Research at the University of St Andrews School of Medicine


Infection group recent publications

Recent publications listed in research@st-andrews

Mohamed, N, Timofeyeva, Y, Jamrozy, D, Rojas, E, Hao, L, Silmon de Monerri, NC, Hawkins, J, Singh, G, Cai, B, Liberator, P, Sebastian, S, Donald, RGK, Scully, IL, Jones, CH, Creech, CB, Thomsen, I, Parkhill, J, Peacock, SJ, Jansen, KU, Holden, MTG & Anderson, AS 2019, 'Molecular epidemiology and expression of capsular polysaccharides in Staphylococcus aureus clinical isolates in the United States' PLoS ONE, vol. 14, no. 1, e0208356. DOI: 10.1371/journal.pone.0208356
Murphy, ME, Wills, GH, Murthy, S, Louw, C, Bateson, ALC, Hunt, RD, McHugh, TD, Nunn, AJ, Meredith, SK, Mendel, CM, Spigelman, M, Crook, AM, Gillespie, SH & REMoxTB Consortium 2018, 'Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study' BMC Medicine, vol. 16, 189. DOI: 10.1186/s12916-018-1169-5
Zapotoczna, M, Riboldi, GP, Moustafa, AM, Dickson, E, Narechania, A, Morrissey, JA, Planet, PJ, Holden, MTG, Waldron, KJ & Geoghegan, JA 2018, 'Mobile-genetic-element-encoded hypertolerance to copper protects Staphylococcus aureus from killing by host phagocytes' mBio, vol. 9, no. 5, e00550-18. DOI: 10.1128/mBio.00550-18
Ahmed, MIM, Ntinginya, NE, Kibiki, G, Mtafya, BA, Semvua, H, Mpagama, S, Mtabho, C, Saathoff, E, Held, K, Loose, R, Kroidl, I, Chachage, M, Both, UV, Haule, A, Mekota, A-M, Boeree, MJ, Gillespie, SH, Hoelscher, M, Heinrich, N, Geldmacher, C & Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA) 2018, 'Phenotypic changes on Mycobacterium tuberculosis-specific CD4 T cells as surrogate markers for tuberculosis treatment efficacy' Frontiers in Immunology, vol. 9, 2247. DOI: 10.3389/fimmu.2018.02247
Restrepo, MI, Babu, BL, Reyes, LF, Chalmers, JD, Soni, NJ, Sibila, O, Faverio, P, Cilloniz, C, Rodriguez-Cintron, W, Aliberti, S & GLIMP 2018, 'Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients' European Respiratory Journal, vol. 52, no. 2, 1701190. DOI: 10.1183/13993003.01190-2017
Harkins, CP, McAleer, MA, Bennett, D, McHugh, M, Fleury, OM, Pettigrew, KA, Oravcová, K, Parkhill, J, Proby, CM, Dawe, RS, Geoghegan, JA, Irvine, AD & Holden, MTG 2018, 'The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from Atopic Dermatitis patients' British Journal of Dermatology, vol. Early View. DOI: 10.1111/bjd.16722
Richardson, EJ, Bacigalupe, R, Harrison, EM, Weinert, LA, Lycett, S, Vrieling, M, Robb, K, Hoskisson, PA, Holden, MTG, Feil, EJ, Paterson, GK, Tong, SYC, Shittu, A, van Wamel, W, Aanensen, DM, Parkhill, J, Peacock, SJ, Corander, J, Holmes, M & Fitzgerald, JR 2018, 'Gene exchange drives the ecological success of a multi-host bacterial pathogen' Nature Ecology and Evolution, vol. 2, pp. 1468-1478. DOI: 10.1038/s41559-018-0617-0
Tweed, CD, Crook, AM, Amukoye, EI, Dawson, R, Diacon, AH, Hanekom, M, McHugh, TD, Mendel, CM, Meredith, SK, Murphy, ME, Murthy, SE, Nunn, AJ, Phillips, PPJ, Singh, KP, Spigelman, M, Wills, GH & Gillespie, SH 2018, 'Toxicity associated with tuberculosis chemotherapy in the REMoxTB study' BMC Infectious Diseases, vol. 18, 317. DOI: 10.1186/s12879-018-3230-6
van Hal, SJ, Steinig, EJ, Andersson, P, Holden, MTG, Harris, SR, Nimmo, GR, Williamson, DA, Heffernan, H, Ritchie, SR, Kearns, AM, Ellington, MJ, Dickson, E, de Lencastre, H, Coombs, GW, Bentley, SD, Parkhill, J, Holt, DC, Giffard, PM & Tong, SYC 2018, 'Global scale dissemination of ST93: a divergent Staphylococcus aureus epidemic lineage that has recently emerged from remote Northern Australia' Frontiers in Microbiology, vol. 9, 1453. DOI: 10.3389/fmicb.2018.01453
Bossé, JT, Li, Y, Fernandez Crespo, R, Lacouture, S, Gottschalk, M, Sárközi, R, Fodor, L, Casas Amoribieta, M, Angen, Ø, Nedbalcova, K, Holden, MTG, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & BRaDP1T Consortium 2018, 'Comparative sequence analysis of the capsular polysaccharide loci of Actinobacillus pleuropneumoniae serovars 1-18, and development of two multiplex PCRs for comprehensive capsule typing' Veterinary Microbiology, vol. 220, pp. 83-89. DOI: 10.1016/j.vetmic.2018.05.011
Bergin, SM, Periaswamy, B, Barkham, T, Chua, HC, Mok, YM, Fung, DSS, Su, AHC, Lee, YL, Chua, MLI, Ng, PY, Soon, WJW, Chu, CW, Tan, SL, Meehan, M, Ang, BSP, Leo, YS, Holden, MTG, De, P, Hsu, LY, Chen, SL, de Sessions, PF & Marimuthu, K 2018, 'An outbreak of Streptococcus pyogenes in a mental health facility: advantage of well-timed whole-genome sequencing over emm typing' Infection Control and Hospital Epidemiology, vol. 39, no. 7, pp. 852-860. DOI: 10.1017/ice.2018.101
Svensson, EM, Svensson, RJ, Te Brake, LHM, Boeree, MJ, Heinrich, N, Konsten, S, Churchyard, G, Dawson, R, Diacon, AH, Kibiki, GS, Minja, LT, Ntingiya, NE, Sanne, I, Gillespie, SH, Hoelscher, M, Phillips, PPJ, Simonsson, USH & Aarnoutse, R 2018, 'The potential for treatment shortening with higher rifampicin doses: relating drug exposure to treatment response in patients with pulmonary tuberculosis' Clinical Infectious Diseases, vol. 67, no. 1, pp. 34-41. DOI: 10.1093/cid/ciy026
Murthy, SE, Chatterjee, F, Crook, A, Dawson, R, Mendel, C, Murphy, ME, Murray, SR, Nunn, AJ, Phillips, PPJ, Singh, KP, McHugh, TD, Gillespie, SH & REMoxTB Consortium 2018, 'Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis' BMC Medicine, vol. 16, 73. DOI: 10.1186/s12916-018-1053-3
Svensson, RJ, Svensson, EM, Aarnoutse, RE, Diacon, AH, Dawson, R, Gillespie, SH, Moodley, M, Boeree, MJ & Simonsson, USH 2018, 'Greater early bactericidal activity at higher rifampicin doses revealed by modeling and clinical trial simulations' Journal of Infectious Diseases, vol. In press. DOI: 10.1093/infdis/jiy242
Rachow, A, Saathoff, E, Mtafya, B, Mapamba, D, Mangu, C, Rojas-Ponce, G, Ntinginya, NE, Boeree, M, Heinrich, N, Gillespie, SH, Hoelscher, M & PanACEA Consortium 2018, 'The impact of repeated NALC/NaOH- decontamination on the performance of Xpert MTB/RIF assay' Tuberculosis, vol. In press. DOI: 10.1016/
Hao, L, Holden, MTG, Wang, X, Andrew, L, Wellnitz, S, Hu, F, Whaley, M, Sammons, S, Knipe, K, Frace, M, McNamara, LA, Liberator, P & Anderson, AS 2018, 'Distinct evolutionary patterns of Neisseria meningitidis serogroup B disease outbreaks at two universities in the USA' Microbial Genomics, vol. 4, no. 4, e000155. DOI: 10.1099/mgen.0.000155
Fregonese, F, Ahuja, SD, Akkerman, OW, Arakaki-Sanchez, D, Ayakaka, I, Baghaei, P, Bang, D, Bastos, M, Benedetti, A, Bonnet, M, Cattamanchi, A, Cegielski, P, Chien, J-Y, Cox, H, Dedicoat, M, Erkens, C, Escalante, P, Falzon, D, Garcia-Prats, AJ, Gegia, M, Gillespie, SH, Glynn, JR, Goldberg, S, Griffith, D, Jacobson, KR, Johnston, JC, Jones-López, EC, Khan, A, Koh, W-J, Kritski, A, Lan, ZY, Lee, JH, Li, PZ, Maciel, EL, Galliez, RM, Merle, CSC, Munang, M, Narendran, G, Nguyen, VN, Nunn, A, Ohkado, A, Park, JS, Phillips, PPJ, Ponnuraja, C, Reves, R, Romanowski, K, Seung, K, Schaaf, HS, Skrahina, A, Soolingen, DV, Tabarsi, P, Trajman, A, Trieu, L, Banurekha, VV, Viiklepp, P, Wang, J-Y, Yoshiyama, T & Menzies, D 2018, 'Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis' The Lancet Respiratory Medicine, vol. 6, no. 4, pp. 265-275. DOI: 10.1016/S2213-2600(18)30078-X
Bossé, JT, Li, Y, Sárközi, R, Fodor, L, Lacouture, S, Gottschalk, M, Amoribieta, MC, Angen, Ø, Nedbalcova, K, Holden, MTG, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & BRaDP1T Consortium 2018, 'Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis' Veterinary Microbiology, vol. 217, pp. 1-6. DOI: 10.1016/j.vetmic.2018.02.019
Tweed, CD, Wills, GH, Crook, AM, Dawson, R, Diacon, AH, Louw, CE, McHugh, TD, Mendel, C, Meredith, S, Mohapi, L, Murphy, ME, Murray, S, Murthy, S, Nunn, AJ, Phillips, PPJ, Singh, K, Spigelman, M & Gillespie, SH 2018, 'Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study' BMC Medicine, vol. 16, 46. DOI: 10.1186/s12916-018-1033-7
Baron, VO, Chen, M, Clark, SO, Williams, A, Dholakia, K & Gillespie, SH 2018, Detecting phenotypically resistant Mycobacterium tuberculosis using wavelength modulated Raman spectroscopy. in S Gillespie (ed.), Antibiotic Resistance Protocols. Methods in Molecular Biology, vol. 1736, Humana Press/Springer, New York, NY, pp. 41-50. DOI: 10.1007/978-1-4939-7638-6_4
Hammond, RJH, Baron, VO, Lipworth, S & Gillespie, SH 2018, Enhanced methodologies for detecting phenotypic resistance in mycobacteria. in S Gillespie (ed.), Antibiotic Resistance Protocols. Methods in Molecular Biology, vol. 1736, Humana Press/Springer, New York, NY, pp. 85-94. DOI: 10.1007/978-1-4939-7638-6_8
Xaio, H & Gillespie, SH 2018, Using RT qPCR for quantifying Mycobacteria marinum from in vitro and in vivo samples. in S Gillespie (ed.), Antibiotic Resistance Protocols. Methods in Molecular Biology, vol. 1736, Humana Press/Springer, New York, NY, pp. 137-145. DOI: 10.1007/978-1-4939-7638-6_13
Casabona, MG, Buchanan, G, Zoltner, M, Harkins, CP, Holden, MTG & Palmer, T 2017, 'Functional analysis of the EsaB component of the Staphylococcus aureus Type VII secretion system' Microbiology, vol. 163, no. 12, pp. 1851-1863. DOI: 10.1099/mic.0.000580
Casabona, MG, Kneuper, H, Alferes de Lima, D, Harkins, CP, Zoltner, M, Hjerde, E, Holden, MTG & Palmer, T 2017, 'Haem-iron plays a key role in the regulation of the Ess/type VII secretion system of Staphylococcus aureus RN6390' Microbiology, vol. 163, no. 12, pp. 1839-1850. DOI: 10.1099/mic.0.000579
Aarnoutse, RE, Kibiki, GS, Reither, K, Semvua, HH, Haraka, F, Mtabho, CM, Mpagama, SG, van den Boogaard, J, Sumari-de Boer, IM, Magis-Escurra, C, Wattenberg, M, Logger, JGM, te Brake, LHM, Hoelscher, M, Gillespie, SH, Colbers, A, Phillips, PPJ, Plemper van Balen, G, Boeree, MJ & PanACEA Consortium 2017, 'Pharmacokinetics, tolerability, and bacteriological response of rifampin administered at 600, 900, and 1,200 milligrams daily in patients with pulmonary tuberculosis' Antimicrobial Agents and Chemotherapy, vol. 61, no. 11, e01054-17. DOI: 10.1128/AAC.01054-17
Murphy, ME, Phillips, PPJ, Mendel, CM, Bongard, E, Bateson, ALC, Hunt, R, Murthy, S, Singh, KP, Brown, M, Crook, AM, Nunn, AJ, Meredith, SK, Lipman, M, McHugh, TD, Gillespie, SH & REMoxTB Consortium 2017, 'Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis' BMC Medicine, vol. 15, 192. DOI: 10.1186/s12916-017-0947-9
Harkins, CP, Pettigrew, KA, Oravcova, K, Gardner, J, Hearn, R, Rice, D, Mather, AE, Parkhill, J, Brown, SJ, Proby, CM & Holden, MT 2017, 'The genetic diversity of Staphylococcus aureus colonisation in atopic eczema disease flare' Journal of Investigative Dermatology, vol. 137, no. 10, pp. S258-S258.
Walsh, SLF, Maher, TM, Kolb, M, Poletti, V, Nusser, R, Richeldi, L, Vancheri, C, Wilsher, ML, Antoniou, KM, Behr, J, Bendstrup, E, Brown, K, Calandriello, L, Corte, TJ, Cottin, V, Crestani, B, Flaherty, K, Glaspole, I, Grutters, J, Inoue, Y, Kokosi, M, Kondoh, Y, Kouranos, V, Kreuter, M, Johannson, K, Judge, E, Ley, B, Margaritopoulos, G, Martinez, FJ, Molina-Molina, M, Morais, A, Nunes, H, Raghu, G, Ryerson, CJ, Selman, M, Spagnolo, P, Taniguchi, H, Tomassetti, S, Valeyre, D, Wijsenbeek, M, Wuyts, W, Hansell, D, Wells, A, IPF Project Consortium & Dhasmana, DJ 2017, 'Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study' European Respiratory Journal, vol. 50, no. 2, 1700936. DOI: 10.1183/13993003.00936-2017
Sarovich, DS, Chapple, SNJ, Price, EP, Mayo, M, Holden, MTG, Peacock, SJ & Currie, BJ 2017, 'Whole-genome sequencing to investigate a non-clonal melioidosis cluster on a remote Australian island' Microbial Genomics, vol. 3, no. 8, e000117. DOI: 10.1099/mgen.0.000117
Björnsdóttir, S, Harris, SR, Svansson, V, Gunnarsson, E, Sigurðardóttir, ÓG, Gammeljord, K, Steward, KF, Newton, JR, Robinson, C, Charbonneau, ARL, Parkhill, J, Holden, MTG & Waller, AS 2017, 'Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases' mBio, vol. 8, no. 4, e00826-17. DOI: 10.1128/mBio.00826-17
Hsu, L-Y, Holden, MTG, Koh, TH, Pettigrew, KA, Cao, D, Hon, PY, Sergio, DM, Pena, E & Ogden, BE 2017, 'ST3268: a geographically widespread primate MRSA clone' Journal of Antimicrobial Chemotherapy, vol. 72, no. 8, pp. 2401-2403. DOI: 10.1093/jac/dkx120
Harkins, CP, Pichon, B, Doumith, M, Parkhill, J, Westh, H, Tomasz, A, de Lencastre, H, Bentley, SD, Kearns, AM & Holden, MTG 2017, 'Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice' Genome Biology, vol. 18, 130. DOI: 10.1186/s13059-017-1252-9
Donker, T, Reuter, S, Scriberras, J, Reynolds, R, Brown, NM, Török, ME, James, R, Network, EOEMR, Aanensen, DM, Bentley, SD, Holden, MTG, Parkhill, J, Spratt, BG, Peacock, SJ, Feil, EJ & Grundmann, H 2017, 'Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns' Microbial Genomics, vol. 3, no. 7, e000113. DOI: 10.1099/mgen.0.000113
Kalimuddin, S, Chen, SL, Lim, CTK, Koh, TH, Tan, TY, Kam, M, Wong, CW, Mehershahi, KS, Chau, ML, Ng, LC, Tang, WY, Badaruddin, H, Teo, J, Apisarnthanarak, A, Suwantarat, N, Ip, M, Holden, MTG, Hsu, LY, Barkham, T & Singapore Group B Streptococcus Consortium 2017, '2015 epidemic of severe Streptococcus agalactiae sequence type 283 infections in Singapore associated with the consumption of raw freshwater fish: a detailed analysis of clinical, epidemiological, and bacterial sequencing data' Clinical Infectious Diseases, vol. 64, no. suppl_2, pp. S145-S152. DOI: 10.1093/cid/cix021
Chow, A, Lim, VW, Khan, A, Pettigrew, K, Lye, DCB, Kanagasabai, K, Phua, K, Krishnan, P, Ang, B, Marimuthu, K, Hon, P-Y, Koh, J, Leong, I, Parkhill, J, Hsu, L-Y & Holden, MTG 2017, 'MRSA transmission dynamics among interconnected acute, intermediate-term, and long-term healthcare facilities in Singapore' Clinical Infectious Diseases, vol. 64, no. suppl_2, pp. S76-S81. DOI: 10.1093/cid/cix072
Kayria, M, Chris, O, Dhasmana, DJ, Nilesh, M, Hodson, ME, Khin, G, Diana, B & Simmonds, NJ 2017, 'Burkholderia cepacia complex and limited cutaneous vasculitis in patients with cystic fibrosis: a case series' JRSM Open, vol. 8, no. 4, pp. 1-4. DOI: 10.1177/2054270417692732
Bossé, JT, Li, Y, Rogers, J, Crespo, RF, Li, Y, Chaudhuri, RR, Holden, MTG, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & BRaDP1T Consortium 2017, 'Whole genome sequencing for surveillance of antimicrobial resistance in Actinobacillus pleuropneumoniae' Frontiers in Microbiology, vol. 8, 311. DOI: 10.3389/fmicb.2017.00311
Muliaditan, M, Davies, GR, Simonsson, USH, Gillespie, SH & Pasqua, OD 2017, 'The implications of model–informed drug discovery and development for tuberculosis' Drug Discovery Today, vol. 22, no. 3, pp. 481-486. DOI: 10.1016/j.drudis.2016.09.004
Chewapreecha, C, Holden, MTG, Vehkala, M, Välimäki, N, Yang, Z, Harris, SR, Mather, AE, Tuanyok, A, De Smet, B, Le Hello, S, Bizet, C, Mayo, M, Wuthiekanun, V, Limmathurotsakul, D, Phetsouvanh, R, Spratt, BG, Corander, J, Keim, P, Dougan, G, Dance, DAB, Currie, BJ, Parkhill, J & Peacock, SJ 2017, 'Global and regional dissemination and evolution of Burkholderia pseudomallei' Nature Microbiology, vol. 2, 16263. DOI: 10.1038/nmicrobiol.2016.263
Ellington, MJ, Ekelund, O, Aarestrup, FM, Canton, R, Doumith, M, Giske, C, Grundman, H, Hasman, H, Holden, MTG, Hopkins, KL, Iredell, J, Kahlmeter, G, Köser, CU, MacGowan, A, Mevius, D, Mulvey, M, Naas, T, Peto, T, Rolain, J-M, Samuelsen, Ø & Woodford, N 2017, 'The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee' Clinical Microbiology and Infection, vol. 23, no. 1, pp. 2-22. DOI: 10.1016/j.cmi.2016.11.012
Boeree, MJ, Heinrich, N, Aarnoutse, R, Diacon, AH, Dawson, R, Rehal, S, Kibiki, GS, Churchyard, G, Sanne, I, Ntinginya, NE, Minja, LT, Hunt, RD, Charalambous, S, Hanekom, M, Semvua, HH, Mpagama, SG, Manyama, C, Mtafya, B, Reither, K, Wallis, RS, Venter, A, Narunsky, K, Mekota, A, Henne, S, Colbers, A, Plemper van Balen, G, Gillespie, SH, Phillips, PPJ & Hoelscher, M 2017, 'High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial' Lancet Infectious Diseases, vol. 17, no. 1, pp. 39-49. DOI: 10.1016/S1473-3099(16)30274-2, 10.1016/S1473-3099(16)30274-2
Gillespie, SH, Sabiiti, W & Oravcova, K 2017, Mycobacterial load assay. in KA Bishop-Lilly (ed.), Diagnostic Bacteriology: Methods and Protocols. Methods in Molecular Biology, vol. 1616, Humana Press/Springer, New York, NY, pp. 89-105. DOI: 10.1007/978-1-4939-7037-7_5
Afshar, B, Turner, CE, Lamagni, T, Smith, K, Al-Shahib, A, Underwood, A, Holden, MTG, Efstratiou, A & Sriskandan, S 2017, 'Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus' Virulence, vol. 8, no. 7, pp. 1390-1400. DOI: 10.1080/21505594.2017.1325070
Aliberti, S, Reyes, LF, Faverio, P, Sotgiu, G, Dore, S, Rodriguez, AH, Soni, NJ, Restrepo, MI, GLIMP investigators & Dhasmana, DJ 2016, 'Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study' Lancet Infectious Diseases, vol. 16, no. 12, pp. 1364-1376. DOI: 10.1016/S1473-3099(16)30267-5
Argimón, S, Abudahab, K, Goater, RJE, Fedosejev, A, Bhai, J, Glasner, C, Feil, EJ, Holden, MTG, Yeats, CA, Grundmann, H, Spratt, BG & Aanensen, DM 2016, 'Microreact: visualizing and sharing data for genomic epidemiology and phylogeography' Microbial Genomics, vol. 2, no. 11. DOI: 10.1099/mgen.0.000093
Sabiiti, W, Mtafya, B, Kuchaka, D, Azam, K, Viegas, S, Mdolo, A, Farmer, E, Khonga, M, Evangelopoulos, D, Honeyborne, I, Rachow, A, Heinrich, N, Ntinginya, NE, Bhatt, N, Davies, GR, Jani, IV, McHugh, TD, Kibiki, G, Hoelscher, M, Gillespie, SH & PANBIOME (Pan-African Biomarker Expansion Programme) consortium 2016, 'Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings' International Journal of Tuberculosis and Lung Disease, vol. 20, no. 8, pp. 1004-1009. DOI: 10.5588/ijtld.15.0951
Chapple, SNJ, Sarovich, DS, Holden, MTG, Peacock, SJ, Buller, N, Golledge, C, Currie, BJ, Mayo, M & Price, EP 2016, 'Whole-genome sequencing of a quarter-century melioidosis outbreak in temperate Australia uncovers a region of low-prevalence endemicity' Microbial Genomics, vol. 2, no. 7. DOI: 10.1099/mgen.0.000067
Lipworth, S, Hammond, RJH, Baron, VO, Hu, Y, Coates, A & Gillespie, SH 2016, 'Defining dormancy in mycobacterial disease' Tuberculosis, vol. 99, pp. 131-142. DOI: 10.1016/
Bosse, JT, Li, Y, Crespo, RF, Chaudhuri, RR, Rogers, J, Holden, MTG, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & BRaDP1T Consortium 2016, 'ICEApl1, an integrative conjugative element related to ICEHin1056, identified in the pig pathogen Actinobacillus pleuropneumoniae' Frontiers in Microbiology, vol. 7, 810. DOI: 10.3389/fmicb.2016.00810
Boeree, MJ, Gillespie, SH, Hoelscher, M & PanACEA core team 2016, 'Therapy for Tuberculous Meningitis' New England Journal of Medicine, vol. 374, no. 22, pp. 2187-8. DOI: 10.1056/NEJMc1602291#SA2
Jamrozy, DM, Harris, SR, Mohamed, N, Peacock, SJ, Tan, CY, Parkhill, J, Anderson, AS & Holden, MTG 2016, 'Pan-genomic perspective on the evolution of the Staphylococcus aureus USA300 epidemic' Microbial Genomics, vol. 2, no. 5, pp. 1-14. DOI: 10.1099/mgen.0.000058
Dhasmana, DJ, Harrison, F, Hartley, T & Szapiro, D 2016, 'Evaluation of the healthcare burden of Idiopathic Pulmonary Fibrosis (IPF) in Fife, Scotland' American Thoracic Society Conference 2016, San Francisco, United States, 13/05/16 - 18/05/16, .
Aanensen, DM, Feil, EJ, Holden, MTG, Dordel, J, Yeats, CA, Fedosejev, A, Goater, R, Castillo-Ramírez, S, Corander, J, Colijn, C, Chlebowicz, MA, Schouls, L, Heck, M, Pluister, G, Ruimy, R, Kahlmeter, G, Åhman, J, Matuschek, E, Friedrich, AW, Parkhill, J, Bentley, SD, Spratt, BG, Grundmann, H & European Staphylococcal Reference Laboratory Working Group 2016, 'Whole-genome sequencing for routine pathogen surveillance in public health: a population snapshot of invasive Staphylococcus aureus in Europe' mBio, vol. 7, no. 3, e00444-16, pp. 1-15. DOI: 10.1128/mBio.00444-16
Honeyborne, I, McHugh, TD, Kuittinen, I, Cichonska, A, Evangelopoulos, D, Ronacher, K, van Helden, PD, Gillespie, SH, Fernandez-Reyes, D, Walzl, G, Rousu, J, Butcher, PD & Waddell, SJ 2016, 'Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy' BMC Medicine, vol. 14, no. 1, pp. 1-13. DOI: 10.1186/s12916-016-0609-3
Phillips, PPJ, Dooley, KE, Gillespie, SH, Heinrich, N, Stout, JE, Nahid, P, Diacon, AH, Aarnoutse, RE, Kibiki, GS, Boeree, MJ & Hoelscher, M 2016, 'A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP)' BMC Medicine, vol. 14, 51, pp. 1-11. DOI: 10.1186/s12916-016-0597-3
Warne, B, Harkins, CP, Harris, SR, Vatsiou, A, Stanley-Wall, N, Parkhill, J, Peacock, SJ, Palmer, T & Holden, MTG 2016, 'The Ess/Type VII secretion system of Staphylococcus aureus shows unexpected genetic diversity' BMC Genomics, vol. 17, no. 1, pp. 222. DOI: 10.1186/s12864-016-2426-7
Reuter, S, Török, EM, Holden, MT, Reynolds, R, Raven, KE, Blane, B, Donker, T, Bentley, SD, Aanensen, DM, Grundmann, H, Feil, EJ, Spratt, BG, Parkhill, J & Peacock, SJ 2016, 'Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland' Genome Research, vol. 26, no. 2, pp. 263-270. DOI: 10.1101/gr.196709.115
Bossé, JT, Chaudhuri, RR, Li, Y, Leanse, LG, Fernandez Crespo, R, Coupland, P, Holden, MTG, Bazzolli, DM, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & BRaDP1T Consortium 2016, 'Complete genome sequence of MIDG2331, a genetically tractable serovar 8 clinical isolate of Actinobacillus pleuropneumoniae' Genome Announcements, vol. 4, no. 1, e01667-15. DOI: 10.1128/genomeA.01667-15
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Harrison, EM, Paterson, GK, Holden, MTG, Morgan, FJE, Larsen, AR, Petersen, A, Leroy, S, De Vliegher, S, Perreten, V, Fox, LK, Lam, TJGM, Sampimon, OC, Zadoks, RN, Peacock, SJ, Parkhill, J & Holmes, MA 2013, 'A Staphylococcus xylosus Isolate with a new mecC Allotype' Antimicrobial Agents and Chemotherapy, vol. 57, no. 3, pp. 1524-1528. DOI: 10.1128/AAC.01882-12
Harris, SR, Cartwright, EJP, Toeroek, ME, Holden, MTG, Brown, NM, Ogilvy-Stuart, AL, Ellington, MJ, Quail, MA, Bentley, SD, Parkhill, J & Peacock, SJ 2013, 'Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study' Lancet Infectious Diseases, vol. 13, no. 2, pp. 130-136. DOI: 10.1016/S1473-3099(12)70268-2
Boonsilp, S, Thaipadungpanit, J, Amornchai, P, Wuthiekanun, V, Bailey, MS, Holden, M, Zhang, C, Jiang, X, Koizumi, N, Taylor, K, Galloway, R, Hoffmaster, AR, Craig, S, Smythe, LD, Hartskeerl, RA, Day, NP, Chantratita, N, Feil, EJ, Aanensen, DM, Spratt, BG & Peacock, SJ 2013, 'A Single Multilocus Sequence Typing (MLST) scheme for seven pathogenic Leptospira Species' PLoS Neglected Tropical Diseases, vol. 7, no. 1, e1954. DOI: 10.1371/journal.pntd.0001954
Friedrich, SO, Rachow, A, Saathoff, E, Singh, K, Mangu, CD, Dawson, R, Phillips, P, Venter, A, Bateson, A, Boehme, CC, Heinrich, N, Hunt, R, Boeree, MJ, Zumla, A, McHugh, TD, Gillespie, SH, Diacon, A & Hoelscher, M 2013, 'Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment' The Lancet Respiratory Medicine, vol. 1, no. 6, pp. 462-470. DOI: 10.1016/S2213-2600(13)70119-X
Juul, S, Nielsen, CJF, Labouriau, R, Roy, A, Tesauro, C, Jensen, PW, Harmsen, C, Kristoffersen, EL, Chiu, YL, Frohlich, R, Fiorani, P, Cox-Singh, J, Tordrup, D, Koch, J, Bienvenu, AL, Desideri, A, Picot, S, Petersen, E, Leong, KW, Ho, YP, Stougaard, M & Knudsen, BR 2012, 'Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing plasmodium parasites based on enzyme activity measurement' ACS Nano, vol. 6, no. 12, pp. 10676-10683. DOI: 10.1021/nn3038594
Willmann, M, Ahmed, A, Siner, A, Wong, IT, Woon, LC, Singh, B, Krishna, S & Cox Singh, J 2012, 'Laboratory markers of disease severity in Plasmodium knowlesi infection: a case control study' Malaria Journal, vol. 11, no. 363, 363. DOI: 10.1186/1475-2875-11-363
Turner, CE, Sommerlad, M, McGregor, K, Davies, FJ, Pichon, B, Chong, DLW, Farzaneh, L, Holden, MTG, Spratt, BG, Efstratiou, A & Sriskandan, S 2012, 'Superantigenic Activity of emm3 Streptococcus pyogenes Is Abrogated by a Conserved, Naturally Occurring smeZ Mutation' PLoS One, vol. 7, no. 10, 46376. DOI: 10.1371/journal.pone.0046376
Ito, T, Hiramatsu, K, Tomasz, A, de Lencastre, H, Perreten, V, Holden, MTG, Coleman, DC, Goering, R, Giffard, PM, Skov, RL, Zhang, K, Westh, H, O'Brien, F, Tenover, FC, Oliveira, DC, Boyle-Vavra, S, Laurent, F, Kearns, AM, Kreiswirth, B, Ko, KS, Grundmann, H, Sollid, JE, John, JF, Daum, R, Soderquist, B, Buist, G & Int Working Grp Classification Sta 2012, 'Guidelines for Reporting Novel mecA Gene Homologues' Antimicrobial Agents and Chemotherapy, vol. 56, no. 10, pp. 4997-4999. DOI: 10.1128/AAC.01199-12
Koeser, CU, Ellington, MJ, Cartwright, EJP, Gillespie, SH, Brown, NM, Farrington, M, Holden, MTG, Dougan, G, Bentley, SD, Parkhill, J & Peacock, SJ 2012, 'Routine use of microbial whole genome sequencing in diagnostic and public health microbiology' PLoS Pathogens, vol. 8, no. 8, e1002824. DOI: 10.1371/journal.ppat.1002824
Koeser, CU, Holden, MTG, Ellington, MJ, Cartwright, EJP, Brown, NM, Ogilvy-Stuart, AL, Hsu, LY, Chewapreecha, C, Croucher, NJ, Harris, SR, Sanders, M, Enright, MC, Dougan, G, Bentley, SD, Parkhill, J, Fraser, LJ, Betley, JR, Schulz-Trieglaff, OB, Smith, GP & Peacock, SJ 2012, 'Rapid Whole-Genome Sequencing for Investigation of a Neonatal MRSA Outbreak' New England Journal of Medicine, vol. 366, no. 24, pp. 2267-2275. DOI: 10.1056/NEJMoa1109910
McAdam, PR, Templeton, KE, Edwards, GF, Holden, MTG, Feil, EJ, Aanensen, DM, Bargawi, HJA, Spratt, BG, Bentley, SD, Parkhill, J, Enright, MC, Holmes, A, Girvan, EK, Godfrey, PA, Feldgarden, M, Kearns, AM, Rambaut, A, Robinson, DA & Fitzgerald, JR 2012, 'Molecular tracing of the emergence, adaptation, and transmission of hospital-associated methicillin-resistant Staphylococcus aureus' Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 23, pp. 9107-9112. DOI: 10.1073/pnas.1202869109
Kos, VN, Desjardins, CA, Griggs, A, Cerqueira, G, Van Tonder, A, Holden, MTG, Godfrey, P, Palmer, KL, Bodi, K, Mongodin, EF, Wortman, J, Feldgarden, M, Lawley, T, Gill, SR, Haas, BJ, Birren, B & Gilmore, MS 2012, 'Comparative genomics of vancomycin-resistant Staphylococcus aureus strains and their positions within the clade most commonly associated with methicillin-resistant S. aureus hospital-acquired infection in the United States' mBio, vol. 3, no. 3, e00112-12. DOI: 10.1128/mBio.00112-12
Phillips, PPJ, Gillespie, SH, Boeree, M, Heinrich, N, Aarnoutse, R, McHugh, T, Pletschette, M, Lienhardt, C, Hafner, R, Mgone, C, Zumla, A, Nunn, AJ & Hoelscher, M 2012, 'Innovative Trial Designs Are Practical Solutions for Improving the Treatment of Tuberculosis' Journal of Infectious Diseases, vol. 205, pp. S250-S257. DOI: 10.1093/infdis/jis041
Gillespie, SH & Bamford, K 2012, Medical Microbiology and Infection at a Glance. 4th edn, Wiley-Blackwell, Oxford.
Singh, KP, Brown, M, Murphy, ME & Gillespie, SH 2012, 'Moxifloxacin for tuberculosis' Lancet Infectious Diseases, vol. 12, no. 3, pp. 176-176.
Fatih, FA, Siner, A, Ahmed, A, Woon, LC, Craig, AG, Singh, B, Krishna, S & Cox Singh, J 2012, 'Cytoadherence and virulence - the case of Plasmodium knowlesi malaria' Malaria Journal, vol. 11, 33. DOI: 10.1186/1475-2875-11-33
Logan-Klumpler, FJ, De Silva, N, Boehme, U, Rogers, MB, Velarde, G, McQuillan, JA, Carver, T, Aslett, M, Olsen, C, Subramanian, S, Phan, I, Farris, C, Mitra, S, Ramasamy, G, Wang, H, Tivey, A, Jackson, A, Houston, R, Parkhill, J, Holden, M, Harb, OS, Brunk, BP, Myler, PJ, Roos, D, Carrington, M, Smith, DF, Hertz-Fowler, C & Berriman, M 2012, 'GeneDB-an annotation database for pathogens' Nucleic Acids Research, vol. 40, no. D1, pp. D98-D108. DOI: 10.1093/nar/gkr1032
Castillo-Ramirez, S, Corander, J, Marttinen, P, Aldeljawi, M, Hanage, WP, Westh, H, Boye, K, Gulay, Z, Bentley, SD, Parkhill, J, Holden, MT & Feil, EJ 2012, 'Phylogeographic variation in recombination rates within a global clone of methicillin-resistant Staphylococcus aureus' Genome Biology, vol. 13, no. 12, 126.
Leung, M, Bryson, K, Freystatter, K, Pichon, B, Edwards, G, Charalambous, B & Gillespie, SH 2012, 'Sequetyping: Serotyping Streptococcus pneumoniae by a Single PCR Sequencing Strategy' Journal of Clinical Microbiology, vol. 50, no. 7, pp. 2419-2427. DOI: 10.1128/JCM.06384-11
Honeyborne, I, McHugh, TD, Phillips, P, Bannoo, S, Bateson, A, Carroll, N, Perrin, F, Ronacher, K, Wright, L, van Helden, P, Walzl, G & Gillespie, SH 2011, 'Molecular Bacterial Load Assay, a Culture-Free Biomarker for Rapid and Accurate Quantification of Sputum Mycobacterium tuberculosis Bacillary Load during Treatment' Journal of Clinical Microbiology, vol. 49, no. 11, pp. 3905-3911. DOI: 10.1128/JCM.00547-11
Chantratita, N, Rholl, DA, Sim, B, Wuthiekanun, V, Limmathurotsakul, D, Amornchai, P, Thanwisai, A, Chua, HH, Ooi, WF, Holden, MTG, Day, NP, Tan, P, Schweizer, HP & Peacock, SJ 2011, 'Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei' Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 41, pp. 17165-17170. DOI: 10.1073/pnas.1111020108
Heilbronner, S, Holden, MTG, van Tonder, A, Geoghegan, JA, Foster, TJ, Parkhill, J & Bentley, SD 2011, 'Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors' FEMS Microbiology Letters, vol. 322, no. 1, pp. 60-67. DOI: 10.1111/j.1574-6968.2011.02339.x
Garcia-Alvarez, L, Holden, MTG, Lindsay, H, Webb, CR, Brown, DFJ, Curran, MD, Walpole, E, Brooks, K, Pickard, DJ, Teale, C, Parkhill, J, Bentley, SD, Edwards, GF, Girvan, EK, Kearns, AM, Pichon, B, Hill, RLR, Larsen, AR, Skov, RL, Peacock, SJ, Maskell, DJ & Holmes, MA 2011, 'Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study' Lancet Infectious Diseases, vol. 11, no. 8, pp. 595-603. DOI: 10.1016/S1473-3099(11)70126-8
Castillo-Ramirez, S, Harris, SR, Holden, MTG, He, M, Parkhill, J, Bentley, SD & Feil, EJ 2011, 'The impact of recombination on dN/dS within recently emerged bacterial clones' PLoS Pathogens, vol. 7, no. 7, e1002129. DOI: 10.1371/journal.ppat.1002129
Cox-Singh, J, Singh, B, Daneshvar, C, Planche, T, Parker-Williams, J, Krishna, S & Cox Singh, J 2011, 'Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections' PLoS One, vol. 6, no. 6, e20541. DOI: 10.1371/journal.pone.0020541
van Ingen, J, Aarnoutse, RE, Donald, PR, Diacon, AH, Dawson, R, van Balen, GP, Gillespie, SH & Boeree, MJ 2011, 'Why Do We Use 600 mg of Rifampicin in Tuberculosis Treatment?' Clinical Infectious Diseases, vol. 52, no. 9, pp. E194-E199. DOI: 10.1093/cid/cir184
Lee, K-S, Divis, PCS, Zakaria, SK, Matusop, A, Julin, RA, Conway, DJ, Cox Singh, J & Singh, B 2011, 'Plasmodium knowlesi: reservoir hosts and tracking the emergence in humans and macaques' PLoS Pathogens, vol. 7, no. 4, e1002015. DOI: 10.1371/journal.ppat.1002015
Arnold, IC, Zigova, Z, Holden, M, Lawley, TD, Rad, R, Dougan, G, Falkow, S, Bentley, SD & Mueller, A 2011, 'Comparative whole genome sequence analysis of the carcinogenic bacterial model pathogen Helicobacter felis' Genome Biology and Evolution, vol. 3, pp. 302-308. DOI: 10.1093/gbe/evr022
Holt, DC, Holden, MTG, Tong, SYC, Castillo-Ramirez, S, Clarke, L, Quail, MA, Currie, BJ, Parkhill, J, Bentley, SD, Feil, EJ & Giffard, PM 2011, 'A Very Early-Branching Staphylococcus aureus Lineage Lacking the Carotenoid Pigment Staphyloxanthin' Genome Biology and Evolution, vol. 3, pp. 881-895. DOI: 10.1093/gbe/evr078
Gillespie, SH & Singh, K 2011, Fluoroquinolones in the management of tuberculosis. in P Donald & P van Helden (eds), Anti-tuberculosis Chemotherapy. vol. 40, Progress in Respiratory Research , Karger, Basel, pp. 51-60.
Menzies, S, Rahman, N, Wrightson, J, Davies, H, Shorten, R, Gillespie, SH, Davies, C, Maskell, N, Jeffrey, A, Lee, G & Davies, R 2011, 'Blood culture bottle culture of pleural fluid in pleural infection' Thorax, vol. 66, no. 8, pp. 658-662. DOI: 10.1136/thx.2010.157842
Dowling, AJ, Wilkinson, PA, Holden, MTG, Quail, MA, Bentley, SD, Reger, J, Waterfield, NR, Titball, RW & Ffrench-Constant, RH 2010, 'Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen Burkholderia pseudomallei K96243' PLoS One, vol. 5, no. 12, 15693. DOI: 10.1371/journal.pone.0015693
Perrin FRM, F, Woodward, N, Phillips, P, McHugh, T, Nunn, A, Lipman, M & Gillespie, SH 2010, 'Radiological cavitation, sputum mycobacterial load and treatment response in pulmonary tuberculosis' International Journal of Tuberculosis and Lung Disease, vol. 14, no. 12, pp. 1596-1602.
Priestnall, SL, Erles, K, Brooks, HW, Cardwell, JM, Waller, AS, Paillot, R, Robinson, C, Darby, AC, Holden, MTG & Schoeniger, S 2010, 'Characterization of Pneumonia Due to Streptococcus equi subsp. zooepidemicus in Dogs' Clinical and Vaccine Immunology, vol. 17, no. 11, pp. 1790-1796. DOI: 10.1128/CVI.00188-10
Paillot, R, Darby, AC, Robinson, C, Wright, NL, Steward, KF, Anderson, E, Webb, K, Holden, MTG, Efstratiou, A, Broughton, K, Jolley, KA, Priestnall, SL, Campi, MCM, Hughes, MA, Radford, A, Erles, K & Waller, AS 2010, 'Identification of Three Novel Superantigen-Encoding Genes in Streptococcus equi subsp zooepidemicus, szeF, szeN, and szeP' Infection and Immunity, vol. 78, no. 11, pp. 4817-4827. DOI: 10.1128/IAI.00751-10
Cox-Singh, J & Cox Singh, J 2010, 'Malaria: what can apes teach humans?' Future Microbiology, vol. 5, no. 8, pp. 1157-1160. DOI: 10.2217/FMB.10.86
Sonthayanon, P, Peacock, SJ, Chierakul, W, Wuthiekanun, V, Blacksell, SD, Holden, MTG, Bentley, SD, Feil, EJ, Day, NPJ & Holden, M 2010, 'High Rates of Homologous Recombination in the Mite Endosymbiont and Opportunistic Human Pathogen Orientia tsutsugamushi' PLoS Neglected Tropical Diseases, vol. 4, no. 7, 752. DOI: 10.1371/journal.pntd.0000752
Ahouidi, AD, Bei, AK, Neafsey, DE, Sarr, O, Volkman, S, Milner, D, Cox-Singh, J, Ferreira, MU, Ndir, O, Premji, Z, Mboup, S, Duraisingh, MT & Cox Singh, J 2010, 'Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens' Infection Genetics and Evolution, vol. 10, no. 2, pp. 200-206. DOI: 10.1016/j.meegid.2009.11.008
Holden, MTG, Lindsay, JA, Corton, C, Quail, MA, Cockfield, JD, Pathak, S, Batra, R, Parkhill, J, Bentley, SD & Edgeworth, JD 2010, 'Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)' Journal of Bacteriology, vol. 192, no. 3, pp. 888-892. DOI: 10.1128/JB.01255-09
Harris, SR, Feil, EJ, Holden, MTG, Quail, MA, Nickerson, EK, Chantratita, N, Gardete, S, Tavares, A, Day, N, Lindsay, JA, Edgeworth, JD, de Lencastre, H, Parkhill, J, Peacock, SJ & Bentley, SD 2010, 'Evolution of MRSA During Hospital Transmission and Intercontinental Spread' Science, vol. 327, no. 5964, pp. 469-474. DOI: 10.1126/science.1182395
Cox Singh, J, Hiu, J, Lucas, SB, Divis, PC, Zulkarnaen, M, Chandran, P, Wong, KT, Adem, P, Zaki, SR, Singh, B & Krishna, S 2010, 'Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report' Malaria Journal, vol. 9, 10. DOI: 10.1186/1475-2875-9-10
Gillespie, SH, Pope, CF & McHugh, TD 2010, Methods to determine fitness in bacteria. in Methods in Molecular Biology. 2 edn, vol. 642, Springer Science and Business Media, pp. 113-121.
Perrin, FMR, Breen, RAM, McHugh, TD, Gillespie, SH & Lipman, MCI 2009, 'Are patients on treatment for pulmonary TB who stop expectorating sputum genuinely culture negative?' Thorax, vol. 64, no. 11, pp. 1009-1010. DOI: 10.1136/thx.2009.115915
Daneshvar, C, Davis, TME, Cox Singh, J, Rafa'ee, MZ, Zakaria, SK, Divis, PCS & Singh, B 2009, 'Clinical and Laboratory Features of Human Plasmodium knowlesi Infection' Clinical Infectious Diseases, vol. 49, no. 6, pp. 852-860. DOI: 10.1086/605439
Holden, MTG, Hauser, H, Sanders, M, Ngo, TH, Cherevach, I, Cronin, A, Goodhead, I, Mungall, K, Quail, MA, Price, C, Rabbinowitsch, E, Sharp, S, Croucher, NJ, Chieu, TB, Mai, NTH, Diep, TS, Chinh, NT, Kehoe, M, Leigh, JA, Ward, PN, Dowson, CG, Whatmore, AM, Chanter, N, Iversen, P, Gottschalk, M, Slater, JD, Smith, HE, Spratt, BG, Xu, J, Ye, C, Bentley, S, Barrell, BG, Schultsz, C, Maskell, DJ & Parkhill, J 2009, 'Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen streptococcus suis' PLoS One, vol. 4, no. 7, e6072. DOI: 10.1371/journal.pone.0006072
Jenkins, C, Bacon, J, Allnutt, J, Hatch, KA, Bose, A, O'Sullivan, DM, Arnold, C, Gillespie, SH & McHugh, TD 2009, 'Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH' Journal of Antimicrobial Chemotherapy, vol. 63, no. 6, pp. 1118-1120. DOI: 10.1093/jac/dkp125
Al-Balas, Q, Anthony, NG, Al-Jaidi, B, Alnimr, A, Abbott, G, Brown, AK, Taylor, RC, Besra, GS, McHugh, TD, Gillespie, SH, Johnston, BF, Mackay, SP & Coxon, GD 2009, 'Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH' PLoS One, vol. 4, no. 5, pp. e5617. DOI: 10.1371/journal.pone.0005617
Holden, MTG, Seth-Smith, HMB, Crossman, LC, Sebaihia, M, Bentley, SD, Cerdeno-Tarraga, AM, Thomson, NR, Bason, N, Quail, MA, Sharp, S, Cherevach, I, Churcher, C, Goodhead, I, Hauser, H, Holroyd, N, Mungall, K, Scott, P, Walker, D, White, B, Rose, H, Iversen, P, Mil-Homens, D, Rocha, EPC, Fialho, AM, Baldwin, A, Dowson, C, Barrell, BG, Govan, JR, Vandamme, P, Hart, CA, Mahenthiralingam, E & Parkhill, J 2009, 'The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients (vol 191, pg 261, 2009)' Journal of Bacteriology, vol. 191, no. 8, pp. 2907-2907. DOI: 10.1128/JB.00168-09
Amin, AK, Manuel, RJ, Ison, CA, Woodham, R, Shemko, M, Maguire, H, Giraudon, I, Forde, J & Gillespie, SH 2009, 'Audit of laboratory diagnostic methods for syphilis in England and Wales' Sexually Transmitted Infections, vol. 85, no. 2, pp. 88-91. DOI: 10.1136/sti.2008.033159
Holden, MTG, Heather, Z, Paillot, R, Steward, KF, Webb, K, Ainslie, F, Jourdan, T, Bason, NC, Holroyd, NE, Mungall, K, Quail, MA, Sanders, M, Simmonds, M, Willey, D, Brooks, K, Aanensen, DM, Spratt, BG, Jolley, KA, Maiden, MCJ, Kehoe, M, Chanter, N, Bentley, SD, Robinson, C, Maskell, DJ, Parkhill, J & Waller, AS 2009, 'Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens' PLoS Pathogens, vol. 5, no. 3, e1000346. DOI: 10.1371/journal.ppat.1000346
Myers, WP, Myers, AP, Cox Singh, J, Lau, HC, Mokuai, B & Malley, R 2009, 'Micro-geographic risk factors for malarial infection' Malaria Journal, vol. 8, 27. DOI: 10.1186/1475-2875-8-27
Ward, PN, Holden, MTG, Leigh, JA, Lennard, N, Bignell, A, Barron, A, Clark, L, Quail, MA, Woodward, J, Barrell, BG, Egan, SA, Field, TR, Maskell, D, Kehoe, M, Dowson, CG, Chanter, N, Whatmore, AM, Bentley, SD & Parkhill, J 2009, 'Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis' BMC Genomics, vol. 10, 54. DOI: 10.1186/1471-2164-10-54
Holden, MTG, Seth-Smith, HMB, Crossman, LC, Sebaihia, M, Bentley, SD, Cerdeno-Tarraga, AM, Thomson, NR, Bason, N, Quail, MA, Sharp, S, Cherevach, I, Churcher, C, Goodhead, I, Hauser, H, Holroyd, N, Mungall, K, Scott, P, Walker, D, White, B, Rose, H, Iversen, P, Mil-Homens, D, Rocha, EPC, Fialho, AM, Baldwin, A, Dowson, C, Barrell, BG, Govan, JR, Vandamme, P, Hart, CA, Mahenthiralingam, E & Parkhill, J 2009, 'The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients' Journal of Bacteriology, vol. 191, no. 1, pp. 261-277. DOI: 10.1128/JB.01230-08
Gillespie, SH & Bamford, K 2009, Medical Microbiology and Infection at a Glance. Third Edition edn, Peneerbit erlangga.
Hjerde, E, Lorentzen, MS, Holden, MTG, Seeger, K, Paulsen, S, Bason, N, Churcher, C, Harris, D, Norbertczak, H, Quail, MA, Sanders, S, Thurston, S, Parkhill, J, Willassen, NP & Thomson, NR 2008, 'The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay' BMC Genomics, vol. 9, 616. DOI: 10.1186/1471-2164-9-616
Heather, Z, Holden, MTG, Steward, KF, Parkhill, J, Song, L, Challis, GL, Robinson, C, Davis-Poynter, N & Waller, AS 2008, 'A novel streptococcal integrative conjugative element involved in iron acquisition' Molecular Microbiology, vol. 70, no. 5, pp. 1274-1292. DOI: 10.1111/j.1365-2958.2008.06481.x
Davies, AP, Dhillon, AP, Young, M, Henderson, B, McHugh, TD & Gillespie, SH 2008, 'Resuscitation-promoting factors are expressed in Mycobacterium tuberculosis-infected human tissue' Tuberculosis, vol. 88, no. 5, pp. 462-468. DOI: 10.1016/
Tumapa, S, Holden, MTG, Vesaratchavest, M, Wuthiekanun, V, Limmathurotsakul, D, Chierakul, W, Feil, EJ, Currie, BJ, Day, NPJ, Nierman, WC & Peacock, SJ 2008, 'Burkholderia pseudomallei genome plasticity associated with genomic island variation' BMC Genomics, vol. 9, 190. DOI: 10.1186/1471-2164-9-190
Cox Singh, J, Davis, TME, Lee, K-S, Shamsul, SSG, Matusop, A, Ratnam, S, Rahman, HA, Conway, DJ & Singh, B 2008, 'Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening' Clinical Infectious Diseases, vol. 46, no. 2, pp. 165-171. DOI: 10.1086/524888
Thomson, NR, Holden, MTG, Carder, C, Lennard, N, Lockey, SJ, Marsh, P, Skipp, P, O'Connor, CD, Goodhead, I, Norbertzcak, H, Harris, B, Ormond, D, Rance, R, Quail, MA, Parkhill, J, Stephens, RS & Clarke, IN 2008, 'Chlamydia trachomatis: Genome sequence analysis of lymphogranuloma venereum isolates' Genome Research, vol. 18, no. 1, pp. 161-171. DOI: 10.1101/gr.7020108
Breen, RAM, Barry, SM, Smith, CJ, Shorten, RJ, Dilworth, JP, Cropley, I, McHugh, TD, Gillespie, SH, Janossy, G & Lipman, MCI 2008, 'Clinical application of a rapid lung-orientated immunoassay in individuals with possible tuberculosis' Thorax, vol. 63, no. 1, pp. 67-71. DOI: 10.1136/thx.2007.078857
O'Sullivan, DM, Sander, C, Shorten, RJ, Gillespie, SH, Hill, AVS, McHugh, TD, McShane, H & Tchilian, EZ 2007, 'Evaluation of liquid culture for quantitation of Mycobacterium tuberculosis in murine models' Vaccine, vol. 25, no. 49, pp. 8203-8205. DOI: 10.1016/j.vaccine.2007.09.065