetta Tolla, Perry Barrett, Kenneth G. Onishi, Javier Ananda Tello, Tyler John Stevenson
Journal of Neuroendocrinology 2020 vol. 32
Pan-cancer analysis of whole genomes Peter J. Campbell, Gad Getz, Jan O. Korbel, Joshua M. Stuart, Jennifer L. Jennings, Lincoln D. Stein, Marc D. Perry, Hardeep K. Nahal-Bose, B. F.Francis Ouellette, Constance H. Li, Esther Rheinbay, G. Petur Nielsen, Dennis C. Sgroi, Chin Lee Wu, William C. Faquin, Vikram Deshpande, Paul C. Boutros, Alexander J. Lazar, Katherine A. Hoadley, David N. Louis, L. Jonathan Dursi, Christina K. Yung, Matthew H. Bailey, Gordon Saksena, Keiran M. Raine, Ivo Buchhalter, Kortine Kleinheinz, Matthias Schlesner, Junjun Zhang, Wenyi Wang, David A. Wheeler, Li Ding, Jared T. Simpson, Brian D. O’Connor, Sergei Yakneen, Kyle Ellrott, Naoki Miyoshi, Adam P. Butler, Romina Royo, Solomon I. Shorser, Miguel Vazquez, Tobias Rausch, Grace Tiao, Sebastian M. Waszak, Bernardo Rodriguez-Martin, Suyash Shringarpure, Dai Ying Wu, German M. Demidov, Olivier Delaneau, Andy Lynch
Nature 2020 vol. 578 pp. 82-93
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition Bernardo Rodriguez-Martin, Eva G. Alvarez, Adrian Baez-Ortega, Jorge Zamora, Fran Supek, Jonas Demeulemeester, Martin Santamarina, Young Seok Ju, Javier Temes, Daniel Garcia-Souto, Harald Detering, Yilong Li, Jorge Rodriguez-Castro, Ana Dueso-Barroso, Alicia L. Bruzos, Stefan C. Dentro, Miguel G. Blanco, Gianmarco Contino, Daniel Ardeljan, Marta Tojo, Nicola D. Roberts, Sonia Zumalave, Paul A.W. Edwards, Joachim Weischenfeldt, Montserrat Puiggròs, Zechen Chong, Ken Chen, Eunjung Alice Lee, Jeremiah A. Wala, Keiran Raine, Adam Butler, Sebastian M. Waszak, Fabio C.P. Navarro, Steven E. Schumacher, Jean Monlong, Francesco Maura, Niccolo Bolli, Guillaume Bourque, Mark Gerstein, Peter J. Park, David C. Wedge, Rameen Beroukhim, David Torrents, Jan O. Korbel, Inigo Martincorena, Rebecca C. Fitzgerald, Peter Van Loo, Haig H. Kazazian, Kathleen H. Burns, Peter J. Campbell, Jose M.C. Tubio, Andy Lynch
Nature Genetics 2020 vol. 52 pp. 306-319
Patterns of somatic structural variation in human cancer genomes Yilong Li, Nicola D. Roberts, Jeremiah A. Wala, Ofer Shapira, Steven E. Schumacher, Kiran Kumar, Ekta Khurana, Sebastian M. Waszak, Jan O. Korbel, James E. Haber, Marcin Imielinski, Joachim Weischenfeldt, Rameen Beroukhim, Peter J. Campbell, Kadir C. Akdemir, Eva G. Alvarez, Adrian Baez-Ortega, Paul C. Boutros, David Bowtell, Benedikt Brors, Kathleen H. Burns, Kin Chan, Ken Chen, Isidro Cortés-Ciriano, Ana Dueso-Barroso, Andrew J. Dunford, Paul A. Edwards, Xavier Estivill, Dariush Etemadmoghadam, Lars Feuerbach, J. Lynn Fink, Milana Frenkel-Morgenstern, Dale W. Garsed, Mark Gerstein, Dmitry A. Gordenin, David Haan, James E. Haber, Julian M. Hess, Barbara Hutter, Marcin Imielinski, David T.W. Jones, Young Seok Ju, Marat D. Kazanov, Leszek J. Klimczak, Youngil Koh, Jan O. Korbel, Kiran Kumar, Eunjung Alice Lee, Jake June Koo Lee, Yilong Li, Andy Lynch
Nature 2020 vol. 578 pp. 112-121
Prostaglandin E2 stimulates the epithelial sodium channel (ENaC) in cultured mouse cortical collecting duct cells in an autocrine manner Morag Mansley, Christian Niklas, Regina Nacken, Kathrin Mandery, Hartmut Glaeser, Martin F. Fromm, Christoph Korbmacher, Marko Bertog
The Journal of general physiology 2020 vol. 152
Reduced plasma magnesium levels in type-1 diabetes associate with prothrombotic changes in fibrin clotting and fibrinolysis Amelie Isabelle Sylvie Sobczak, Fladia A. Phoenix, Samantha J. Pitt, Ramzi A. Ajjan, Alan J. Stewart
Thrombosis and Haemostasis 2020 vol. 120 pp. 243-252
Spatial immune profiling of the colorectal tumor microenvironment predicts good outcome in stage II patients Ines Nearchou, Bethany M. Gwyther, Elena C. T. Georgiakakis, Kate Lillard, Yoshiki Kajiwara, Hideki Ueno, David James Harrison, Peter David Caie
npj Digital Medicine 2020 vol. 3
The X files Vladan P. Bajic, Mugbubah Essak, Lada Zivkovic, Alan J. Stewart, Sonja Zafirovic, Vladimir Bajic, Takashi Gojobori, Esma Isenovic, Biljana Spremo-Potparevic
Frontiers in Genetics 2020 vol. 10
The efficacy of sunitinib treatment of renal cancer is associated with the protein PHAX in vitro Rafia S. Al-Lamki, Nicholas J. Hudson, John R. Bradley, Anne Y. Warren, Tim Eisen, Sarah J. Welsh, Antony C. P. Riddick, Fiach C. O'Mahony, Arran Turnbull, Thomas Powles, Antonio Reverter, David James Harrison, Grant D. Stewart
Biology 2020 vol. 9
The mechanobiology of kidney podocytes in health and disease Paul Andrew Reynolds
Clinical Science 2020 vol. 134 pp. 1245–1253
Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication Antony N. Antoniou, Izabela Lenart, Janos Kriston-Vizi, Takao Iwawaki, Mark Turmaine, Kirsty McHugh, Sadfer Ali, Neil Blake, Paul Bowness, Mona Bajaj-Elliott, Keith Gould, Darren Nesbeth, Simon John Powis
Annals of the Rheumatic Diseases 2019 vol. 78 pp. 74–82
A family of Type VI secretion system effector proteins that form ion-selective pores Giuseppina Mariano, Katharina Trunk, David J. Williams, Laura Monlezun, Henrik Strah, Samantha J. Pitt, Sarah J. Coulthurst
Nature Communications 2019 vol. 10
A metalloproteomic analysis of interactions between plasma proteins and zinc James P. C. Coverdale, James P. Barnett, Adamu Adamu, Ellie Griffiths, Alan J. Stewart, Claudia A. Blindauer
Metallomics 2019 vol. 11 pp. 1805-1819

Athena Swan

Our division is committed to creating an inspiring and inclusive research environment in which all scientists can flourish.