INFECTION AND GLOBAL HEALTH RESEARCH DIVISION

Research at the University of St Andrews School of Medicine

Publications

Infection group recent publications

Recent publications listed in research@st-andrews

Hao, L, Holden, MTG, Wang, X, Andrew, L, Wellnitz, S, Hu, F, Whaley, M, Sammons, S, Knipe, K, Frace, M, McNamara, LA, Liberator, P & Anderson, AS 2018, 'Distinct evolutionary patterns of Neisseria meningitidis serogroup B disease outbreaks at two universities in the USA' Microbial Genomics. DOI: 10.1099/mgen.0.000155
Rachow, A, Saathoff, E, Mtafya, B, Mapamba, D, Mangu, C, Rojas-Ponce, G, Ntinginya, NE, Boeree, M, Heinrich, N, Gillespie, SH, Hoelscher, M & on behalf of the PanACEA-Consortium 2018, 'The impact of repeated NALC/NaOH- decontamination on the performance of Xpert MTB/RIF assay' Tuberculosis, vol In press. DOI: 10.1016/j.tube.2018.04.001
Fregonese, F, Ahuja, SD, Akkerman, OW, Arakaki-Sanchez, D, Ayakaka, I, Baghaei, P, Bang, D, Bastos, M, Benedetti, A, Bonnet, M, Cattamanchi, A, Cegielski, P, Chien, J-Y, Cox, H, Dedicoat, M, Erkens, C, Escalante, P, Falzon, D, Garcia-Prats, AJ, Gegia, M, Gillespie, SH, Glynn, JR, Goldberg, S, Griffith, D, Jacobson, KR, Johnston, JC, Jones-López, EC, Khan, A, Koh, W-J, Kritski, A, Lan, ZY, Lee, JH, Li, PZ, Maciel, EL, Galliez, RM, Merle, CSC, Munang, M, Narendran, G, Nguyen, VN, Nunn, A, Ohkado, A, Park, JS, Phillips, PPJ, Ponnuraja, C, Reves, R, Romanowski, K, Seung, K, Schaaf, HS, Skrahina, A, Soolingen, DV, Tabarsi, P, Trajman, A, Trieu, L, Banurekha, VV, Viiklepp, P, Wang, J-Y, Yoshiyama, T & Menzies, D 2018, 'Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis' The Lancet Respiratory Medicine, vol 6, no. 4, pp. 265-275. DOI: 10.1016/S2213-2600(18)30078-X
Bossé, JT, Li, Y, Sárközi, R, Fodor, L, Lacouture, S, Gottschalk, M, Amoribieta, MC, Angen, Ø, Nedbalcova, K, Holden, MTG, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & on behalf of the BRaDP1T consortium 2018, 'Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis' Veterinary Microbiology, vol 217, pp. 1-6. DOI: 10.1016/j.vetmic.2018.02.019
Tweed, CD, Wills, GH, Crook, AM, Dawson, R, Diacon, AH, Louw, CE, McHugh, TD, Mendel, C, Meredith, S, Mohapi, L, Murphy, ME, Murray, S, Murthy, S, Nunn, AJ, Phillips, PPJ, Singh, K, Spigelman, M & Gillespie, SH 2018, 'Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study' BMC Medicine, vol 16, 46. DOI: 10.1186/s12916-018-1033-7
Baron, VO, Chen, M, Clark, SO, Williams, A, Dholakia, K & Gillespie, SH 2018, Detecting phenotypically resistant Mycobacterium tuberculosis using wavelength modulated Raman spectroscopy. in S Gillespie (ed.), Antibiotic Resistance Protocols. Methods in Molecular Biology, vol. 1736, Humana Press/Springer, New York, NY, pp. 41-50. DOI: 10.1007/978-1-4939-7638-6_4
Hammond, RJH, Baron, VO, Lipworth, S & Gillespie, SH 2018, Enhanced methodologies for detecting phenotypic resistance in mycobacteria. in S Gillespie (ed.), Antibiotic Resistance Protocols. Methods in Molecular Biology, vol. 1736, Humana Press/Springer, New York, NY, pp. 85-94. DOI: 10.1007/978-1-4939-7638-6_8
Xaio, H & Gillespie, SH 2018, Using RT qPCR for quantifying Mycobacteria marinum from in vitro and in vivo samples. in S Gillespie (ed.), Antibiotic Resistance Protocols. Methods in Molecular Biology, vol. 1736, Humana Press/Springer, New York, NY, pp. 137-145. DOI: 10.1007/978-1-4939-7638-6_13
Casabona, MG, Kneuper, H, Alferes de Lima, D, Harkins, CP, Zoltner, M, Hjerde, E, Holden, MTG & Palmer, T 2017, 'Haem-iron plays a key role in the regulation of the Ess/type VII secretion system of Staphylococcus aureus RN6390' Microbiology, vol Latest Article. DOI: 10.1099/mic.0.000579
Casabona, MG, Buchanan, G, Zoltner, M, Harkins, CP, Holden, MTG & Palmer, T 2017, 'Functional analysis of the EsaB component of the Staphylococcus aureus Type VII secretion system' Microbiology, vol Latest Article. DOI: 10.1099/mic.0.000580
Aarnoutse, RE, Kibiki, GS, Reither, K, Semvua, HH, Haraka, F, Mtabho, CM, Mpagama, SG, van den Boogaard, J, Sumari-de Boer, IM, Magis-Escurra, C, Wattenberg, M, Logger, JGM, te Brake, LHM, Hoelscher, M, Gillespie, SH, Colbers, A, Phillips, PPJ, Plemper van Balen, G, Boeree, MJ & PanACEA Consortium 2017, 'Pharmacokinetics, tolerability, and bacteriological response of rifampin administered at 600, 900, and 1,200 milligrams daily in patients with pulmonary tuberculosis' Antimicrobial Agents and Chemotherapy, vol 61, no. 11, e01054-17. DOI: 10.1128/AAC.01054-17
Murphy, ME, Phillips, PPJ, Mendel, CM, Bongard, E, Bateson, ALC, Hunt, R, Murthy, S, Singh, KP, Brown, M, Crook, AM, Nunn, AJ, Meredith, SK, Lipman, M, McHugh, TD, Gillespie, SH & on behalf of the REMoxTB Consortium 2017, 'Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis' BMC Medicine, vol 15, 192. DOI: 10.1186/s12916-017-0947-9
Harkins, CP, Pettigrew, KA, Oravcova, K, Gardner, J, Hearn, R, Rice, D, Mather, AE, Parkhill, J, Brown, SJ, Proby, CM & Holden, MT 2017, 'The genetic diversity of Staphylococcus aureus colonisation in atopic eczema disease flare' Journal of Investigative Dermatology, vol 137, no. 10, pp. S258-S258.
Walsh, SLF, Maher, TM, Kolb, M, Poletti, V, Nusser, R, Richeldi, L, Vancheri, C, Wilsher, ML, Antoniou, KM, Behr, J, Bendstrup, E, Brown, K, Calandriello, L, Corte, TJ, Cottin, V, Crestani, B, Flaherty, K, Glaspole, I, Grutters, J, Inoue, Y, Kokosi, M, Kondoh, Y, Kouranos, V, Kreuter, M, Johannson, K, Judge, E, Ley, B, Margaritopoulos, G, Martinez, FJ, Molina-Molina, M, Morais, A, Nunes, H, Raghu, G, Ryerson, CJ, Selman, M, Spagnolo, P, Taniguchi, H, Tomassetti, S, Valeyre, D, Wijsenbeek, M, Wuyts, W, Hansell, D, Wells, A, IPF Project Consortium & Dhasmana, DJ 2017, 'Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study' European Respiratory Journal, vol 50, no. 2, 1700936. DOI: 10.1183/13993003.00936-2017
Sarovich, DS, Chapple, SNJ, Price, EP, Mayo, M, Holden, MTG, Peacock, SJ & Currie, BJ 2017, 'Whole-genome sequencing to investigate a non-clonal melioidosis cluster on a remote Australian island' Microbial Genomics, vol 3, no. 8, e000117. DOI: 10.1099/mgen.0.000117
Björnsdóttir, S, Harris, SR, Svansson, V, Gunnarsson, E, Sigurðardóttir, ÓG, Gammeljord, K, Steward, KF, Newton, JR, Robinson, C, Charbonneau, ARL, Parkhill, J, Holden, MTG & Waller, AS 2017, 'Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases' mBio, vol 8, no. 4, e00826-17. DOI: 10.1128/mBio.00826-17
Hsu, L-Y, Holden, MTG, Koh, TH, Pettigrew, KA, Cao, D, Hon, PY, Sergio, DM, Pena, E & Ogden, BE 2017, 'ST3268: a geographically widespread primate MRSA clone' Journal of Antimicrobial Chemotherapy, vol 72, no. 8, pp. 2401-2403. DOI: 10.1093/jac/dkx120
Harkins, CP, Pichon, B, Doumith, M, Parkhill, J, Westh, H, Tomasz, A, de Lencastre, H, Bentley, SD, Kearns, AM & Holden, MTG 2017, 'Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice' Genome Biology, vol 18, 130. DOI: 10.1186/s13059-017-1252-9
Donker, T, Reuter, S, Scriberras, J, Reynolds, R, Brown, NM, Török, ME, James, R, Network, EOEMR, Aanensen, DM, Bentley, SD, Holden, MTG, Parkhill, J, Spratt, BG, Peacock, SJ, Feil, EJ & Grundmann, H 2017, 'Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns' Microbial Genomics, vol 3, no. 7, e000113. DOI: 10.1099/mgen.0.000113
Kalimuddin, S, Chen, SL, Lim, CTK, Koh, TH, Tan, TY, Kam, M, Wong, CW, Mehershahi, KS, Chau, ML, Ng, LC, Tang, WY, Badaruddin, H, Teo, J, Apisarnthanarak, A, Suwantarat, N, Ip, M, Holden, MTG, Hsu, LY, Barkham, T & for the Singapore Group B Streptococcus Consortium 2017, '2015 epidemic of severe Streptococcus agalactiae sequence type 283 infections in Singapore associated with the consumption of raw freshwater fish: a detailed analysis of clinical, epidemiological, and bacterial sequencing data' Clinical Infectious Diseases, vol 64, no. suppl_2, pp. S145-S152. DOI: 10.1093/cid/cix021
Chow, A, Lim, VW, Khan, A, Pettigrew, K, Lye, DCB, Kanagasabai, K, Phua, K, Krishnan, P, Ang, B, Marimuthu, K, Hon, P-Y, Koh, J, Leong, I, Parkhill, J, Hsu, L-Y & Holden, MTG 2017, 'MRSA transmission dynamics among interconnected acute, intermediate-term, and long-term healthcare facilities in Singapore' Clinical Infectious Diseases, vol 64, no. suppl_2, pp. S76-S81. DOI: 10.1093/cid/cix072
Kayria, M, Chris, O, Dhasmana, DJ, Nilesh, M, Hodson, ME, Khin, G, Diana, B & Simmonds, NJ 2017, 'Burkholderia cepacia complex and limited cutaneous vasculitis in patients with cystic fibrosis: a case series' JRSM Open, vol 8, no. 4, pp. 1-4. DOI: 10.1177/2054270417692732
Bossé, JT, Li, Y, Rogers, J, Crespo, RF, Li, Y, Chaudhuri, RR, Holden, MTG, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & BRaDP1T Consortium 2017, 'Whole genome sequencing for surveillance of antimicrobial resistance in Actinobacillus pleuropneumoniae' Frontiers in Microbiology, vol 8, 311. DOI: 10.3389/fmicb.2017.00311
Muliaditan, M, Davies, GR, Simonsson, USH, Gillespie, SH & Pasqua, OD 2017, 'The implications of model–informed drug discovery and development for tuberculosis' Drug Discovery Today, vol 22, no. 3, pp. 481-486. DOI: 10.1016/j.drudis.2016.09.004
Chewapreecha, C, Holden, MTG, Vehkala, M, Välimäki, N, Yang, Z, Harris, SR, Mather, AE, Tuanyok, A, De Smet, B, Le Hello, S, Bizet, C, Mayo, M, Wuthiekanun, V, Limmathurotsakul, D, Phetsouvanh, R, Spratt, BG, Corander, J, Keim, P, Dougan, G, Dance, DAB, Currie, BJ, Parkhill, J & Peacock, SJ 2017, 'Global and regional dissemination and evolution of Burkholderia pseudomallei' Nature Microbiology, vol 2, 16263. DOI: 10.1038/nmicrobiol.2016.263
Ellington, MJ, Ekelund, O, Aarestrup, FM, Canton, R, Doumith, M, Giske, C, Grundman, H, Hasman, H, Holden, MTG, Hopkins, KL, Iredell, J, Kahlmeter, G, Köser, CU, MacGowan, A, Mevius, D, Mulvey, M, Naas, T, Peto, T, Rolain, J-M, Samuelsen, Ø & Woodford, N 2017, 'The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee' Clinical Microbiology and Infection, vol 23, no. 1, pp. 2-22. DOI: 10.1016/j.cmi.2016.11.012
Boeree, MJ, Heinrich, N, Aarnoutse, R, Diacon, AH, Dawson, R, Rehal, S, Kibiki, GS, Churchyard, G, Sanne, I, Ntinginya, NE, Minja, LT, Hunt, RD, Charalambous, S, Hanekom, M, Semvua, HH, Mpagama, SG, Manyama, C, Mtafya, B, Reither, K, Wallis, RS, Venter, A, Narunsky, K, Mekota, A, Henne, S, Colbers, A, Plemper van Balen, G, Gillespie, SH, Phillips, PPJ & Hoelscher, M 2017, 'High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial' Lancet Infectious Diseases, vol 17, no. 1, pp. 39-49. DOI: 10.1016/S1473-3099(16)30274-2, 10.1016/S1473-3099(16)30274-2
Gillespie, SH, Sabiiti, W & Oravcova, K 2017, Mycobacterial load assay. in KA Bishop-Lilly (ed.), Diagnostic Bacteriology: Methods and Protocols. Methods in Molecular Biology, vol. 1616, Humana Press/Springer, New York, NY, pp. 89-105. DOI: 10.1007/978-1-4939-7037-7_5
Afshar, B, Turner, CE, Lamagni, T, Smith, K, Al-Shahib, A, Underwood, A, Holden, MTG, Efstratiou, A & Sriskandan, S 2017, 'Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus' Virulence, vol 8, no. 7, pp. 1390-1400. DOI: 10.1080/21505594.2017.1325070
Aliberti, S, Reyes, LF, Faverio, P, Sotgiu, G, Dore, S, Rodriguez, AH, Soni, NJ, Restrepo, MI, on behalf of the GLIMP investigators & Dhasmana, DJ 2016, 'Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study' Lancet Infectious Diseases, vol 16, no. 12, pp. 1364-1376. DOI: 10.1016/S1473-3099(16)30267-5
Argimón, S, Abudahab, K, Goater, RJE, Fedosejev, A, Bhai, J, Glasner, C, Feil, EJ, Holden, MTG, Yeats, CA, Grundmann, H, Spratt, BG & Aanensen, DM 2016, 'Microreact: visualizing and sharing data for genomic epidemiology and phylogeography' Microbial Genomics, vol 2, no. 11. DOI: 10.1099/mgen.0.000093
Sabiiti, W, Mtafya, B, Kuchaka, D, Azam, K, Viegas, S, Mdolo, A, Farmer, E, Khonga, M, Evangelopoulos, D, Honeyborne, I, Rachow, A, Heinrich, N, Ntinginya, NE, Bhatt, N, Davies, GR, Jani, IV, McHugh, TD, Kibiki, G, Hoelscher, M, Gillespie, SH & on behalf of the PANBIOME (Pan-African Biomarker Expansion Programme) consortium 2016, 'Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings' International Journal of Tuberculosis and Lung Disease, vol 20, no. 8, pp. 1004-1009. DOI: 10.5588/ijtld.15.0951
Chapple, SNJ, Sarovich, DS, Holden, MTG, Peacock, SJ, Buller, N, Golledge, C, Currie, BJ, Mayo, M & Price, EP 2016, 'Whole-genome sequencing of a quarter-century melioidosis outbreak in temperate Australia uncovers a region of low-prevalence endemicity' Microbial Genomics, vol 2, no. 7. DOI: 10.1099/mgen.0.000067
Lipworth, S, Hammond, RJH, Baron, VO, Hu, Y, Coates, A & Gillespie, SH 2016, 'Defining dormancy in mycobacterial disease' Tuberculosis, vol 99, pp. 131-142. DOI: 10.1016/j.tube.2016.05.006
Bosse, JT, Li, Y, Crespo, RF, Chaudhuri, RR, Rogers, J, Holden, MTG, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & BRaDP1T Consortium 2016, 'ICEApl1, an integrative conjugative element related to ICEHin1056, identified in the pig pathogen Actinobacillus pleuropneumoniae' Frontiers in Microbiology, vol 7, 810. DOI: 10.3389/fmicb.2016.00810
Boeree, MJ, Gillespie, SH, Hoelscher, M & PanACEA core team 2016, 'Therapy for Tuberculous Meningitis' New England Journal of Medicine, vol 374, no. 22, pp. 2187-8. DOI: 10.1056/NEJMc1602291#SA2
Jamrozy, DM, Harris, SR, Mohamed, N, Peacock, SJ, Tan, CY, Parkhill, J, Anderson, AS & Holden, MTG 2016, 'Pan-genomic perspective on the evolution of the Staphylococcus aureus USA300 epidemic' Microbial Genomics, vol 2, no. 5, pp. 1-14. DOI: 10.1099/mgen.0.000058
Dhasmana, DJ, Harrison, F, Hartley, T & Szapiro, D 2016, 'Evaluation of the healthcare burden of Idiopathic Pulmonary Fibrosis (IPF) in Fife, Scotland' American Thoracic Society Conference 2016, San Francisco, United States, 13/05/16 - 18/05/16, .
Aanensen, DM, Feil, EJ, Holden, MTG, Dordel, J, Yeats, CA, Fedosejev, A, Goater, R, Castillo-Ramírez, S, Corander, J, Colijn, C, Chlebowicz, MA, Schouls, L, Heck, M, Pluister, G, Ruimy, R, Kahlmeter, G, Åhman, J, Matuschek, E, Friedrich, AW, Parkhill, J, Bentley, SD, Spratt, BG, Grundmann, H & European Staphylococcal Reference Laboratory Working Group 2016, 'Whole-genome sequencing for routine pathogen surveillance in public health: a population snapshot of invasive Staphylococcus aureus in Europe' mBio, vol 7, no. 3, e00444-16, pp. 1-15. DOI: 10.1128/mBio.00444-16
Honeyborne, I, McHugh, TD, Kuittinen, I, Cichonska, A, Evangelopoulos, D, Ronacher, K, van Helden, PD, Gillespie, SH, Fernandez-Reyes, D, Walzl, G, Rousu, J, Butcher, PD & Waddell, SJ 2016, 'Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy' BMC Medicine, vol 14, no. 1, pp. 1-13. DOI: 10.1186/s12916-016-0609-3
Phillips, PPJ, Dooley, KE, Gillespie, SH, Heinrich, N, Stout, JE, Nahid, P, Diacon, AH, Aarnoutse, RE, Kibiki, GS, Boeree, MJ & Hoelscher, M 2016, 'A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP)' BMC Medicine, vol 14, 51, pp. 1-11. DOI: 10.1186/s12916-016-0597-3
Warne, B, Harkins, CP, Harris, SR, Vatsiou, A, Stanley-Wall, N, Parkhill, J, Peacock, SJ, Palmer, T & Holden, MTG 2016, 'The Ess/Type VII secretion system of Staphylococcus aureus shows unexpected genetic diversity' BMC Genomics, vol 17, no. 1, pp. 222. DOI: 10.1186/s12864-016-2426-7
Reuter, S, Török, EM, Holden, MT, Reynolds, R, Raven, KE, Blane, B, Donker, T, Bentley, SD, Aanensen, DM, Grundmann, H, Feil, EJ, Spratt, BG, Parkhill, J & Peacock, SJ 2016, 'Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland' Genome Research, vol 26, no. 2, pp. 263-270. DOI: 10.1101/gr.196709.115
Bossé, JT, Chaudhuri, RR, Li, Y, Leanse, LG, Fernandez Crespo, R, Coupland, P, Holden, MTG, Bazzolli, DM, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & on behalf of the BRaDP1T consortium 2016, 'Complete genome sequence of MIDG2331, a genetically tractable serovar 8 clinical isolate of Actinobacillus pleuropneumoniae' Genome Announcements, vol 4, no. 1, e01667-15. DOI: 10.1128/genomeA.01667-15
Ba, X, Harrison, EM, Lovering, AL, Gleadall, N, Zadoks, R, Parkhill, J, Peacock, SJ, Holden, MTG, Paterson, GK & Holmes, MA 2015, 'Old drugs to treat resistant bugs: methicillin-resistant Staphylococcus aureus isolates with mecC are susceptible to a combination of penicillin and clavulanic acid' Antimicrobial Agents and Chemotherapy, vol 59, no. 12, pp. 7396-7404. DOI: 10.1128/AAC.01469-15
Donald, I, Meyer, K, Gillespie, SH, Bowness, R & Brengman, J 2015, Project Sanitarium: gaming TB - A serious game for a serious problem. in 7th International Conference on Games and Virtual Worlds for Serious Applications, VS-Games 2015., 7295782, IEEE, Seventh International Conference on Virtual Worlds and Games for Serious Applications: VS-Games 2015, University of Skövde, Sweden, 16/09/15. DOI: 10.1109/VS-GAMES.2015.7295782
Laabei, M, Uhlemann, A-C, Lowy, FD, Austin, ED, Yokoyama, M, Ouadi, K, Feil, E, Thorpe, HA, Williams, B, Perkins, M, Peacock, SJ, Clarke, SR, Dordel, J, Holden, M, Votintseva, AA, Bowden, R, Crook, DW, Young, BC, Wilson, DJ, Recker, M & Massey, RC 2015, 'Evolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureus' PLoS Biology, vol 13, no. 9, e1002229. DOI: 10.1371/journal.pbio.1002229
Harris, SR, Robinson, C, Steward, KF, Webb, KS, Paillot, R, Parkhill, J, Holden, MTG & Waller, AS 2015, 'Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection' Genome Research, vol 25, no. 9, pp. 1360-1371. DOI: 10.1101/gr.189803.115
Boeree, MJ, Diacon, AH, Dawson, R, Narunsky, K, du Bois, J, Venter, A, Phillips, PPJ, Gillespie, SH, McHugh, TD, Hoelscher, M, Heinrich, N, Rehal, S, van Soolingen, D, van Ingen, J, Magis-Escurra, C, Burger, D, Plemper van Balen, G & Aarnoutse, RE 2015, 'A Step toward an Optimized Rifampin Dose Completed' American Journal of Respiratory and Critical Care Medicine, vol 192, no. 4, pp. 525-6. DOI: 10.1164/rccm.201506-1061LE
Bossé, JT, Li, Y, Atherton, TG, Walker, S, Williamson, SM, Rogers, J, Chaudhuri, RR, Weinert, LA, Holden, MTG, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & on behalf of BraDP1T consortium 2015, 'Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae' Veterinary Microbiology, vol 178, no. 3-4, pp. 279-82. DOI: 10.1016/j.vetmic.2015.05.020
Bossé, JT, Li, Y, Walker, S, Atherton, T, Fernandez Crespo, R, Williamson, SM, Rogers, J, Chaudhuri, RR, Weinert, LA, Oshota, O, Holden, M, Maskell, DJ, Tucker, AW, Wren, BW, Rycroft, AN, Langford, PR & BRaDP1T Consortium 2015, 'Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae' Journal of Antimicrobial Chemotherapy, vol 70, no. 8, pp. 2217-2222. DOI: 10.1093/jac/dkv121
Turner, CE, Abbott, J, Lamagni, T, Holden, M, David, S, Jones, MD, Game, L, Efstratiou, A & Sriskandan, S 2015, 'Emergence of a new highly successful acapsular Group A Streptococcus clade of the genotype emm89 in the United Kingdom' mBio, vol 6, no. 4, e00622-15. DOI: 10.1128/mBio.00622-15
Honeyborne, I, Lipman, MC, Eckold, C, Evangelopoulos, D, Gillespie, SH, Pym, A & McHugh, TD 2015, 'Effective anti-tuberculosis therapy correlates with plasma small RNA' European Respiratory Journal, vol 45, no. 6, pp. 1741-1744. DOI: 10.1183/09031936.00221214
Steinig, EJ, Andersson, P, Harris, SR, Sarovich, DS, Manoharan, A, Coupland, P, Holden, MT, Parkhill, J, Bentley, SD, Robinson, DA & Tong, SY 2015, 'Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus' BMC Genomics, vol 16, 388. DOI: 10.1186/s12864-015-1599-9
Reynolds, C, Goudet, A, Jenjaroen, K, Sumonwiriya, M, Rinchai, D, Musson, J, Overbeek, S, Makinde, J, Quigley, K, Manji, J, Spink, N, Yos, P, Wuthiekanun, V, Bancroft, G, Robinson, J, Lertmemongkolchai, G, Dunachie, S, Maillere, B, Holden, M, Altmann, D & Boyton, R 2015, 'T cell immunity to the alkyl hydroperoxide reductase of Burkholderia pseudomallei: a correlate of disease outcome in acute melioidosis' The Journal of Immunology, vol 194, no. 10, pp. 4814-4824. DOI: 10.4049/jimmunol.1402862
Boeree, MJ, Diacon, AH, Dawson, R, Narunsky, K, du Bois, J, Venter, A, Phillips, PPJ, Gillespie, SH, Mc Hugh, TD, Hoelscher, M, Heinrich, N, Rehal, S, van Soolingen, D, van Ingen, J, Magis-Escurra, C, Burger, D, Plemper van Balen, G & Aarnoutse, RE 2015, 'A dose ranging trial to optimize the dose of Rifampin in the treatment of tuberculosis' American Journal of Respiratory and Critical Care Medicine, vol 191, no. 9, pp. 1058-1065. DOI: 10.1164/rccm.201407-1264OC
Weinert, LA, Chaudhuri, RR, Wang, J, Peters, SE, Corander, J, Jombart, T, Baig, A, Howell, KJ, Vehkala, M, Välimäki, N, Harris, D, Chieu, TTB, Van Vinh Chau, N, Campbell, J, Schultsz, C, Parkhill, J, Bentley, SD, Langford, PR, Rycroft, AN, Wren, BW, Farrar, J, Baker, S, Hoa, NT, Holden, MTG, Tucker, AW, Maskell, DJ & BRaDP1T Consortium 2015, 'Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis' Nature Communications, vol 6, 6740. DOI: 10.1038/ncomms7740
Wikraiphat, C, Saiprom, N, Tandhavanant, S, Heiss, C, Azadi, P, Wongsuvan, G, Tuanyok, A, Holden, M, Burtnick, MN, Brett, PJ, Peacock, SJ & Chantratita, N 2015, 'Colony morphology variation of Burkholderia pseudomallei is associated with antigenic variation and O-polysaccharide modifications' Infection and Immunity, vol 83, no. 5, pp. 2127-2138. DOI: 10.1128/IAI.02785-14
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Singh, KP, Brown, M, Murphy, ME & Gillespie, SH 2012, 'Moxifloxacin for tuberculosis' Lancet Infectious Diseases, vol 12, no. 3, pp. 176-176.
Fatih, FA, Siner, A, Ahmed, A, Woon, LC, Craig, AG, Singh, B, Krishna, S & Cox Singh, J 2012, 'Cytoadherence and virulence - the case of Plasmodium knowlesi malaria' Malaria Journal, vol 11, 33. DOI: 10.1186/1475-2875-11-33
Logan-Klumpler, FJ, De Silva, N, Boehme, U, Rogers, MB, Velarde, G, McQuillan, JA, Carver, T, Aslett, M, Olsen, C, Subramanian, S, Phan, I, Farris, C, Mitra, S, Ramasamy, G, Wang, H, Tivey, A, Jackson, A, Houston, R, Parkhill, J, Holden, M, Harb, OS, Brunk, BP, Myler, PJ, Roos, D, Carrington, M, Smith, DF, Hertz-Fowler, C & Berriman, M 2012, 'GeneDB-an annotation database for pathogens' Nucleic Acids Research, vol 40, no. D1, pp. D98-D108. DOI: 10.1093/nar/gkr1032
Castillo-Ramirez, S, Corander, J, Marttinen, P, Aldeljawi, M, Hanage, WP, Westh, H, Boye, K, Gulay, Z, Bentley, SD, Parkhill, J, Holden, MT & Feil, EJ 2012, 'Phylogeographic variation in recombination rates within a global clone of methicillin-resistant Staphylococcus aureus' Genome Biology, vol 13, no. 12, 126.
Leung, M, Bryson, K, Freystatter, K, Pichon, B, Edwards, G, Charalambous, B & Gillespie, SH 2012, 'Sequetyping: Serotyping Streptococcus pneumoniae by a Single PCR Sequencing Strategy' Journal of Clinical Microbiology, vol 50, no. 7, pp. 2419-2427. DOI: 10.1128/JCM.06384-11
Honeyborne, I, McHugh, TD, Phillips, P, Bannoo, S, Bateson, A, Carroll, N, Perrin, F, Ronacher, K, Wright, L, van Helden, P, Walzl, G & Gillespie, SH 2011, 'Molecular Bacterial Load Assay, a Culture-Free Biomarker for Rapid and Accurate Quantification of Sputum Mycobacterium tuberculosis Bacillary Load during Treatment' Journal of Clinical Microbiology, vol 49, no. 11, pp. 3905-3911. DOI: 10.1128/JCM.00547-11
Chantratita, N, Rholl, DA, Sim, B, Wuthiekanun, V, Limmathurotsakul, D, Amornchai, P, Thanwisai, A, Chua, HH, Ooi, WF, Holden, MTG, Day, NP, Tan, P, Schweizer, HP & Peacock, SJ 2011, 'Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei' Proceedings of the National Academy of Sciences of the United States of America, vol 108, no. 41, pp. 17165-17170. DOI: 10.1073/pnas.1111020108
Garcia-Alvarez, L, Holden, MTG, Lindsay, H, Webb, CR, Brown, DFJ, Curran, MD, Walpole, E, Brooks, K, Pickard, DJ, Teale, C, Parkhill, J, Bentley, SD, Edwards, GF, Girvan, EK, Kearns, AM, Pichon, B, Hill, RLR, Larsen, AR, Skov, RL, Peacock, SJ, Maskell, DJ & Holmes, MA 2011, 'Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study' Lancet Infectious Diseases, vol 11, no. 8, pp. 595-603. DOI: 10.1016/S1473-3099(11)70126-8
Castillo-Ramirez, S, Harris, SR, Holden, MTG, He, M, Parkhill, J, Bentley, SD & Feil, EJ 2011, 'The impact of recombination on dN/dS within recently emerged bacterial clones' PLoS Pathogens, vol 7, no. 7, e1002129. DOI: 10.1371/journal.ppat.1002129
Cox-Singh, J, Singh, B, Daneshvar, C, Planche, T, Parker-Williams, J, Krishna, S & Cox Singh, J 2011, 'Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections' PLoS One, vol 6, no. 6, e20541. DOI: 10.1371/journal.pone.0020541
van Ingen, J, Aarnoutse, RE, Donald, PR, Diacon, AH, Dawson, R, van Balen, GP, Gillespie, SH & Boeree, MJ 2011, 'Why Do We Use 600 mg of Rifampicin in Tuberculosis Treatment?' Clinical Infectious Diseases, vol 52, no. 9, pp. E194-E199. DOI: 10.1093/cid/cir184
Lee, K-S, Divis, PCS, Zakaria, SK, Matusop, A, Julin, RA, Conway, DJ, Cox Singh, J & Singh, B 2011, 'Plasmodium knowlesi: reservoir hosts and tracking the emergence in humans and macaques' PLoS Pathogens, vol 7, no. 4, e1002015. DOI: 10.1371/journal.ppat.1002015
Arnold, IC, Zigova, Z, Holden, M, Lawley, TD, Rad, R, Dougan, G, Falkow, S, Bentley, SD & Mueller, A 2011, 'Comparative Whole Genome Sequence Analysis of the Carcinogenic Bacterial Model Pathogen Helicobacter felis' Genome Biology and Evolution, vol 3, pp. 302-308. DOI: 10.1093/gbe/evr022
Holt, DC, Holden, MTG, Tong, SYC, Castillo-Ramirez, S, Clarke, L, Quail, MA, Currie, BJ, Parkhill, J, Bentley, SD, Feil, EJ & Giffard, PM 2011, 'A Very Early-Branching Staphylococcus aureus Lineage Lacking the Carotenoid Pigment Staphyloxanthin' Genome Biology and Evolution, vol 3, pp. 881-895. DOI: 10.1093/gbe/evr078
Gillespie, SH & Singh, K 2011, Fluoroquinolones in the management of tuberculosis. in P Donald & P van Helden (eds), Anti-tuberculosis Chemotherapy. vol. 40, Progress in Respiratory Research , Karger, Basel, pp. 51-60.
Menzies, S, Rahman, N, Wrightson, J, Davies, H, Shorten, R, Gillespie, SH, Davies, C, Maskell, N, Jeffrey, A, Lee, G & Davies, R 2011, 'Blood culture bottle culture of pleural fluid in pleural infection' Thorax, vol 66, no. 8, pp. 658-662. DOI: 10.1136/thx.2010.157842
Dowling, AJ, Wilkinson, PA, Holden, MTG, Quail, MA, Bentley, SD, Reger, J, Waterfield, NR, Titball, RW & Ffrench-Constant, RH 2010, 'Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen Burkholderia pseudomallei K96243' PLoS One, vol 5, no. 12, 15693. DOI: 10.1371/journal.pone.0015693
Priestnall, SL, Erles, K, Brooks, HW, Cardwell, JM, Waller, AS, Paillot, R, Robinson, C, Darby, AC, Holden, MTG & Schoeniger, S 2010, 'Characterization of Pneumonia Due to Streptococcus equi subsp. zooepidemicus in Dogs' Clinical and Vaccine Immunology, vol 17, no. 11, pp. 1790-1796. DOI: 10.1128/CVI.00188-10
Paillot, R, Darby, AC, Robinson, C, Wright, NL, Steward, KF, Anderson, E, Webb, K, Holden, MTG, Efstratiou, A, Broughton, K, Jolley, KA, Priestnall, SL, Campi, MCM, Hughes, MA, Radford, A, Erles, K & Waller, AS 2010, 'Identification of Three Novel Superantigen-Encoding Genes in Streptococcus equi subsp zooepidemicus, szeF, szeN, and szeP' Infection and Immunity, vol 78, no. 11, pp. 4817-4827. DOI: 10.1128/IAI.00751-10
Cox-Singh, J & Cox Singh, J 2010, 'Malaria: what can apes teach humans?' Future Microbiology, vol 5, no. 8, pp. 1157-1160. DOI: 10.2217/FMB.10.86
Sonthayanon, P, Peacock, SJ, Chierakul, W, Wuthiekanun, V, Blacksell, SD, Holden, MTG, Bentley, SD, Feil, EJ, Day, NPJ & Holden, M 2010, 'High Rates of Homologous Recombination in the Mite Endosymbiont and Opportunistic Human Pathogen Orientia tsutsugamushi' PLoS Neglected Tropical Diseases, vol 4, no. 7, 752. DOI: 10.1371/journal.pntd.0000752
Ahouidi, AD, Bei, AK, Neafsey, DE, Sarr, O, Volkman, S, Milner, D, Cox-Singh, J, Ferreira, MU, Ndir, O, Premji, Z, Mboup, S, Duraisingh, MT & Cox Singh, J 2010, 'Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens' Infection Genetics and Evolution, vol 10, no. 2, pp. 200-206. DOI: 10.1016/j.meegid.2009.11.008
Holden, MTG, Lindsay, JA, Corton, C, Quail, MA, Cockfield, JD, Pathak, S, Batra, R, Parkhill, J, Bentley, SD & Edgeworth, JD 2010, 'Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)' Journal of Bacteriology, vol 192, no. 3, pp. 888-892. DOI: 10.1128/JB.01255-09
Harris, SR, Feil, EJ, Holden, MTG, Quail, MA, Nickerson, EK, Chantratita, N, Gardete, S, Tavares, A, Day, N, Lindsay, JA, Edgeworth, JD, de Lencastre, H, Parkhill, J, Peacock, SJ & Bentley, SD 2010, 'Evolution of MRSA During Hospital Transmission and Intercontinental Spread' Science, vol 327, no. 5964, pp. 469-474. DOI: 10.1126/science.1182395
Cox Singh, J, Hiu, J, Lucas, SB, Divis, PC, Zulkarnaen, M, Chandran, P, Wong, KT, Adem, P, Zaki, SR, Singh, B & Krishna, S 2010, 'Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report' Malaria Journal, vol 9, 10. DOI: 10.1186/1475-2875-9-10
Gillespie, SH, Pope, CF & McHugh, TD 2010, Methods to determine fitness in bacteria. in Methods in Molecular Biology. 2 edn, vol. 642, Springer Science and Business Media, pp. 113-121.
Perrin, FMR, Breen, RAM, McHugh, TD, Gillespie, SH & Lipman, MCI 2009, 'Are patients on treatment for pulmonary TB who stop expectorating sputum genuinely culture negative?' Thorax, vol 64, no. 11, pp. 1009-1010. DOI: 10.1136/thx.2009.115915
Daneshvar, C, Davis, TME, Cox Singh, J, Rafa'ee, MZ, Zakaria, SK, Divis, PCS & Singh, B 2009, 'Clinical and Laboratory Features of Human Plasmodium knowlesi Infection' Clinical Infectious Diseases, vol 49, no. 6, pp. 852-860. DOI: 10.1086/605439
Holden, MTG, Hauser, H, Sanders, M, Ngo, TH, Cherevach, I, Cronin, A, Goodhead, I, Mungall, K, Quail, MA, Price, C, Rabbinowitsch, E, Sharp, S, Croucher, NJ, Chieu, TB, Mai, NTH, Diep, TS, Chinh, NT, Kehoe, M, Leigh, JA, Ward, PN, Dowson, CG, Whatmore, AM, Chanter, N, Iversen, P, Gottschalk, M, Slater, JD, Smith, HE, Spratt, BG, Xu, J, Ye, C, Bentley, S, Barrell, BG, Schultsz, C, Maskell, DJ & Parkhill, J 2009, 'Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen streptococcus suis' PLoS One, vol 4, no. 7, e6072. DOI: 10.1371/journal.pone.0006072
Jenkins, C, Bacon, J, Allnutt, J, Hatch, KA, Bose, A, O'Sullivan, DM, Arnold, C, Gillespie, SH & McHugh, TD 2009, 'Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH' Journal of Antimicrobial Chemotherapy, vol 63, no. 6, pp. 1118-1120. DOI: 10.1093/jac/dkp125
Al-Balas, Q, Anthony, NG, Al-Jaidi, B, Alnimr, A, Abbott, G, Brown, AK, Taylor, RC, Besra, GS, McHugh, TD, Gillespie, SH, Johnston, BF, Mackay, SP & Coxon, GD 2009, 'Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH' PLoS One, vol 4, no. 5, pp. e5617. DOI: 10.1371/journal.pone.0005617
Holden, MTG, Seth-Smith, HMB, Crossman, LC, Sebaihia, M, Bentley, SD, Cerdeno-Tarraga, AM, Thomson, NR, Bason, N, Quail, MA, Sharp, S, Cherevach, I, Churcher, C, Goodhead, I, Hauser, H, Holroyd, N, Mungall, K, Scott, P, Walker, D, White, B, Rose, H, Iversen, P, Mil-Homens, D, Rocha, EPC, Fialho, AM, Baldwin, A, Dowson, C, Barrell, BG, Govan, JR, Vandamme, P, Hart, CA, Mahenthiralingam, E & Parkhill, J 2009, 'The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients (vol 191, pg 261, 2009)' Journal of Bacteriology, vol 191, no. 8, pp. 2907-2907. DOI: 10.1128/JB.00168-09
Amin, AK, Manuel, RJ, Ison, CA, Woodham, R, Shemko, M, Maguire, H, Giraudon, I, Forde, J & Gillespie, SH 2009, 'Audit of laboratory diagnostic methods for syphilis in England and Wales' Sexually Transmitted Infections, vol 85, no. 2, pp. 88-91. DOI: 10.1136/sti.2008.033159
Holden, MTG, Heather, Z, Paillot, R, Steward, KF, Webb, K, Ainslie, F, Jourdan, T, Bason, NC, Holroyd, NE, Mungall, K, Quail, MA, Sanders, M, Simmonds, M, Willey, D, Brooks, K, Aanensen, DM, Spratt, BG, Jolley, KA, Maiden, MCJ, Kehoe, M, Chanter, N, Bentley, SD, Robinson, C, Maskell, DJ, Parkhill, J & Waller, AS 2009, 'Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens' PLoS Pathogens, vol 5, no. 3, e1000346. DOI: 10.1371/journal.ppat.1000346
Myers, WP, Myers, AP, Cox Singh, J, Lau, HC, Mokuai, B & Malley, R 2009, 'Micro-geographic risk factors for malarial infection' Malaria Journal, vol 8, 27. DOI: 10.1186/1475-2875-8-27
Ward, PN, Holden, MTG, Leigh, JA, Lennard, N, Bignell, A, Barron, A, Clark, L, Quail, MA, Woodward, J, Barrell, BG, Egan, SA, Field, TR, Maskell, D, Kehoe, M, Dowson, CG, Chanter, N, Whatmore, AM, Bentley, SD & Parkhill, J 2009, 'Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis' BMC Genomics, vol 10, 54. DOI: 10.1186/1471-2164-10-54
Holden, MTG, Seth-Smith, HMB, Crossman, LC, Sebaihia, M, Bentley, SD, Cerdeno-Tarraga, AM, Thomson, NR, Bason, N, Quail, MA, Sharp, S, Cherevach, I, Churcher, C, Goodhead, I, Hauser, H, Holroyd, N, Mungall, K, Scott, P, Walker, D, White, B, Rose, H, Iversen, P, Mil-Homens, D, Rocha, EPC, Fialho, AM, Baldwin, A, Dowson, C, Barrell, BG, Govan, JR, Vandamme, P, Hart, CA, Mahenthiralingam, E & Parkhill, J 2009, 'The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients' Journal of Bacteriology, vol 191, no. 1, pp. 261-277. DOI: 10.1128/JB.01230-08
Gillespie, SH & Bamford, K 2009, Medical Microbiology and Infection at a Glance. Third Edition edn, Peneerbit erlangga.
Hjerde, E, Lorentzen, MS, Holden, MTG, Seeger, K, Paulsen, S, Bason, N, Churcher, C, Harris, D, Norbertczak, H, Quail, MA, Sanders, S, Thurston, S, Parkhill, J, Willassen, NP & Thomson, NR 2008, 'The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay' BMC Genomics, vol 9, 616. DOI: 10.1186/1471-2164-9-616
Heather, Z, Holden, MTG, Steward, KF, Parkhill, J, Song, L, Challis, GL, Robinson, C, Davis-Poynter, N & Waller, AS 2008, 'A novel streptococcal integrative conjugative element involved in iron acquisition' Molecular Microbiology, vol 70, no. 5, pp. 1274-1292. DOI: 10.1111/j.1365-2958.2008.06481.x
Davies, AP, Dhillon, AP, Young, M, Henderson, B, McHugh, TD & Gillespie, SH 2008, 'Resuscitation-promoting factors are expressed in Mycobacterium tuberculosis-infected human tissue' Tuberculosis, vol 88, no. 5, pp. 462-468. DOI: 10.1016/j.tube.2008.01.007
Tumapa, S, Holden, MTG, Vesaratchavest, M, Wuthiekanun, V, Limmathurotsakul, D, Chierakul, W, Feil, EJ, Currie, BJ, Day, NPJ, Nierman, WC & Peacock, SJ 2008, 'Burkholderia pseudomallei genome plasticity associated with genomic island variation' BMC Genomics, vol 9, 190. DOI: 10.1186/1471-2164-9-190
Cox Singh, J, Davis, TME, Lee, K-S, Shamsul, SSG, Matusop, A, Ratnam, S, Rahman, HA, Conway, DJ & Singh, B 2008, 'Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening' Clinical Infectious Diseases, vol 46, no. 2, pp. 165-171. DOI: 10.1086/524888
Thomson, NR, Holden, MTG, Carder, C, Lennard, N, Lockey, SJ, Marsh, P, Skipp, P, O'Connor, CD, Goodhead, I, Norbertzcak, H, Harris, B, Ormond, D, Rance, R, Quail, MA, Parkhill, J, Stephens, RS & Clarke, IN 2008, 'Chlamydia trachomatis: Genome sequence analysis of lymphogranuloma venereum isolates' Genome Research, vol 18, no. 1, pp. 161-171. DOI: 10.1101/gr.7020108
Breen, RAM, Barry, SM, Smith, CJ, Shorten, RJ, Dilworth, JP, Cropley, I, McHugh, TD, Gillespie, SH, Janossy, G & Lipman, MCI 2008, 'Clinical application of a rapid lung-orientated immunoassay in individuals with possible tuberculosis' Thorax, vol 63, no. 1, pp. 67-71. DOI: 10.1136/thx.2007.078857
O'Sullivan, DM, Sander, C, Shorten, RJ, Gillespie, SH, Hill, AVS, McHugh, TD, McShane, H & Tchilian, EZ 2007, 'Evaluation of liquid culture for quantitation of Mycobacterium tuberculosis in murine models' Vaccine, vol 25, no. 49, pp. 8203-8205. DOI: 10.1016/j.vaccine.2007.09.065
Sebaihia, M, Peck, MW, Minton, NP, Thomson, NR, Holden, MTG, Mitchell, WJ, Carter, AT, Bentley, SD, Mason, DR, Crossman, L, Paul, CJ, Ivens, A, Wells-Bennik, MHJ, Davis, IJ, Cerdeno-Tarraga, AM, Churcher, C, Quail, MA, Chillingworth, T, Feltwell, T, Fraser, A, Goodhead, I, Hance, Z, Jagels, K, Larke, N, Maddison, M, Moule, S, Mungall, K, Norbertczak, H, Rabbinowitsch, E, Sanders, M, Simmonds, M, White, B, Whithead, S & Parkhill, J 2007, 'Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes' Genome Research, vol 17, no. 7, pp. 1082-1092. DOI: 10.1101/gr.6282807
Tiyawisutsri, R, Holden, MTG, Tumapa, S, Rengpipat, S, Clarke, SR, Foster, SJ, Nierman, WC, Day, NPJ & Peacock, SJ 2007, 'Burkholderia Hep_Hap autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis' BMC Microbiology, vol 7, 19. DOI: 10.1186/1471-2180-7-19
Holden, MTG, Scott, A, Cherevach, I, Chillingworth, T, Churcher, C, Cronin, A, Dowd, L, Feltwell, T, Hamlin, N, Holroyd, S, Jagels, K, Moule, S, Mungall, K, Quail, MA, Price, C, Rabbinowitsch, E, Sharp, S, Skelton, J, Whitehead, S, Barrell, BG, Kehoe, M & Parkhill, J 2007, 'Complete genome of acute rheumatic fever-associated serotype M5 Streptococcus pyogenes strain Manfredo' Journal of Bacteriology, vol 189, no. 4, pp. 1473-1477. DOI: 10.1128/JB.01227-06
Mulenga, V, Ford, D, Walker, AS, Mwenya, D, Mwansa, J, Sinyinza, F, Lishimpi, K, Nunn, A, Gillespie, S, Zumla, A, Chintu, C, Gibb, DM & CHAP Trial Team 2007, 'Effect of cotrimoxazole on causes of death, hospital admissions and antibiotic use in HIV-infected children' AIDS, vol 21, no. 1, pp. 77-84.
Thomson, NR, Howard, S, Wren, BW, Holden, MTG, Crossman, L, Challis, GL, Churcher, C, Mungall, K, Brooks, K, Chillingworth, T, Feltwell, T, Abdellah, Z, Hauser, H, Jagels, K, Maddison, M, Moule, S, Sanders, M, Whitehead, S, Quail, MA, Dougan, G, Parkhill, J & Prentice, MB 2006, 'The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081' PLoS Genetics, vol 2, no. 12, 206, pp. 2039-2051. DOI: 10.1371/journal.pgen.0020206
Vesaratchavest, M, Tumapa, S, Day, NPJ, Wuthiekanun, V, Chierakul, W, Holden, MTG, White, NJ, Currie, BJ, Spratt, BG, Feil, EJ & Peacock, SJ 2006, 'Nonrandom distribution of Burkholderia pseudomallei clones in relation to geographical location and virulence' Journal of Clinical Microbiology, vol 44, no. 7, pp. 2553-2557. DOI: 10.1128/JCM.00629-06
Sebaihia, M, Wren, BW, Mullany, P, Fairweather, NF, Minton, N, Stabler, R, Thomson, NR, Roberts, AP, Cerdeno-Tarrraga, AM, Wang, H, Holden, MTG, Wright, A, Churcher, C, Quail, MA, Baker, S, Bason, N, Brooks, K, Chillingworth, T, Cronin, A, Davis, P, Dowd, L, Fraser, A, Feltwell, T, Hance, Z, Holroyd, S, Jagels, K, Moule, S, Mungall, K, Price, C, Rabbinowitsch, E, Sharp, S, Simmonds, M, Stevens, K, Unwin, L, Whithead, S, Dupuy, B, Dougan, G, Barrell, B & Parkhill, J 2006, 'The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome' Nature Genetics, vol 38, no. 7, pp. 779-786. DOI: 10.1038/ng1830
Rocha, EPC, Smith, JM, Hurst, LD, Holden, MTG, Cooper, JE, Smith, NH & Feil, EJ 2006, 'Comparisons of dN/dS are time dependent for closely related bacterial genomes' Journal of Theoretical Biology, vol 239, no. 2, pp. 226-235. DOI: 10.1016/j.jtbi.2005.08.037
Allen, MJ, Schroeder, DC, Holden, MTG & Wilson, WH 2006, 'Evolutionary history of the Coccolithoviridae' Molecular Biology and Evolution, vol 23, no. 1, pp. 86-92. DOI: 10.1093/molbev/msj010
Creer, DD, Dilworth, JP, Gillespie, SH, Johnston, AR, Johnston, SL, Ling, C, Patel, S, Sanderson, G, Wallace, PG & McHugh, TD 2006, 'Aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (LRTI) in primary care' Thorax, vol 61, no. 1, pp. 75-79. DOI: 10.1136/thx.2004.027441
Wilson, WH, Schroeder, DC, Allen, MJ, Holden, MTG, Parkhill, J, Barrell, BG, Churcher, C, Harnlin, N, Mungall, K, Norbertczak, H, Quail, MA, Price, C, Rabbinowitsch, E, Walker, D, Craigon, M, Roy, D & Ghazal, P 2005, 'Complete genome sequence and lytic phase transcription profile of a Coccolithovirus' Science, vol 309, no. 5737, pp. 1090-1092. DOI: 10.1126/science.1113109
Perrin, FMR, Breen, RAM, Lipman, MCI, Shorten, RJ, Gillespie, SH & McHugh, TD 2005, 'Is there a relationship between Mycobacterium tuberculosis strain type and TB paradoxical reaction?' Thorax, vol 60, no. 8, pp. 706-707. DOI: 10.1136/thx.2005.044321
Jenkins, C, Claxton, AP, Shorten, RJ, McHugh, TD & Gillespie, SH 2005, 'Rifampicin resistance in tuberculosis outbreak, London, England' Emerging Infectious Diseases, vol 11, no. 6, pp. 931-934.
Dale, JW, Bothamley, GH, Drobniewski, F, Gillespie, SH, McHugh, TD & Pitman, R 2005, 'Origins and properties of Mycobacterium tuberculosis isolates in London' Journal of Medical Microbiology, vol 54, no. 6, pp. 575-582. DOI: 10.1099/jmm.0.45959-0
Anthony, TG, Conway, DJ, Cox-Singh, J, Matusop, A, Ratnam, S, Shamsul, S, Singh, B & Cox Singh, J 2005, 'Fragmented population structure of Plasmodium falciparum in a region of declining endemicity' Journal of Infectious Diseases, vol 191, no. 9, pp. 1558-1564.