Research: P. knowlesi genomics

  • Genomics and artemisWe have developed a method to extract P. knowlesi
    DNA from frozen clinical blood samples to generate P. knowlesi genome sequences.
  • Extracted DNA was of sufficient quality to produce high coverage genome sequences from six patient isolates.
  • Using a combination of whole genome sequencing and targeted deep sequencing we will produce comprehensive P. knowlesi DNA sequence from at least 100 clinically well characterised patients in our sample archive.
  • The sequences provide a rich resource for comparative genomics, P. knowlesi diversity and identifying virulence loci genome wide.
  • Preliminary data from six isolates has identified variationĀ on loci associated with drug resistance in other Plasmodium species.