INFECTION AND GLOBAL HEALTH RESEARCH DIVISION

Research at the University of St Andrews School of Medicine

Publications

Infection group recent publications

250 (of 471 /dk/atira/pure/researchoutput/status/published available) for Infection Group (source: University of St Andrews PURE)
Please click title of any item for full details

An international perspective on hospitalized patients with viral community-acquired pneumonia Dejan Radovanovic, Giovanni Sotgiu, Mateja Jankovic, Padukudru Anand Mahesh, Pedro Jorge Marcos, Mohamed I Abdalla, Marta Francesca Di Pasquale, Andrea Gramegna, Silvia Terraneo, Francesco Blasi, Pierachille Santus, Stefano Aliberti, Luis F Reyes, Marcos I Restrepo, Devesh Janardan Dhasmana,
European Journal of Internal Medicine 2019 vol. 60 pp. 54-70
Antimicrobial resistance in atopic dermatitis Matthew Holden, A.D. Irvine
Annals of Allergy Asthma & Immunology 2019 vol. 122 pp. 236-240
Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics Mark R Davies, Liam McIntyre, Ankur Mutreja, Jake A Lacey, John A Lees, Rebecca J Towers, Sebastián Duchêne, Pierre R Smeesters, Hannah R Frost, David J. Price, Matthew Holden, Sophia David, Philip M Giffard, Kate A Worthing, Anna C Seale, James A Berkley, Simon R Harris, Tania Rivera-Hernandez, Olga Berking, Amanda J Cork, Rosângela S L A Torres, Trevor Lithgow, Richard A Strugnell, Rene Bergmann, Patric Nitsche-Schmitz, Gusharan S Chhatwal, Stephen D Bentley, John D Fraser, Nicole J Moreland, Jonathan R Carapetis, Andrew C Steer, Julian Parkhill, Allan Saul, Deborah A Williamson, Bart J Currie, Steven Y C Tong, Gordon Dougan, Mark J Walker
Nature Genetics 2019 vol. 51 pp. 1035-1043
Can phenotypic data complement our understanding of antimycobacterial effects for drug combinations? Frank Kloprogge, Andrew Copas, Stephen Henry Gillespie, Oscar Della Pasqua
Journal of Antimicrobial Chemotherapy 2019 vol. 74 pp. 3530–3536
Chlorhexidine and octenidine use, qac genes carriage, and reduced antiseptic susceptibility in methicillin-resistant Staphylococcus aureus isolates from a healthcare network Htet Lin Htun, Pei Yun Hon, Matthew Holden, Brenda Ang, Angela Chow
Clinical Microbiology and Infection 2019 vol. 25 pp. 1154.e1-1154.e7
Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei Claire Chewapreecha, Alison E. Mather, Simon R. Harris, Martin Hunt, Matthew Holden, Chutima Chaichana, Vanaporn Wuthiekanun, Gordon Dougan, Nicholas P. J. Day, Direk Limmathurotsakul, Julian Parkhill, Sharon J. Peacock
Communications Biology 2019 vol. 2
Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus Ewan M. Harrison, Xiaoliang Ba, Francesc Coll, Beth Blane, Olivier Restif, Henry Carvell, C.U. Köser, Dorota Jamrozy, S. Reuter, Andrew Lovering, Nicholas Gleadall, Katherine L. Bellis, Anne Catrin Uhlemann, Franklin D. Lowy, Ruth C. Massey, Inês R. Grilo, Rita Sobral, Jesper Larsen, Anders Rhod Larsen, Carina Vingsbo Lundberg, J. Parkhill, Gavin K. Paterson, Matthew Holden, Sharon J. Peacock, Mark A. Holmes
Nature Microbiology 2019
Heat-inactivation renders sputum safe and preserves Mycobacterium tuberculosis RNA for downstream molecular tests Wilber Sabiiti, Khalide Azam, Ezembro Esmeraldo, Nilesh Bhatt, Andrea Rachow, Stephen Henry Gillespie
Journal of Clinical Microbiology 2019 vol. 57
Mimicking in-vivo exposures to drug combinations in-vitro Frank Kloprogge, Karin Kipper, Stephen Henry Gillespie, Oscar Della Pasqua
Scientific Reports 2019 vol. 9
Molecular bacterial load assay (MBLA) concurs with culture on the NaOH-induced Mycobacterium tuberculosis loss of viability Wilber Sabiiti, Issa Sabi, Joseph John, Emanuel Sichone, Nyanda E. Ntinginya, Stephen Henry Gillespie
Journal of Clinical Microbiology 2019 vol. 57
Molecular epidemiology and expression of capsular polysaccharides in Staphylococcus aureus clinical isolates in the United States Naglaa Mohamed, Yekaterina Timofeyeva, Dorota Jamrozy, Eduardo Rojas, Li Hao, Natalie C. Silmon de Monerri, Julio Hawkins, Guy Singh, Bing Cai, Paul Liberator, Shite Sebastian, Robert G. K. Donald, Ingrid L. Scully, C. Hal Jones, C. Buddy Creech, Isaac Thomsen, Julian Parkhill, Sharon J. Peacock, Kathrin U. Jansen, Matthew Holden, Annaliesa S. Anderson
PLoS ONE 2019 vol. 14
The Emergence of Successful Streptococcus pyogenes Lineages through Convergent Pathways of Capsule Loss and Recombination Directing High Toxin Expression Claire E Turner, Matthew Holden, Beth Blane, Carolyne Horner, Sharon J Peacock, Shiranee Sriskandan
mBio 2019 vol. 10
Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status Conor Tweed, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Lerato Mohapi, Michael E. Murphy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha P. Singh, Melvin Spigelman, Stephen Henry Gillespie
BMC Pulmonary Medicine 2019 vol. 19
Plasmodium knowlesi Janet Cox-Singh
Parasitology 2018 vol. 145 pp. 1-5
Pseudomonas aeruginosa intensive care unit outbreak Katarina Oravcova, Miguel Pinheiro, Matthew Holden, Gabby Phillips, Jane F. Turton, Stephen Henry Gillespie
Journal of Hospital Infection 2018 vol. 98 pp. 282-288
A population pharmacokinetic model incorporating saturable pharmacokinetics and autoinduction for high rifampicin doses Robin J Svensson, Rob E Aarnoutse, Andreas H Diacon, Rodney Dawson, Stephen Henry Gillespie, Martin J Boeree, Ulrika S. H. Simonsson
Clinical Pharmacology & Therapeutics 2018 vol. 103 pp. 674-683
A spatially heterogeneous network-based metapopulation software model applied to the simulation of a pulmonary tuberculosis infection Ruth Bowness, Simon Andrew Dobson, Stephen Henry Gillespie
Applied Network Science 2018 vol. 3
An outbreak of Streptococcus pyogenes in a mental health facility Sarah M Bergin, Balamurugan Periaswamy, Timothy Barkham, Hong Choon Chua, Yee Ming Mok, Daniel Shuen Sheng Fung, Alex Hsin Chuan Su, Yen Ling Lee, Ming Lai Ivan Chua, Poh Yong Ng, Wei Jia Wendy Soon, Collins Wenhan Chu, Siyun Lucinda Tan, Mary Meehan, Brenda Sze Peng Ang, Yee Sin Leo, Matthew Holden, Partha De, Li Yang Hsu, Swaine L Chen, Paola Florez de Sessions, Kalisvar Marimuthu
Infection Control and Hospital Epidemiology 2018 vol. 39 pp. 852-860
Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia Marcos I Restrepo, Bettina L Babu, Luis F Reyes, James D Chalmers, Nilam J Soni, Oriol Sibila, Paola Faverio, Catia Cilloniz, William Rodriguez-Cintron, Stefano Aliberti, Devesh Janardan Dhasmana
European Respiratory Journal 2018 vol. 52
Comparative sequence analysis of the capsular polysaccharide loci of Actinobacillus pleuropneumoniae serovars 1-18, and development of two multiplex PCRs for comprehensive capsule typing Janine T Bossé, Yanwen Li, Roberto Fernandez Crespo, Sonia Lacouture, Marcelo Gottschalk, Rita Sárközi, László Fodor, Maria Casas Amoribieta, Øystein Angen, Katerina Nedbalcova, Matthew Holden, Duncan J Maskell, Alexander W Tucker, Brendan W Wren, Andrew N Rycroft, Paul R Langford,
Veterinary Microbiology 2018 vol. 220 pp. 83-89
Comparison of different treatments for isoniazid-resistant tuberculosis Federica Fregonese, Shama D Ahuja, Onno W Akkerman, Denise Arakaki-Sanchez, Irene Ayakaka, Parvaneh Baghaei, Didi Bang, Mayara Bastos, Andrea Benedetti, Maryline Bonnet, Adithya Cattamanchi, Peter Cegielski, Jung-Yien Chien, Helen Cox, Martin Dedicoat, Connie Erkens, Patricio Escalante, Dennis Falzon, Anthony J Garcia-Prats, Medea Gegia, Stephen Henry Gillespie, Judith R Glynn, Stefan Goldberg, David Griffith, Karen R Jacobson, James C Johnston, Edward C Jones-López, Awal Khan, Won-Jung Koh, Afranio Kritski, Zhi Yi Lan, Jae Ho Lee, Pei Zhi Li, Ethel L Maciel, Rafael Mello Galliez, Corinne S C Merle, Melinda Munang, Gopalan Narendran, Viet Nhung Nguyen, Andrew Nunn, Akihiro Ohkado, Jong Sun Park, Patrick P J Phillips, Chinnaiyan Ponnuraja, Randall Reves, Kamila Romanowski, Kwonjune Seung, H Simon Schaaf, Alena Skrahina, Dick van Soolingen, Payam Tabarsi, Anete Trajman, Lisa Trieu, Velayutham V Banurekha, Piret Viiklepp, Jann-Yuan Wang, Takashi Yoshiyama, Dick Menzies
The Lancet Respiratory Medicine 2018 vol. 6 pp. 265-275
Detecting phenotypically resistant Mycobacterium tuberculosis using wavelength modulated Raman spectroscopy Mingzhou Chen, Simon O Clark, Ann Williams, Kishan Dholakia, Stephen Henry Gillespie
2018 pp. 41-50
Distinct evolutionary patterns of Neisseria meningitidis serogroup B disease outbreaks at two universities in the USA Li Hao, Matthew Holden, Xin Wang, Lubomira Andrew, Sabine Wellnitz, Fang Hu, Melissa Whaley, Scott Sammons, Kristen Knipe, Mike Frace, Lucy A McNamara, Paul Liberator, Annaliesa S Anderson
Microbial Genomics 2018 vol. 4
Gender differences in tuberculosis treatment outcomes M. E. Murphy, G. H. Wills, S. Murthy, C. Louw, A. L. C. Bateson, R. D. Hunt, T. D. McHugh, A. J. Nunn, S. K. Meredith, C. M. Mendel, M. Spigelman, A. M. Crook, Stephen Henry Gillespie,
BMC Medicine 2018 vol. 16
Genetic analysis of invasive Escherichia coli in Scotland reveals determinants of healthcare-associated versus community-acquired infections Cosmika Goswami, Stephen Fox, Matthew Holden, Martin Connor, Alistair Leanord, Thomas J. Evans
Microbial Genomics 2018 vol. 4
Global scale dissemination of ST93 Sebastiaan J. van Hal, Eike J. Steinig, Patiyan Andersson, Matthew Holden, Simon R. Harris, Graeme R. Nimmo, Deborah A. Williamson, Helen Heffernan, S. R. Ritchie, Angela M. Kearns, Matthew J. Ellington, Elizabeth Dickson, Herminia de Lencastre, Geoffrey W. Coombs, Stephen D. Bentley, Julian Parkhill, Deborah C. Holt, Phillip M. Giffard, Steven Y. C. Tong
Frontiers in Microbiology 2018 vol. 9
Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study Conor Tweed, Genevieve Helen Wills, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Cheryl E. Louw, Timothy D. McHugh, Carl Mendel, Sarah Meredith, Lerato Mohapi, Michael E. Murphy, Stephen Murray, Sara Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha Singh, M. Spigelman, Stephen Henry Gillespie
BMC Medicine 2018 vol. 16
Mobile-genetic-element-encoded hypertolerance to copper protects Staphylococcus aureus from killing by host phagocytes Marta Zapotoczna, Gustavo P Riboldi, Ahmed M Moustafa, Elizabeth Dickson, Apurva Narechania, Julie A Morrissey, Paul J Planet, Matthew Holden, Kevin J Waldron, Joan A Geoghegan
mBio 2018 vol. 9
Modelling the effects of bacterial cell state and spatial location on tuberculosis treatment Ruth Bowness, Mark Andrew Joseph Chaplain, Gibin G. Powathil, Stephen Henry Gillespie
Journal of Theoretical Biology 2018 vol. 446 pp. 87-100
Moxifloxacin replacement in contemporary tuberculosis drug regimens is ineffective against persistent Mycobacterium tuberculosis Yingjun Liu, Henry Pertinez, Geraint R Davies, Stephen Henry Gillespie, Anthony R Coates, Yanmin Hu
Antimicrobial Agents and Chemotherapy 2018 vol. 62
Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility Aishwarya Krishna, Matthew Holden, Sharon J Peacock, Andrew M Edwards, Sivaramesh Wigneshweraraj
Microbiology 2018 vol. 164 pp. 1189-1195
OMNIgene.SPUTUM suppresses contaminants whilst maintaining Mycobacterium tuberculosis viability and obviates cold-chain transport Khalide Azam, Nureisha Cadir, Carla Madeira, Stephen Henry Gillespie, Wilber Sabiiti
ERJ Open Research 2018 vol. 4
Phenotypic changes on Mycobacterium tuberculosis-specific CD4 T cells as surrogate markers for tuberculosis treatment efficacy Mohamed I. M. Ahmed, Nyanda E. Ntinginya, Gibson Kibiki, Hadija Semvua, Stellah Mpagama, Charles Mtabho, Elmar Saathoff, Kathrin Held, Rebecca Loose, Inge Kroidl, Mkunde Chachage, Ulrich von Both, Antelmo Haule, Anna-Maria Mekota, Martin J. Boeree, Stephen Henry Gillespie, Michael Hoelscher, Norbert Heinrich, Christof Geldmacher,
Frontiers in Immunology 2018 vol. 9
Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis S. E. Murthy, F. Chatterjee, A. Crook, R. Dawson, C. Mendel, M. E. Murphy, S. R. Murray, A. J. Nunn, P. P. J. Phillips, Kasha P. Singh, T. D. McHugh, Stephen Henry Gillespie,
BMC Medicine 2018 vol. 16
Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis Janine T. Bossé, Yanwen Li, Rita Sárközi, László Fodor, Sonia Lacouture, Marcelo Gottschalk, Maria Casas Amoribieta, Øystein Angen, Katerina Nedbalcova, Matthew Holden, Duncan J. Maskell, Alexander W. Tucker, Brendan W. Wren, Andrew N. Rycroft, Paul R. Langford,
Veterinary Microbiology 2018 vol. 217 pp. 1-6
The microevolution and epidemiology of Staphylococcus aureus colonization during atopic eczema disease flare Kerry Andrea Pettigrew, Katarina Oravcova, June Gardner, R. M. Ross Hearn, Debbie Rice, Alison E Mather, Julian Parkhill, Sara J. Brown, Charlotte M. Proby, Matthew Holden
Journal of Investigative Dermatology 2018 vol. 138 pp. 336-343
The potential for treatment shortening with higher rifampicin doses Elin M Svensson, Robin J Svensson, Lindsey H M Te Brake, Martin J Boeree, Norbert Heinrich, Sarah Konsten, Gavin Churchyard, Rodney Dawson, Andreas H Diacon, Gibson S Kibiki, Lilian T Minja, Nyanda E Ntingiya, Ian Sanne, Stephen Henry Gillespie, Michael Hoelscher, Patrick P J Phillips, Ulrika S H Simonsson, Rob Aarnoutse
Clinical Infectious Diseases 2018 vol. 67 pp. 34-41
The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from Atopic Dermatitis patients M. A. McAleer, D. Bennett, O. M. Fleury, Kerry Andrea Pettigrew, Katarina Oravcova, J. Parkhill, C. M. Proby, R. S. Dawe, J. A. Geoghegan, A. D. Irvine, Matthew Holden
British Journal of Dermatology 2018 vol. 179 pp. 951-958
Toxicity associated with tuberculosis chemotherapy in the REMoxTB study Conor Tweed, Angela M. Crook, Evans I. Amukoye, Rodney Dawson, Andreas H. Diacon, Madeline Hanekom, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Michael E. Murphy, Saraswathi E. Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha P. Singh, Melvin Spigelman, Genevieve H. Wills, Stephen Henry Gillespie
BMC Infectious Diseases 2018 vol. 18
2015 epidemic of severe Streptococcus agalactiae sequence type 283 infections in Singapore associated with the consumption of raw freshwater fish Shirin Kalimuddin, Swaine L Chen, Cindy T K Lim, Tse Hsien Koh, Thean-Yen Tan, Michelle Kam, Christopher W Wong, Kurosh S Mehershahi, Man Ling Chau, Lee Ching Ng, Wen Ying Tang, Hishamuddin Badaruddin, Jeanette Teo, Anucha Apisarnthanarak, Nuntra Suwantarat, Margaret Ip, Matthew Holden, Li-Yang Hsu, Timothy Barkham,
Clinical Infectious Diseases 2017 vol. 64 pp. S145-S152
Burkholderia cepacia complex and limited cutaneous vasculitis in patients with cystic fibrosis Muttardi Kayria, Orchard Chris, Devesh Janardan Dhasmana, Morar Nilesh, Margaret E Hodson, Gyi Khin, Bilton Diana, Nicholas J Simmonds
JRSM Open 2017 vol. 8 pp. 1-4
A comparison of liquid and solid culture for determining relapse and durable cure in phase III TB trials for new regimens Patrick P. J. Phillips, Carl M. Mendel, Andrew J. Nunn, Timothy D. McHugh, Angela M. Crook, Robert Hunt, Anna Bateson, Stephen Henry Gillespie
BMC Medicine 2017 vol. 15
Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis Simon L F Walsh, Toby M Maher, Martin Kolb, Venerino Poletti, Richard Nusser, Luca Richeldi, Carlo Vancheri, Margaret L Wilsher, Katerina M Antoniou, Jüergen Behr, Elisabeth Bendstrup, Kevin Brown, Lucio Calandriello, Tamera J Corte, Vincent Cottin, Bruno Crestani, Kevin Flaherty, Ian Glaspole, Jan Grutters, Yoshikazu Inoue, Maria Kokosi, Yasuhiro Kondoh, Vasileios Kouranos, Michael Kreuter, Kerri Johannson, Eoin Judge, Brett Ley, George Margaritopoulos, Fernando J Martinez, Maria Molina-Molina, António Morais, Hilario Nunes, Ganesh Raghu, Christopher J Ryerson, Moises Selman, Paolo Spagnolo, Hiroyuki Taniguchi, Sara Tomassetti, Dominique Valeyre, Marlies Wijsenbeek, Wim Wuyts, David Hansell, Athol Wells, Devesh Janardan Dhasmana
European Respiratory Journal 2017 vol. 50
Diversity of Streptococcus equi subsp. zooepidemicus strains isolated from the Spanish sheep and goat population and the identification, function and prevalence of a novel arbutin utilisation system Karen F Steward, Carl Robinson, Matthew Holden, Simon R Harris, Ana Fernández Ros, Gema Chacón Pérez, Rafael Baselga, Andrew S Waller
Veterinary Microbiology 2017 vol. 207 pp. 231-238
Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus Baharak Afshar, Claire E Turner, Theresa Lamagni, Ken Smith, Ali Al-Shahib, Anthony Underwood, Matthew Holden, Androulla Efstratiou, Shiranee Sriskandan
Virulence 2017 vol. 8 pp. 1390-1400
Functional analysis of the EsaB component of the Staphylococcus aureus Type VII secretion system M Guillermina Casabona, Grant Buchanan, Martin Zoltner, Matthew Holden, Tracy Palmer
Microbiology 2017 vol. 163 pp. 1851-1863
Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases Sigríður Björnsdóttir, Simon R Harris, Vilhjálmur Svansson, Eggert Gunnarsson, Ólöf G Sigurðardóttir, Kristina Gammeljord, Karen F Steward, J Richard Newton, Carl Robinson, Amelia R L Charbonneau, Julian Parkhill, Matthew Holden, Andrew S Waller
mBio 2017 vol. 8
Genomic investigation unmasks evidence of transmission across mycobacterium abscessus cystic fibrosis patients Clare Peters, Devesh Janardan Dhasmana, Kerry Andrea Pettigrew, Ramon Fallon, A-l Seagar, Derek James Sloan, If Laurenson, Matthew Holden, Stephen Henry Gillespie
Thorax 2017 vol. 72 pp. A56-A56
Global and regional dissemination and evolution of Burkholderia pseudomallei Claire Chewapreecha, Matthew Holden, Minna Vehkala, Niko Välimäki, Zhirong Yang, Simon R Harris, Alison E Mather, Apichai Tuanyok, Birgit De Smet, Simon Le Hello, Chantal Bizet, Mark Mayo, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Rattanaphone Phetsouvanh, Brian G Spratt, Jukka Corander, Paul Keim, Gordon Dougan, David A B Dance, Bart J Currie, Julian Parkhill, Sharon J. Peacock
Nature Microbiology 2017 vol. 2
Haem-iron plays a key role in the regulation of the Ess/type VII secretion system of Staphylococcus aureus RN6390 M Guillermina Casabona, Holger Kneuper, Martin Zoltner, Erik Hjerde, Matthew Holden, Tracy Palmer
Microbiology 2017 vol. 163 pp. 1839-1850
High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis Martin J Boeree, Norbert Heinrich, Rob Aarnoutse, Andreas H Diacon, Rodney Dawson, Sunita Rehal, Gibson S Kibiki, Gavin Churchyard, Ian Sanne, Nyanda E Ntinginya, Lilian T Minja, Robert D Hunt, Salome Charalambous, Madeleine Hanekom, Hadija H Semvua, Stellah G Mpagama, Christina Manyama, Klaus Reither, Robert S Wallis, Amour Venter, Kim Narunsky, Anka Mekota, Sonja Henne, Angela Colbers, Georgette Plemper van Balen, Stephen Henry Gillespie, Patrick P J Phillips, Michael Hoelscher,
Lancet Infectious Diseases 2017 vol. 17 pp. 39-49
Improved power for TB phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods Robin Svensson, Stephen Henry Gillespie, Ulrika Simonsson
Journal of Antimicrobial Chemotherapy 2017 vol. 72 pp. 2311-2319
Label-free optical vibrational spectroscopy to detect the metabolic state of M. tuberculosis cells at the site of disease Mingzhou Chen, Simon O. Clark, Ann Williams, Kishan Dholakia, Stephen Henry Gillespie
Scientific Reports 2017 vol. 7
MRSA transmission dynamics among interconnected acute, intermediate-term, and long-term healthcare facilities in Singapore Angela Chow, Vanessa W Lim, Ateeb Khan, Kerry Andrea Pettigrew, David C B Lye, Kala Kanagasabai, Kelvin Phua, Prabha Krishnan, Brenda Ang, Kalisvar Marimuthu, Pei-Yun Hon, Jocelyn Koh, Ian Leong, Julian Parkhill, Li-Yang Hsu, Matthew Holden
Clinical Infectious Diseases 2017 vol. 64 pp. S76-S81
Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice Bruno Pichon, Michel Doumith, Julian Parkhill, Henrik Westh, Alexander Tomasz, Herminia de Lencastre, Stephen D Bentley, Angela M Kearns, Matthew Holden
Genome Biology 2017 vol. 18
Mycobacterial load assay Stephen Henry Gillespie, Wilber Sabiiti, Katarina Oravcova
2017 pp. 89-105
Pharmacokinetics, tolerability, and bacteriological response of rifampin administered at 600, 900, and 1,200 milligrams daily in patients with pulmonary tuberculosis R. E. Aarnoutse, G. S. Kibiki, K. Reither, H. H. Semvua, F. Haraka, C. M. Mtabho, S. G. Mpagama, J. van den Boogaard, I. M. Sumari-de Boer, C. Magis-Escurra, M. Wattenberg, J. G.M. Logger, L. H.M. te Brake, M. Hoelscher, Stephen Henry Gillespie, A. Colbers, P. P. J. Phillips, G. Plemper van Balen, M. J. Boeree,
Antimicrobial Agents and Chemotherapy 2017 vol. 61
Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns Tjibbe Donker, Sandra Reuter, James Scriberras, Rosy Reynolds, Nicholas M Brown, M Estée Török, Richard James, East Of England Microbiology Research Network, David M. Aanensen, Stephen D Bentley, Matthew Holden, Julian Parkhill, Brian G Spratt, Sharon J Peacock, Edward J Feil, Hajo Grundmann
Microbial Genomics 2017 vol. 3
Project Sanitarium Iain Donald, Karen Meyer, John Brengman, Stephen Henry Gillespie, Ruth Bowness
Journal of Computing in Higher Education 2017 vol. 29 pp. 599-617
ST3268 Li-Yang Hsu, Matthew Holden, Tse Hsien Koh, Kerry Andrea Pettigrew, Delphine Cao, Pei-Yun Hon, Darvi M Sergio, Edgar Pena, Bryan E Ogden
Journal of Antimicrobial Chemotherapy 2017 vol. 72 pp. 2401-2403
Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis Michael E. Murphy, Patrick P J Phillips, Carl M Mendel, Emily Bongard, Anna L C Bateson, Robert Hunt, Saraswathi Murthy, Kasha P. Singh, Michael Brown, Angela M Crook, Andrew J Nunn, Sarah K. Meredith, Marc Lipman, Timothy D. McHugh, Stephen Henry Gillespie,
BMC Medicine 2017 vol. 15
The genetic diversity of Staphylococcus aureus colonisation in atopic eczema disease flare Kerry Andrea Pettigrew, Katarina Oravcova, J. Gardner, R. Hearn, D. Rice, A. E. Mather, J. Parkhill, C. M. Proby, Matthew Holden
Journal of Investigative Dermatology 2017 vol. 137 pp. S258-S258
The implications of model–informed drug discovery and development for tuberculosis Morris Muliaditan, Geraint R Davies, Ulrika S. H. Simonsson, Stephen Henry Gillespie, Oscar Della Pasqua
Drug Discovery Today 2017 vol. 22 pp. 481-486
The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria Matthew J Ellington, Oskar Ekelund, Frank M. Aarestrup, Rafael Canton, Michel Doumith, Christian Giske, Hajo Grundman, Henrik Hasman, Matthew Holden, Katie L. Hopkins, Jon Iredell, Gunnar Kahlmeter, Claudio U Köser, Alasdair MacGowan, Dik Mevius, Mike Mulvey, Thierry Naas, Tim Peto, Jean-Marc Rolain, Ørjan Samuelsen, Neil Woodford
Clinical Microbiology and Infection 2017 vol. 23 pp. 2-22
Whole genome sequencing for surveillance of antimicrobial resistance in Actinobacillus pleuropneumoniae Janine T Bossé, Yanwen Li, Jon Rogers, Roberto Fernandez Crespo, Yinghui Li, Roy R Chaudhuri, Matthew Holden, Duncan J Maskell, Alexander W Tucker, Brendan W Wren, Andrew N Rycroft, Paul R Langford,
Frontiers in Microbiology 2017 vol. 8
Whole-genome sequencing to investigate a non-clonal melioidosis cluster on a remote Australian island Derek S. Sarovich, Stephanie N. J. Chapple, Erin P. Price, Mark Mayo, Matthew Holden, Sharon J Peacock, Bart J Currie
Microbial Genomics 2017 vol. 3
A new trial design to accelerate tuberculosis drug development Patrick P. J. Phillips, Kelly E. Dooley, Stephen Henry Gillespie, Norbert Heinrich, Jason E. Stout, Payam Nahid, Andreas H. Diacon, Rob E. Aarnoutse, Gibson S. Kibiki, Martin J. Boeree, Michael Hoelscher
BMC Medicine 2016 vol. 14 pp. 1-11
Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland Sandra Reuter, Estee M Török, Matthew Holden, Rosy Reynolds, Kathy E Raven, Beth Blane, Tjibbe Donker, Stephen D Bentley, David M Aanensen, Hajo Grundmann, Edward J Feil, Brian G Spratt, Julian Parkhill, Sharon J Peacock
Genome Research 2016 vol. 26 pp. 263-270
Complete genome sequence of MIDG2331, a genetically tractable serovar 8 clinical isolate of Actinobacillus pleuropneumoniae Janine T Bossé, Roy R Chaudhuri, Yanwen Li, Leon G Leanse, Roberto Fernandez Crespo, Paul Coupland, Matthew Holden, Denise M Bazzolli, Duncan J Maskell, Alexander W Tucker, Brendan W Wren, Andrew N Rycroft, Paul R Langford,
Genome Announcements 2016 vol. 4
Defining dormancy in mycobacterial disease Y. Hu, A. Coates, Stephen Henry Gillespie
Tuberculosis 2016 vol. 99 pp. 131-142
Erratum to: Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials Patrick P J Phillips, Carl M Mendel, Divan A Burger, Angela M Crook, Andrew J Nunn, Rodney Dawson, Andreas H Diacon, Stephen Henry Gillespie
BMC Medicine 2016 vol. 14
Evaluation of the healthcare burden of Idiopathic Pulmonary Fibrosis (IPF) in Fife, Scotland Devesh Janardan Dhasmana, Frances Harrison, Thomas Hartley, David Szapiro
2016
Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus A. M. Bal, G. W. Coombs, Matthew Holden, J. A. Lindsay, G. R. Nimmo, P. Tattevin, R. L. Skov
Journal of Global Antimicrobial Resistance 2016 vol. 6 pp. 95-101
Genomics of natural populations of Staphylococcus aureus J Ross Fitzgerald, Matthew Holden
Annual Review of Microbiology 2016 vol. 70 pp. 459-478
Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP) Stefano Aliberti, Luis F Reyes, Paola Faverio, Giovanni Sotgiu, Simone Dore, Alejandro H Rodriguez, Nilam J Soni, Marcos I Restrepo, Devesh Janardan Dhasmana
Lancet Infectious Diseases 2016 vol. 16 pp. 1364-1376
ICEApl1, an integrative conjugative element related to ICEHin1056, identified in the pig pathogen Actinobacillus pleuropneumoniae Janine T. Bosse, Yanwen Li, Roberto Fernandez Crespo, Roy R. Chaudhuri, Jon Rogers, Matthew Holden, Duncan J. Maskell, Alexander W. Tucker, Brendan W. Wren, Andrew N. Rycroft, Paul R. Langford,
Frontiers in Microbiology 2016 vol. 7
Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials Patrick P. J. Phillips, Carl M. Mendel, Divan A. Burger, Angela Crook, Andrew J. Nunn, Rodney Dawson, Andreas H. Diacon, Stephen Henry Gillespie
BMC Medicine 2016 vol. 14
Microreact: visualizing and sharing data for genomic epidemiology and phylogeography Silvia Argimón, Khalil Abudahab, Richard J. E. Goater, Artemij Fedosejev, Jyothish Bhai, Corinna Glasner, Edward J Feil, Matthew Holden, Corin A Yeats, Hajo Grundmann, Brian G Spratt, David M Aanensen
Microbial Genomics 2016 vol. 2
Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings Wilber Sabiiti, Bariki Mtafya, Davis Kuchaka, Khalide Azam, Sofia Vegas, Aaron Mdolo, Margaret Khonga, Dimitrios Evangelopoulos, Isobella Honeyborne, Andrea Rachow, Norbert Heinrich, Nyanda Elias Ntinginya, Nilesh Bhatt, Gerry R Davies, Ilesh V Jani, Timothy D McHugh, Gibson Kibiki, Michael Hoelscher, Stephen Henry Gillespie,
International Journal of Tuberculosis and Lung Disease 2016 vol. 20 pp. 1004-1009
Pan-genomic perspective on the evolution of the Staphylococcus aureus USA300 epidemic Dorota M Jamrozy, Simon R Harris, Naglaa Mohamed, Sharon J Peacock, Charles Y Tan, Julian Parkhill, Annaliesa S Anderson, Matthew Holden
Microbial Genomics 2016 vol. 2 pp. 1-14
Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy Isobella Honeyborne, Timothy D. McHugh, Iitu Kuittinen, Anna Cichonska, Dimitrios Evangelopoulos, Katharina Ronacher, Paul D. van Helden, Stephen Henry Gillespie, Delmiro Fernandez-Reyes, Gerhard Walzl, Juho Rousu, Philip D. Butcher, Simon J. Waddell
BMC Medicine 2016 vol. 14 pp. 1-13
Structured Reporting Forms (SRF) And A Pilot Study In Interstitial Lung Disease (ILD) and Idiopathic Pulmonary Fibrosis (IPF) D. Szapiro, L. Bidaut, A. Gangi, Thomas Nicholas Hartley, Devesh Janardan Dhasmana
American Journal of Respiratory and Critical Care Medicine 2016 vol. 193
The Ess/Type VII secretion system of Staphylococcus aureus shows unexpected genetic diversity Ben Warne, Catriona P Harkins, Simon R Harris, Alexandra Vatsiou, Nicola Stanley-Wall, Julian Parkhill, Sharon J Peacock, Tracy Palmer, Matthew Holden
BMC Genomics 2016 vol. 17 pp. 222
The role of moxifloxacin in tuberculosis therapy Stephen Henry Gillespie
European Respiratory Review 2016 vol. 25 pp. 19-28
Therapy for Tuberculous Meningitis Martin J Boeree, Stephen Henry Gillespie, Michael Hoelscher,
New England Journal of Medicine 2016 vol. 374 pp. 2187-8
Whole-genome sequencing for routine pathogen surveillance in public health David M Aanensen, Edward J Feil, Matthew Holden, Janina Dordel, Corin A Yeats, Artemij Fedosejev, Richard Goater, Santiago Castillo-Ramirez, Jukka Corander, Caroline Colijn, Monika A Chlebowicz, Leo Schouls, Max Heck, Gerlinde Pluister, Raymond Ruimy, Gunnar Kahlmeter, Jenny Åhman, Erika Matuschek, Alexander W Friedrich, Julian Parkhill, Stephen D Bentley, Brian G Spratt, Hajo Grundmann,
mBio 2016 vol. 7 pp. 1-15
Whole-genome sequencing of a quarter-century melioidosis outbreak in temperate Australia uncovers a region of low-prevalence endemicity Stephanie N J Chapple, Derek S Sarovich, Matthew Holden, Sharon J Peacock, Nicky Buller, Clayton Golledge, Bart J Currie, Mark Mayo, Erin P Price
Microbial Genomics 2016 vol. 2
Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles Tannistha Nandi, Matthew Holden, Xavier Didelot, Kurosh Mehershahi, Justin A Boddey, Ifor Beacham, Ian Peak, John Harting, Primo Baybayan, Yan Guo, Susana Wang, Lee Chee How, Bernice Sim, Angela Essex-Lopresti, Mitali Sarkar-Tyson, Michelle Nelson, Sophie Smither, Catherine Ong, Lay Tin Aw, Chua Hui Hoon, Stephen Michell, David J Studholme, Richard Titball, Swaine L Chen, Julian Parkhill, Patrick Tan
Genome Research 2015 vol. 25 pp. 129-141
Plasmodium knowlesi Janet Cox-Singh, Richard Culleton
Trends in Parasitology 2015 vol. 31
Plasmodium knowlesi genome sequences from clinical isolates reveal extensive genomic dimorphism Miguel Monsanto Pinheiro, Md Atique Ahmed, Theo Sanderson, Thomas D Otto, Woon Chan Lu, Sanjeev Krishna, Julian C Rayner, Janet Cox-Singh
PLoS One 2015 vol. 10
Plasmodium knowlesi – an emerging pathogen M.A. Ahmed, Janet Cox-Singh
ISBT Science Series 2015 vol. 10 pp. 134-140
A Step toward an Optimized Rifampin Dose Completed Martin J Boeree, Andreas H Diacon, Rodney Dawson, Kim Narunsky, Jeannine du Bois, Amour Venter, Patrick P J Phillips, Stephen Henry Gillespie, Timothy D McHugh, Michael Hoelscher, Norbert Heinrich, Sunita Rehal, Dick van Soolingen, Jakko van Ingen, Cecile Magis-Escurra, David Burger, Georgette Plemper van Balen, Rob E Aarnoutse
American Journal of Respiratory and Critical Care Medicine 2015 vol. 192 pp. 525-6
A dose ranging trial to optimize the dose of Rifampin in the treatment of tuberculosis Martin J Boeree, Andreas H Diacon, Rodney Dawson, Kim Narunsky, Jeannine du Bois, Amour Venter, Patrick P J Phillips, Stephen Henry Gillespie, Timothy D Mc Hugh, Michael Hoelscher, Norbert Heinrich, Sunita Rehal, Dick van Soolingen, Jakko van Ingen, Cecile Magis-Escurra, David Burger, Georgette Plemper van Balen, Rob E Aarnoutse,
American Journal of Respiratory and Critical Care Medicine 2015 vol. 191 pp. 1058-1065
Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission Gavin K Paterson, Ewan M Harrison, Gemma G R Murray, John J Welch, James H Warland, Matthew Holden, Fiona J E Morgan, Xiaoliang Ba, Gerrit Koop, Simon R Harris, Duncan J Maskell, Sharon J Peacock, Michael E Herrtage, Julian Parkhill, Mark A Holmes
Nature Communications 2015 vol. 6
Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae Janine T Bossé, Yanwen Li, Tom G Atherton, Stephanie Walker, Susanna M Williamson, Jon Rogers, Roy R Chaudhuri, Lucy A Weinert, Matthew Holden, Duncan J Maskell, Alexander W Tucker, Brendan W Wren, Andrew N Rycroft, Paul R Langford,
Veterinary Microbiology 2015 vol. 178 pp. 279-82
Colony morphology variation of Burkholderia pseudomallei is associated with antigenic variation and O-polysaccharide modifications Chanthiwa Wikraiphat, Natnaree Saiprom, Sarunporn Tandhavanant, Christian Heiss, Parastoo Azadi, Gumphol Wongsuvan, Apichai Tuanyok, Matthew Holden, Mary N Burtnick, Paul J Brett, Sharon J Peacock, Narisara Chantratita
Infection and Immunity 2015 vol. 83 pp. 2127-2138
Development of a multilocus sequence typing scheme for the molecular typing of Mycoplasma pneumoniae Rebecca J. Brown, Matthew Holden, O. Brad Spiller, Victoria J. Chalker
Journal of Clinical Microbiology 2015 vol. 53 pp. 3195-3203
Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients Norbert Heinrich, Rodney Dawson, Jeannine du Bois, Kim Narunsky, Gary Horwith, Andrew J Phipps, Carol A Nacy, Rob E Aarnoutse, Martin J Boeree, Stephen Henry Gillespie, Amour Venter, Sonja Henne, Andrea Rachow, Patrick P J Phillips, Michael Hoelscher, Andreas H Diacon,
Journal of Antimicrobial Chemotherapy 2015
Effective anti-tuberculosis therapy correlates with plasma small RNA Isobella Honeyborne, Marc C Lipman, Clare Eckold, Dimitrios Evangelopoulos, Stephen Henry Gillespie, Alexander Pym, Timothy D McHugh
European Respiratory Journal 2015 vol. 45 pp. 1741-1744
Emergence of a new highly successful acapsular Group A Streptococcus clade of the genotype emm89 in the United Kingdom Claire E. Turner, James Abbott, Theresa Lamagni, Matthew Holden, Sophia David, Michael D. Jones, Laurence Game, Androulla Efstratiou, Shiranee Sriskandan
mBio 2015 vol. 6
Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus M.J. Ellington, S. Reuter, S.R. Harris, Matthew Holden, E.J. Cartwright, D. Greaves, S.M. Gerver, R. Hope, N.M. Brown, M.E. Török, J. Parkhill, C.U. Köser, S.J. Peacock
International Journal of Antimicrobial Agents 2015 vol. 45 pp. 477-484
Evolutionary dynamics of methicillin-resistant Staphylococcus aureus within a healthcare system Li-Yang Hsu, Simon R Harris, Monika A Chlebowicz, Jodi A Lindsay, Tse-Hsien Koh, Prabha Krishnan, Thean-Yen Tan, Pei-Yun Hon, Warren B Grubb, Stephen D Bentley, Julian Parkhill, Sharon J Peacock, Matthew Holden
Genome Biology 2015 vol. 16
Evolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureus Maisem Laabei, Anne-Catrin Uhlemann, Franklin D Lowy, Eloise D Austin, Maho Yokoyama, Khadija Ouadi, Edward Feil, Harry A Thorpe, Barnabas Williams, Mark Perkins, Sharon J Peacock, Stephen R Clarke, Janina Dordel, Matthew Holden, Antonina A Votintseva, Rory Bowden, Derrick W Crook, Bernadette C Young, Daniel J Wilson, Mario Recker, Ruth C Massey
PLoS Biology 2015 vol. 13
Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection Simon R Harris, Carl Robinson, Karen F Steward, Katy S Webb, Romain Paillot, Julian Parkhill, Matthew Holden, Andrew S Waller
Genome Research 2015 vol. 25 pp. 1360-1371
Genomic investigations unmask Mycoplasma amphoriforme, a new respiratory pathogen Stephen Henry Gillespie, Clare L Ling, Katarina Oravcova, Miguel Pinheiro, Louise Wells, Josephine M Bryant, Timothy D McHugh, Cecile Bébéar, David Webster, Simon R Harris, Helena M B Seth-Smith, Nicholas Robert Thomson
Clinical Infectious Diseases 2015 vol. 60 pp. 381-388
Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis Lucy A Weinert, Roy R Chaudhuri, Jinhong Wang, Sarah E Peters, Jukka Corander, Thibaut Jombart, Abiyad Baig, Kate J Howell, Minna Vehkala, Niko Välimäki, David Harris, Tran Thi Bich Chieu, Nguyen Van Vinh Chau, James Campbell, Constance Schultsz, Julian Parkhill, Stephen D Bentley, Paul R Langford, Andrew N Rycroft, Brendan W Wren, Jeremy Farrar, Stephen Baker, Ngo Thi Hoa, Matthew Holden, Alexander W Tucker, Duncan J Maskell,
Nature Communications 2015 vol. 6
HspX knock-out in Mycobacterium tuberculosis leads to shorter antibiotic treatment and lower relapse rate in a mouse model - A potential novel therapeutic target Yanmin Hu, Alexander Liu, Maria C. Menendez, Maria J. Garcia, Katarina Oravcova, Stephen Henry Gillespie, Gerry R. Davies, Denis A. Mitchison, Anthony R. M. Coates
Tuberculosis 2015 vol. 95 pp. 31-36
Human infections with Plasmodium knowlesi - zoonotic malaria Janet Cox-Singh
Clinical Microbiology and Infection 2015 vol. 21 pp. 640-648
Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae Janine T Bossé, Yanwen Li, Stephanie Walker, Tom Atherton, Roberto Fernandez Crespo, Susanna M Williamson, Jon Rogers, Roy R Chaudhuri, Lucy A Weinert, Olusegun Oshota, Matthew Holden, Duncan J Maskell, Alexander W Tucker, Brendan W Wren, Andrew N Rycroft, Paul R Langford,
Journal of Antimicrobial Chemotherapy 2015 vol. 70 pp. 2217-2222
Old drugs to treat resistant bugs Xiaoliang Ba, Ewan M Harrison, Andrew L Lovering, Nicholas Gleadall, Ruth Zadoks, Julian Parkhill, Sharon J Peacock, Matthew Holden, Gavin K Paterson, Mark A Holmes
Antimicrobial Agents and Chemotherapy 2015 vol. 59 pp. 7396-7404
Phenotypic resistance in mycobacteria Katarina Oravcova, Stephen Henry Gillespie
Journal of Antimicrobial Chemotherapy 2015 vol. Advance Access
PinR mediates the generation of reversible population diversity in Streptococcus zooepidemicus Karen Frances Steward, Tihana Harrison, Carl Robinson, Josh Slater, Duncan J Maskell, Simon R Harris, Matthew Holden, Andrew S Waller
Microbiology 2015 vol. 161 pp. 1105-1112
Project Sanitarium Iain Donald, Karen Meyer, Stephen Henry Gillespie, Ruth Bowness, John Brengman
2015
Roary Andrew J Page, Carla A Cummins, Martin Hunt, Vanessa K Wong, Sandra Reuter, Matthew Holden, Maria Fookes, Daniel Falush, Jacqueline A Keane, Julian Parkhill
Bioinformatics (Oxford, England) 2015 vol. Advance Access
Shorter moxifloxacin-based regimens for drug-sensitive tuberculosis Stephen Henry Gillespie, Carl M Mendel, Patrick P. J. Phillips,
New England Journal of Medicine 2015 vol. 372 pp. 577-577
Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus Eike J Steinig, Patiyan Andersson, Simon R Harris, Derek S Sarovich, Anand Manoharan, Paul Coupland, Matthew Holden, Julian Parkhill, Stephen D Bentley, D Ashley Robinson, Steven Yc Tong
BMC Genomics 2015 vol. 16
T cell immunity to the alkyl hydroperoxide reductase of Burkholderia pseudomallei Catherine Reynolds, Amélie Goudet, Kemajittra Jenjaroen, Manutsanun Sumonwiriya, Darawan Rinchai, Julie Musson, Saskia Overbeek, Julia Makinde, Kathryn Quigley, Jiten Manji, Natasha Spink, Pagnarith Yos, Vanaporn Wuthiekanun, Gregory Bancroft, John Robinson, Ganjana Lertmemongkolchai, Susanna Dunachie, Bernard Maillere, Matthew Holden, Daniel Altmann, Rosemary Boyton
The Journal of Immunology 2015 vol. 194 pp. 4814-4824
The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations Ruth Bowness, Martin J Boeree, Rob Aarnoutse, Rodney Dawson, Andreas Diacon, Chacha Mangu, Norbert Heinrich, Nyanda E Ntinginya, Anke Kohlenberg, Bariki Mtafya, Patrick P J Phillips, Andrea Rachow, Georgette Plemper van Balen, Stephen Henry Gillespie
Journal of Antimicrobial Chemotherapy 2015 vol. 70 pp. 448-455
Turner et al. Reply to "Emergence of the same successful clade among distinct populations of emm89 Streptococcus pyogenes in multiple geographic regions" Claire E Turner, Theresa Lamagni, Matthew Holden, Sophia David, Michael D Jones, Laurence Game, Androulla Efstratiou, Shiranee Sriskandan
mBio 2015 vol. 6
Whole genome investigation of a divergent clade of the pathogen Streptococcus suis Abiyad Baig, Lucy A Weinert, Sarah E Peters, Kate J Howell, Roy R Chaudhuri, Jinhong Wang, Matthew Holden, Julian Parkhill, Paul R Langford, Andrew N Rycroft, Brendan W Wren, Alexander W Tucker, Duncan J Maskell
Frontiers in Microbiology 2015 vol. 6 pp. 1191
Whole-genome sequencing confirms that Burkholderia pseudomallei multilocus sequence types common to both Cambodia and Australia are due to homoplasy Birgit De Smet, Derek S Sarovich, Erin P Price, Mark Mayo, Vanessa Theobald, Chun Kham, Seiha Heng, Thong Phe, Matthew Holden, Julian Parkhill, Sharon J Peacock, Brian G Spratt, Jan Jacobs, Peter Vandamme, Bart J Currie
Journal of Clinical Microbiology 2015 vol. 53 pp. 323-326
In vivo evolution of antimicrobial resistance in a series of Staphylococcus aureus patient isolates Sebastiaan J van Hal, Jason A Steen, Björn A Espedido, Sean M Grimmond, Matthew A Cooper, Matthew Holden, Stephen D Bentley, Iain B Gosbell, Slade O Jensen
Journal of Antimicrobial Chemotherapy 2014 vol. 69 pp. 363-7
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline Violette Da Cunha, Mark R Davies, Pierre-Emmanuel Douarre, Isabelle Rosinski-Chupin, Immaculada Margarit, Sebastien Spinali, Tim Perkins, Pierre Lechat, Nicolas Dmytruk, Elisabeth Sauvage, Laurence Ma, Benedetta Romi, Magali Tichit, Maria-José Lopez-Sanchez, Stéphane Descorps-Declere, Erika Souche, Carmen Buchrieser, Patrick Trieu-Cuot, Ivan Moszer, Dominique Clermont, Domenico Maione, Christiane Bouchier, David J McMillan, Julian Parkhill, John L Telford, Gordan Dougan, Mark J Walker, Matthew Holden, Claire Poyart, Philippe Glaser,
Nature Communications 2014 vol. 5 pp. 4544
A novel hybrid SCCmec-mecC region in Staphylococcus sciuri Ewan M Harrison, Gavin K Paterson, Matthew Holden, Xiaoliang Ba, Joana Rolo, Fiona J E Morgan, Bruno Pichon, Angela Kearns, Ruth N Zadoks, Sharon J Peacock, Julian Parkhill, Mark A Holmes
Journal of Antimicrobial Chemotherapy 2014 vol. 69 pp. 911-918
A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals Ewan M Harrison, Lucy A Weinert, Matthew Holden, John J Welch, Katherine Wilson, Fiona J E Morgan, Simon R Harris, Anette Loeffler, Amanda K Boag, Sharon J Peacock, Gavin K Paterson, Andrew S Waller, Julian Parkhill, Mark A Holmes
mBio 2014 vol. 5
Community-acquired pneumonia and tuberculosis R.F. Grossman, P.-R. Hsueh, Stephen Henry Gillespie, F. Blasi
International Journal of Infectious Diseases 2014 vol. 18 pp. 14-21
Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members Atique M. Ahmed, Miguel Monsanto Pinheiro, Paul C. Divis, Angela Siner, Ramlah Zainudin, Ing Tien Wong, Chan Woon Lu, Sarina K. Singh-Khaira, Sean Lynch, Matthias Willmann, Balbir Singh, Sanjeev Krishna, Janet Cox-Singh
PLoS Neglected Tropical Diseases 2014 vol. 8
Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance Mark R Davies, Matthew Holden, Paul Coupland, Jonathan H K Chen, Carola Venturini, Timothy C Barnett, Nouri L Ben Zakour, Herman Tse, Gordon Dougan, Kwok-Yung Yuen, Mark J Walker
Nature Genetics 2014
Evaluation of three rapid diagnostic tests for the detection of human infections with Plasmodium knowlesi Deshka Foster, Janet Cox-Singh, Dayang S. A. Mohamad, Sanjeev Krishna, Pek P. Chin, Balbir Singh
Malaria Journal 2014 vol. 13
Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis Stephen Henry Gillespie, Angela M. Crook, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Stephen R. Murray, Frances Pappas, Patrick P.J. Phillips, Andrew J. Nunn,
New England Journal of Medicine 2014 vol. 371 pp. 1577-1587
Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting Steven Y C Tong, Matthew Holden, Emma K Nickerson, Ben S Cooper, Claudio U Köser, Anne Cori, Thibaut Jombart, Simon Cauchemez, Christophe Fraser, Vanaporn Wuthiekanun, Janjira Thaipadungpanit, Maliwan Hongsuwan, Nicholas P Day, Direk Limmathurotsakul, Julian Parkhill, Sharon J Peacock
Genome Research 2014 vol. 25 pp. 111-118
Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus Lucy Hepburn, Tomasz K Prajsnar, Catherine Klapholz, Pablo Moreno, Catherine A Loynes, Nikolay V Ogryzko, Karen Brown, Mark Schiebler, Krisztina Hegyi, Robin Antrobus, Katherine L Hammond, John Connolly, Bernardo Ochoa, Clare Bryant, Michael Otto, Bas Surewaard, Suranjith L Seneviratne, Dorothy M Grogono, Julien Cachat, Tor Ny, Arthur Kaser, M Estée Török, Sharon J Peacock, Matthew Holden, Tom Blundell, Lihui Wang, Petros Ligoxygakis, Liliana Minichiello, C Geoff Woods, Simon J Foster, Stephen A Renshaw, R Andres Floto
Science 2014 vol. 346 pp. 641-6
Micro-evolution of Burkholderia pseudomallei during an acute infection Direk Limmathurotsakul, Matthew Holden, Paul Coupland, Erin P Price, Narisara Chantratita, Vanaporn Wuthiekanun, Premjit Amornchai, Julian Parkhill, Sharon J Peacock
Journal of Clinical Microbiology 2014
Molecular tracing of the emergence, diversification, and transmission of S. aureus sequence type 8 in a New York community Anne-Catrin Uhlemann, Janina Dordel, Justin R Knox, Kathy E Raven, Julian Parkhill, Matthew Holden, Sharon J Peacock, Franklin D Lowy
Proceedings of the National Academy of Sciences of the United States of America 2014 vol. 111 pp. 6738–6743
Multiplex PCR Assay for unequivocal differentiation of Actinobacillus pleuropneumoniae serovars 1 to 3, 5 to 8, 10, and 12 Janine T Bossé, Yanwen Li, Oystein Angen, Lucy A Weinert, Roy R Chaudhuri, Matt T Holden, Susanna M Williamson, Duncan J Maskell, Alexander W Tucker, Brendan W Wren, Andrew N Rycroft, Paul R Langford, Matthew Holden
Journal of Clinical Microbiology 2014 pp. 2380-2385
New antituberculosis drugs, regimens, and adjunct therapies Alimuddin I Zumla, Stephen Henry Gillespie, Michael Hoelscher, Patrick P J Philips, Stewart T Cole, Ibrahim Abubakar, Timothy D McHugh, Marco Schito, Markus Maeurer, Andrew J Nunn
Lancet Infectious Diseases 2014 vol. 14 pp. 327-40
Novel determinants of antibiotic resistance Janina Dordel, Choonkeun Kim, Marilyn Chung, María Pardos de la Gándara, Matthew Holden, Julian Parkhill, Hermínia de Lencastre, Stephen D Bentley, Alexander Tomasz
mBio 2014 vol. 5
Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene Xiaoliang Ba, Ewan M Harrison, Giles F Edwards, Matthew Holden, Anders Rhod Larsen, Andreas Petersen, Robert L Skov, Sharon J Peacock, Julian Parkhill, Gavin K Paterson, Mark A Holmes
Journal of Antimicrobial Chemotherapy 2014 vol. 69 pp. 594-7
Performance of Xpert MTB/RIF in the diagnosis of tuberculous mediastinal lymphadenopathy by endobronchial ultrasound Devesh Janardan Dhasmana, Clare Ross, Clare J Bradley, David W Connell, Peter M George, Aran Singanayagam, Annette Jepson, Clare Craig, Corrina Wright, Philip L Molyneaux, Melissa Wickremasinghe, Ajit Lalvani, Graham S Cooke, Onn Min Kon
Annals of the American Thoracic Society 2014 vol. 11 pp. 392-6
Predicting the virulence of MRSA from its genome sequence Maisem Laabei, Mario Recker, Justine K Rudkin, Mona Aldeljawi, Zeynep Gulay, Tim J Sloan, Paul Williams, Jennifer L Endres, Kenneth W Bayles, Paul D Fey, Vijaya Kumar Yajjala, Todd Widhelm, Erica Hawkins, Katie Lewis, Sara Parfett, Lucy Scowen, Sharon J Peacock, Matthew Holden, Daniel Wilson, Timothy D Read, Jean van den Elsen, Nicholas K Priest, Edward J Feil, Laurence D Hurst, Elisabet Josefsson, Ruth C Massey
Genome Research 2014 vol. 24 pp. 839-849
The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis Kate J Howell, Lucy A Weinert, Roy R Chaudhuri, Shi-Lu Luan, Sarah E Peters, Jukka Corander, David Harris, Øystein Angen, Virginia Aragon, Albert Bensaid, Susanna M Williamson, Julian Parkhill, Paul R Langford, Andrew N Rycroft, Brendan W Wren, Matthew Holden, Alexander W Tucker, Duncan J Maskell
BMC Genomics 2014 vol. 15
Tools for detection of Mycoplasma amphoriforme Clare L. Ling, Katarina Oravcova, Thomas Ferris Beattie, Dean D. Creer, Paul Dilworth, Naomi L. Fulton, Alison Hardie, Michelle Munro, Marcus Pond, Kate Templeton, David Webster, Sarita Workman, Timothy D. McHugh, Stephen Henry Gillespie
Journal of Clinical Microbiology 2014 vol. 52 pp. 1177-1181
Tuberculosis new treatments in evolution Stephen Henry Gillespie
2014
Whole-genome sequencing reveals clonal expansion of multiresistant Staphylococcus haemolyticus in European hospitals Jorunn Pauline Cavanagh, Erik Hjerde, Matthew Holden, Tim Kahlke, Claus Klingenberg, Trond Flægstad, Julian Parkhill, Stephen D Bentley, Johanna U Ericson Sollid
Journal of Antimicrobial Chemotherapy 2014 vol. 69 pp. 2920-2927
Zero tolerance for healthcare-associated MRSA bacteraemia M Estée Török, Simon R Harris, Edward J P Cartwright, Kathy E Raven, Nicholas M Brown, Michael E D Allison, Daniel Greaves, Michael A Quail, Direk Limmathurotsakul, Matthew Holden, Julian Parkhill, Sharon J Peacock
Journal of Antimicrobial Chemotherapy 2014
A Staphylococcus xylosus Isolate with a new mecC Allotype Ewan M. Harrison, Gavin K. Paterson, Matthew Holden, Fiona J. E. Morgan, Anders Rhod Larsen, Andreas Petersen, Sabine Leroy, Sarne De Vliegher, Vincent Perreten, Lawrence K. Fox, Theo J. G. M. Lam, Otlis C. Sampimon, Ruth N. Zadoks, Sharon J. Peacock, Julian Parkhill, Mark A. Holmes
Antimicrobial Agents and Chemotherapy 2013 vol. 57 pp. 1524-1528
A Single Multilocus Sequence Typing (MLST) scheme for seven pathogenic Leptospira Species Siriphan Boonsilp, Janjira Thaipadungpanit, Premjit Amornchai, Vanaporn Wuthiekanun, Mark S. Bailey, Matthew Holden, Cuicai Zhang, Xiugao Jiang, Nobuo Koizumi, Kyle Taylor, Renee Galloway, Alex R. Hoffmaster, Scott Craig, Lee D. Smythe, Rudy A. Hartskeerl, Nicholas P. Day, Narisara Chantratita, Edward J. Feil, David M. Aanensen, Brian G. Spratt, Sharon J. Peacock
PLoS Neglected Tropical Diseases 2013 vol. 7
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic Matthew Holden, Li-Yang Hsu, Kevin Kurt, Lucy A. Weinert, Alison E. Mather, Simon R. Harris, Birgit Strommenger, Franziska Layer, Wolfgang Witte, Herminia de Lencastre, Robert Skov, Henrik Westh, Helena Zemlickova, Geoffrey Coombs, Angela M. Kearns, Robert L. R. Hill, Jonathan Edgeworth, Ian Gould, Vanya Gant, Jonathan Cooke, Giles F. Edwards, Paul R. McAdam, Kate E. Templeton, Angela McCann, Zhemin Zhou, Santiago Castillo-Ramirez, Edward J. Feil, Lyndsey O. Hudson, Mark C. Enright, Francois Balloux, David M. Aanensen, Brian G. Spratt, J. Ross Fitzgerald, Julian Parkhill, Mark Achtman, Stephen D. Bentley, Ulrich Nuebel
Genome Research 2013 vol. 23 pp. 653-664
Arginine Catabolic Mobile Element in Methicillin-Resistant Staphylococcus aureus (MRSA) Clonal Group ST239-MRSA-III Isolates in Singapore: Implications for PCR-Based Screening Tests Pei Yun Hon, Kian Sing Chan, Matthew Holden, Simon R. Harris, Thean Yen Tan, Yan-Bing Zu, Prabha Krishnan, Lynette L. Oon, Tse Hsien Koh, Li Yang Hsu
Antimicrobial Agents and Chemotherapy 2013 vol. 57 pp. 1563-1564
Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment Sven Olaf Friedrich, Andrea Rachow, Elmar Saathoff, Kasha Singh, Chacha D Mangu, Rodney Dawson, Patrick Phillips, Amour Venter, Anna Bateson, Catharina C Boehme, Norbert Heinrich, Robert Hunt, Martin J Boeree, Alimudden Zumla, Timothy D McHugh, Stephen Henry Gillespie, Andreas Diacon, Michael Hoelscher
The Lancet Respiratory Medicine 2013 vol. 1 pp. 462-470
Chasing Koch's chimera Paul Klatser, Richard Anthony, Clifton Barry, Francis Drobniewski, Sven Hoffner, Stefan Niemann, Stephen Henry Gillespie
The Lancet Infectious Diseases 2013 vol. 13 pp. 289-291
Clinical trials in tuberculosis chemotherapy Stephen Henry Gillespie
2013 pp. 197-205
Direct comparison of Xpert MTB/RIF assay with liquid and solid mycobacterial culture for quantification of early bactericidal activity Xavier A. Kayigire, Sven O. Friedrich, Amour Venter, Rodney Dawson, Stephen Henry Gillespie, Martin J. Boeree, Norbert Heinrich, Michael Hoelscher, Andreas H. Diacon
Journal of Clinical Microbiology 2013 vol. 51 pp. 1894-1898
MDR/XDRTB Stephen Henry Gillespie
Current Respiratory Medicine Reviews 2013 vol. 9 pp. 211-216
Molecular analysis of an outbreak of lethal postpartum sepsis caused by Streptococcus pyogenes Claire E. Turner, Matthew Dryden, Matthew Holden, Frances J. Davies, Richard A. Lawrenson, Leili Farzaneh, Stephen D. Bentley, Androulla Efstratiou, Shiranee Sriskandan
Journal of Clinical Microbiology 2013 vol. 51 pp. 2089-2095
Rapid Bacterial Whole-Genome Sequencing to Enhance Diagnostic and Public Health Microbiology Sandra Reuter, Matthew J. Ellington, Edward J. P. Cartwright, Claudio U. Koeser, M. Estee Toeroek, Theodore Gouliouris, Simon R. Harris, Nicholas M. Brown, Matthew Holden, Mike Quail, Julian Parkhill, Geoffrey P. Smith, Stephen D. Bentley, Sharon J. Peacock
JAMA Internal Medicine 2013 vol. 173 pp. 1397-1404
Rapid single-colony whole-genome sequencing of bacterial pathogens Claudio U Köser, Louise J Fraser, Avgousta Ioannou, Jennifer Becq, Matthew J Ellington, Matthew Holden, Sandra Reuter, M Estée Török, Stephen D Bentley, Julian Parkhill, Niall A Gormley, Geoffrey P Smith, Sharon J Peacock
Journal of Antimicrobial Chemotherapy 2013
Susceptibility of human plasmodium knowlesi infections to anti-malarials Farrah A. Fatih, Henry M. Staines, Angela Siner, Mohammed Atique Ahmed, Lu Chan Woon, Erica M. Pasini, Clemens H. M. Kocken, Balbir Singh, Janet Cox-Singh, Sanjeev Krishna
Malaria Journal 2013 vol. 12
When is an outbreak not an outbreak? Robert J Shorten, Alistair C McGregor, S Platt, Claire, M Jenkins, Marc L Lipman, Stephen Henry Gillespie, Bambos M Charalambous, Timothy D McHugh
Journal of Antimicrobial Chemotherapy 2013 vol. 68 pp. 543-549
Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC Ewan M. Harrison, Gavin K. Paterson, Matthew Holden, Jesper Larsen, Marc Stegger, Anders Rhod Larsen, Andreas Petersen, Robert L. Skov, Judit Marta Christensen, Anne Bak Zeuthen, Ole Heltberg, Simon R. Harris, Ruth N. Zadoks, Julian Parkhill, Sharon J. Peacock, Mark A. Holmes
Embo Molecular Medicine 2013 vol. 5 pp. 509-515
Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus Simon R. Harris, Edward J. P. Cartwright, M. Estee Toeroek, Matthew Holden, Nicholas M. Brown, Amanda L. Ogilvy-Stuart, Matthew J. Ellington, Michael A. Quail, Stephen D. Bentley, Julian Parkhill, Sharon J. Peacock
Lancet Infectious Diseases 2013 vol. 13 pp. 130-136
Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis Josephine M Bryant, Simon R Harris, Julian Parkhill, Rodney Dawson, Andreas Diacon, Paul van Helden, Alex Pym, Aziah Ahmad Mahayiddin, C Chuchottaworn, Ian M Sanne, Cheryl Louw, Martin J Boeree, Michael Hoelscher, Timothy D McHugh, Anna L C Bateson, Robert D Hunt, Solomon Mwaigwisya, Laura Wright, Stephen Henry Gillespie, Stephen D Bentley
The Lancet Respiratory Medicine 2013 vol. 1 pp. 786–792
An improved method for detection of pyrazinamide resistance in Mycobacterium tuberculosis Amani Alnimr, Timothy D. McHugh, Stephen Henry Gillespie
International Journal of Mycobacteriology 2012 vol. 1 pp. 104-105
BURKHOLDERIA CEPACIA COMPLEX AND LIMITED CUTANEOUS VASCULITIS K. Muttardi, C. Orchard, N. Simmonds, K. Gyi, D. Bilton, Devesh Janardan Dhasmana
Pediatric pulmonology 2012 vol. 47 pp. 344-344
Comparative genomics of vancomycin-resistant Staphylococcus aureus strains and their positions within the clade most commonly associated with methicillin-resistant S. aureus hospital-acquired infection in the United States Veronica N. Kos, Christopher A. Desjardins, Allison Griggs, Gustavo Cerqueira, Andries Van Tonder, Matthew Holden, Paul Godfrey, Kelli L. Palmer, Kip Bodi, Emmanuel F. Mongodin, Jennifer Wortman, Michael Feldgarden, Trevor Lawley, Steven R. Gill, Brian J. Haas, Bruce Birren, Michael S. Gilmore
mBio 2012 vol. 3
Cytoadherence and virulence - the case of Plasmodium knowlesi malaria Farrah A. Fatih, Angela Siner, Atique Ahmed, Lu Chan Woon, Alister G. Craig, Balbir Singh, Sanjeev Krishna, Janet Cox-Singh
Malaria Journal 2012 vol. 11
Detection and identification of bacteria in clinical samples by 16S rRNA gene sequencing: comparison of two different approaches in clinical practice Claire Jenkins, Clare L. Ling, Holly L. Ciesielczuk, Julianne Lockwood, Susan Hopkins, Timothy D. McHugh, Stephen Henry Gillespie, Christopher C. Kibbler
Journal of Medical Microbiology 2012 vol. 61 pp. 483-488
Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing plasmodium parasites based on enzyme activity measurement Sissel Juul, Christine J F Nielsen, Rodrigo Labouriau, Amit Roy, Cinzia Tesauro, Pia W. Jensen, Charlotte Harmsen, Emil L. Kristoffersen, Ya Ling Chiu, Rikke Frohlich, Paola Fiorani, Janet Cox-Singh, David Tordrup, Jorn Koch, Anne Lise Bienvenu, Alessandro Desideri, Stephane Picot, Eskild Petersen, Kam W. Leong, Yi Ping Ho, Magnus Stougaard, Birgitta R. Knudsen
ACS Nano 2012 vol. 6 pp. 10676-10683
GeneDB-an annotation database for pathogens Flora J. Logan-Klumpler, Nishadi De Silva, Ulrike Boehme, Matthew B. Rogers, Giles Velarde, Jacqueline A. McQuillan, Tim Carver, Martin Aslett, Christian Olsen, Sandhya Subramanian, Isabelle Phan, Carol Farris, Siddhartha Mitra, Gowthaman Ramasamy, Haiming Wang, Adrian Tivey, Andrew Jackson, Robin Houston, Julian Parkhill, Matthew Holden, Omar S. Harb, Brian P. Brunk, Peter J. Myler, David Roos, Mark Carrington, Deborah F. Smith, Christiane Hertz-Fowler, Matthew Berriman
Nucleic Acids Research 2012 vol. 40 pp. D98-D108
Guidelines for Reporting Novel mecA Gene Homologues Teruyo Ito, Keiichi Hiramatsu, Alexander Tomasz, Herminia de Lencastre, Vincent Perreten, Matthew Holden, David C. Coleman, Richard Goering, Philip M. Giffard, Robert L. Skov, Kunyan Zhang, Henrik Westh, Frances O'Brien, Fred C. Tenover, Duarte C. Oliveira, Susan Boyle-Vavra, Frederic Laurent, Angela M. Kearns, Barry Kreiswirth, Kwan Soo Ko, Hajo Grundmann, Johanna E. Sollid, Joseph F. John, Robert Daum, Bo Soderquist, Girbe Buist,
Antimicrobial Agents and Chemotherapy 2012 vol. 56 pp. 4997-4999
Innovative Trial Designs Are Practical Solutions for Improving the Treatment of Tuberculosis Patrick P. J. Phillips, Stephen Henry Gillespie, Martin Boeree, Norbert Heinrich, Rob Aarnoutse, Tim McHugh, Michel Pletschette, Christian Lienhardt, Richard Hafner, Charles Mgone, Alimuddin Zumla, Andrew J. Nunn, Michael Hoelscher
Journal of Infectious Diseases 2012 vol. 205 pp. S250-S257
Laboratory markers of disease severity in Plasmodium knowlesi infection: a case control study Matthias Willmann, Atique Ahmed, Angela Siner, Ing Tien Wong, Lu Chan Woon, Balbir Singh, Sanjeev Krishna, Janet Cox-Singh
Malaria Journal 2012 vol. 11
Managing malaria in tuberculosis patients on fluoroquinolone-containing regimens: assessing the risk of QT prolongation. Kasha Singh, Martino laurenzi, Mike Brown, Stephen Henry Gillespie
International Journal of Tuberculosis and Lung Disease 2012 vol. 16 pp. 144-149
Medical Microbiology and Infection at a Glance Stephen Henry Gillespie, Kathleen Bamford
2012
Molecular tracing of the emergence, adaptation, and transmission of hospital-associated methicillin-resistant Staphylococcus aureus Paul R. McAdam, Kate E. Templeton, Giles F. Edwards, Matthew Holden, Edward J. Feil, David M. Aanensen, Hiba J. A. Bargawi, Brian G. Spratt, Stephen D. Bentley, Julian Parkhill, Mark C. Enright, Anne Holmes, E. Kirsty Girvan, Paul A. Godfrey, Michael Feldgarden, Angela M. Kearns, Andrew Rambaut, D. Ashley Robinson, J. Ross Fitzgerald
Proceedings of the National Academy of Sciences of the United States of America 2012 vol. 109 pp. 9107-9112
Moxifloxacin for tuberculosis Kasha Priya Singh, Michael Brown, Michael E. Murphy, Stephen Henry Gillespie
Lancet Infectious Diseases 2012 vol. 12 pp. 176-176
Phylogeographic variation in recombination rates within a global clone of methicillin-resistant Staphylococcus aureus Santiago Castillo-Ramirez, Jukka Corander, Pekka Marttinen, Mona Aldeljawi, William P. Hanage, Henrik Westh, Kit Boye, Zeynep Gulay, Stephen D. Bentley, Julian Parkhill, Matthew Holden, Edward J. Feil
Genome Biology 2012 vol. 13
Properties of a novel PBP2a protein homolog from Staphylococcus aureus strain LGA251 and its contribution to the β-lactam-resistant phenotype Choonkeun Kim, Catarina Milheirico, Susana Gardete, Mark A. Holmes, Matt T. G. Holden, Herminia de Lencastre, Alexander Tomasz, Matthew Holden
Journal of Biological Chemistry 2012 vol. 287 pp. 36854-36863
Rapid Whole-Genome Sequencing for Investigation of a Neonatal MRSA Outbreak Claudio U. Koeser, Matthew Holden, Matthew J. Ellington, Edward J. P. Cartwright, Nicholas M. Brown, Amanda L. Ogilvy-Stuart, Li Yang Hsu, Claire Chewapreecha, Nicholas J. Croucher, Simon R. Harris, Mandy Sanders, Mark C. Enright, Gordon Dougan, Stephen D. Bentley, Julian Parkhill, Louise J. Fraser, Jason R. Betley, Ole B. Schulz-Trieglaff, Geoffrey P. Smith, Sharon J. Peacock
New England Journal of Medicine 2012 vol. 366 pp. 2267-2275
Routine use of microbial whole genome sequencing in diagnostic and public health microbiology Claudio U. Koeser, Matthew J. Ellington, Edward J. P. Cartwright, Stephen Henry Gillespie, Nicholas M. Brown, Mark Farrington, Matthew T. G. Holden, Gordon Dougan, Stephen D. Bentley, Julian Parkhill, Sharon J. Peacock
PLoS Pathogens 2012 vol. 8
SUCCESSFUL CORRECTION OF VITAMIN D LEVELS WITH HIGH-DOSE SUPPLEMENTATION K. Rowland-Jones, Devesh Janardan Dhasmana, E. Bowman, A. Maidman, Susan Collins, N. Simmonds
Pediatric pulmonology 2012 vol. 47 pp. 411-412
Sequetyping Marcus Leung, Kevin Bryson, Kathrin Freystatter, Bruno Pichon, Giles Edwards, Bambos Charalambous, Stephen Henry Gillespie
Journal of Clinical Microbiology 2012 vol. 50 pp. 2419-2427
Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery Geoff Coxon, Christopher Cooper, Stephen Henry Gillespie, Timothy McHugh
Journal of Infectious Diseases 2012 vol. supplement pp. S1-7
Streptococcus pseudopneumoniae Identification by Pherotype: a Method To Assist Understanding of a Potentially Emerging or Overlooked Pathogen Marcus H. Leung, Clare L. Ling, Holly Ciesielczuk, Julianne Lockwood, Sarah Thurston, Bambos M. Charalambous, Stephen Henry Gillespie
Journal of Clinical Microbiology 2012 vol. 50 pp. 1684-1690
Superantigenic Activity of emm3 Streptococcus pyogenes Is Abrogated by a Conserved, Naturally Occurring smeZ Mutation Claire E. Turner, Mary Sommerlad, Karen McGregor, Frances J. Davies, Bruno Pichon, Deborah L. W. Chong, Leili Farzaneh, Matthew Holden, Brian G. Spratt, Androulla Efstratiou, Shiranee Sriskandan
PLoS ONE 2012 vol. 7
Zoonotic malaria Janet Cox-Singh
Current Opinion in Infectious Diseases 2012 vol. 25 pp. 530-536
Plasmodium knowlesi Kim-Sung Lee, Paul C. S. Divis, Siti Khatijah Zakaria, Asmad Matusop, Roynston A. Julin, David J. Conway, Janet Cox-Singh, Balbir Singh
PLoS Pathogens 2011 vol. 7
A Very Early-Branching Staphylococcus aureus Lineage Lacking the Carotenoid Pigment Staphyloxanthin Deborah C. Holt, Matthew Holden, Steven Y. C. Tong, Santiago Castillo-Ramirez, Louise Clarke, Michael A. Quail, Bart J. Currie, Julian Parkhill, Stephen D. Bentley, Edward J. Feil, Philip M. Giffard
Genome Biology and Evolution 2011 vol. 3 pp. 881-895
Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections Janet Cox-Singh, Balbir Singh, Cyrus Daneshvar, Timothy Planche, John Parker-Williams, Sanjeev Krishna, Janet Cox-Singh
PLoS One 2011 vol. 6
Anti-mycobacterial Drugs Stephen Henry Gillespie, Michael Murphy
Encyclopaedia of Life Sciences (eLS) 2011
Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei Narisara Chantratita, Drew A. Rholl, Bernice Sim, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Premjit Amornchai, Aunchalee Thanwisai, Hui Hoon Chua, Wen Fong Ooi, Matthew Holden, Nicholas P. Day, Patrick Tan, Herbert P. Schweizer, Sharon J. Peacock
Proceedings of the National Academy of Sciences of the United States of America 2011 vol. 108 pp. 17165-17170
Blood culture bottle culture of pleural fluid in pleural infection Sarah Menzies, Najib Rahman, John Wrightson, Helen Davies, Rob Shorten, Stephen Henry Gillespie, Christopher Davies, Nick Maskell, Andrew Jeffrey, Gary Lee, Rob Davies
Thorax 2011 vol. 66 pp. 658-662
Comparative whole genome sequence analysis of the carcinogenic bacterial model pathogen Helicobacter felis Isabelle C. Arnold, Zuzana Zigova, Matthew Holden, Trevor D. Lawley, Roland Rad, Gordon Dougan, Stanley Falkow, Stephen D. Bentley, Anne Mueller
Genome Biology and Evolution 2011 vol. 3 pp. 302-308
Fluoroquinolones in the management of tuberculosis Stephen Henry Gillespie, Kasha Singh
2011 vol. 40 pp. 51-60
Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors Simon Heilbronner, Matthew Holden, Andries van Tonder, Joan A. Geoghegan, Timothy J. Foster, Julian Parkhill, Stephen D. Bentley
FEMS Microbiology Letters 2011 vol. 322 pp. 60-67
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark Laura Garcia-Alvarez, Matthew Holden, Heather Lindsay, Cerian R. Webb, Derek F. J. Brown, Martin D. Curran, Enid Walpole, Karen Brooks, Derek J. Pickard, Christopher Teale, Julian Parkhill, Stephen D. Bentley, Giles F. Edwards, E. Kirsty Girvan, Angela M. Kearns, Bruno Pichon, Robert L. R. Hill, Anders Rhod Larsen, Robert L. Skov, Sharon J. Peacock, Duncan J. Maskell, Mark A. Holmes
Lancet Infectious Diseases 2011 vol. 11 pp. 595-603
Molecular Bacterial Load Assay, a Culture-Free Biomarker for Rapid and Accurate Quantification of Sputum Mycobacterium tuberculosis Bacillary Load during Treatment Isobella Honeyborne, Timothy D. McHugh, Patrick Phillips, Selina Bannoo, Anna Bateson, N Carroll, Felicity Perrin, Katharina Ronacher, Laura Wright, Paul van Helden, Gerhart Walzl, Stephen Henry Gillespie
Journal of Clinical Microbiology 2011 vol. 49 pp. 3905-3911
The adaptive potential during nasopharyngeal colonisation of Streptococcus pneumoniae Marcus Leung, Ndeky Oriyo, Stephen Henry Gillespie, Bambos Charalambous
Infection Genetics and Evolution 2011 vol. 11 pp. 1989-1995
The impact of recombination on dN/dS within recently emerged bacterial clones Santiago Castillo-Ramirez, Simon R. Harris, Matthew Holden, Miao He, Julian Parkhill, Stephen D. Bentley, Edward J. Feil
PLoS Pathogens 2011 vol. 7
Tuberculosis: forgotten but not gone Stephen Henry Gillespie
Mircobiology Today 2011 vol. 38 pp. 34-37
Why Do We Use 600 mg of Rifampicin in Tuberculosis Treatment? Jakko van Ingen, Rob E. Aarnoutse, Peter R. Donald, Andreas H. Diacon, Rodney Dawson, Georgette Plemper van Balen, Stephen Henry Gillespie, Martin J. Boeree
Clinical Infectious Diseases 2011 vol. 52 pp. E194-E199
XDR-TB, What is it; How is it Treated; and Why is Therapeutic Failure so High? Stephen Henry Gillespie, Kasha Singh
Recent Patents Anti-infective Drug Discovery 2011 vol. 6 pp. 77
Antimicrobial treatment and clinical outcome for infections with carbapenem- and multiply-resistant Acinetobacter baumannii around London David M. Livermore, Robert L.R. Hill, Hazel Thomson, André Charlett, Jane F. Turton, Rachel Pike, Bharat C. Patel, Rohini Manuel, Stephen Henry Gillespie, Indran Balakrishnan, Stephen P. Barrett, Nigel Cumberland, Mary Twagira,
International Journal of Antimicrobial Agents 2010 vol. 35 pp. 19-24
Approaches to measure the fitness of Burkholderia cepacia complex isolates C. F. Pope, Stephen Henry Gillespie, J. E. Moore, T. D. McHugh
Journal of Medical Microbiology 2010 vol. 59 pp. 679-686
Characterization of Pneumonia Due to Streptococcus equi subsp. zooepidemicus in Dogs Simon L. Priestnall, Kerstin Erles, Harriet W. Brooks, Jacqueline M. Cardwell, Andrew S. Waller, Romain Paillot, Carl Robinson, Alistair C. Darby, Matthew Holden, Sandra Schoeniger
Clinical and Vaccine Immunology 2010 vol. 17 pp. 1790-1796
Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections Cyrus Daneshvar, Timothy M. E. Davis, Janet Cox-Singh, Mohammad Z. Rafa'ee, Siti K. Zakaria, Paul C. S. Divis, Balbir Singh
Malaria Journal 2010 vol. 9
Comment TB - Strength in numbers Geoffrey D. Coxon, Stephen Henry Gillespie
Microbiology Today 2010 vol. 37
Evolution of MRSA During Hospital Transmission and Intercontinental Spread Simon R. Harris, Edward J. Feil, Matthew Holden, Michael A. Quail, Emma K. Nickerson, Narisara Chantratita, Susana Gardete, Ana Tavares, Nick Day, Jodi A. Lindsay, Jonathan D. Edgeworth, Herminia de Lencastre, Julian Parkhill, Sharon J. Peacock, Stephen D. Bentley
Science 2010 vol. 327 pp. 469-474
Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW) Matthew Holden, Jodi A. Lindsay, Craig Corton, Michael A. Quail, Joshua D. Cockfield, Smriti Pathak, Rahul Batra, Julian Parkhill, Stephen D. Bentley, Jonathan D. Edgeworth
Journal of Bacteriology 2010 vol. 192 pp. 888-892
Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen Burkholderia pseudomallei K96243 Andrea J. Dowling, Paul Wilkinson, Matthew Holden, Michael A. Quail, Stephen D. Bentley, Julia Reger, Nicholas R. Waterfield, Richard W. Titball, Richard H. Ffrench-Constant
PLoS ONE 2010 vol. 5
High Rates of Homologous Recombination in the Mite Endosymbiont and Opportunistic Human Pathogen Orientia tsutsugamushi Piengchan Sonthayanon, Sharon J. Peacock, Wirongrong Chierakul, Vanaporn Wuthiekanun, Stuart D. Blacksell, Mathew T. G. Holden, Stephen D. Bentley, Edward J. Feil, Nicholas P. J. Day, Matthew Holden
PLoS Neglected Tropical Diseases 2010 vol. 4
Identification of Three Novel Superantigen-Encoding Genes in Streptococcus equi subsp zooepidemicus, szeF, szeN, and szeP Romain Paillot, Alistair C. Darby, Carl Robinson, Nicola L. Wright, Karen F. Steward, Emma Anderson, Katy Webb, Matthew Holden, Androulla Efstratiou, Karen Broughton, Keith A. Jolley, Simon L. Priestnall, Maria C. Marotti Campi, Margaret A. Hughes, Alan Radford, Kerstin Erles, Andrew S. Waller
Infection and Immunity 2010 vol. 78 pp. 4817-4827
Impact of Cotrimoxazole on Carriage and Antibiotic Resistance of Streptococcus pneumoniae and Haemophilus influenzae in HIV-Infected Children in Zambia Darlington M. Mwenya, Bambos M. Charalambous, Paul Jonathan Phillips, James C. L. Mwansa, Sarah L. Batt, Andrew J. Nunn, Diana M. Gibb, Stephen Henry Gillespie
Antimicrobial Agents and Chemotherapy 2010 vol. 54 pp. 3756-3762
Malaria: what can apes teach humans? Janet Cox-Singh, Janet Cox-Singh
Future Microbiology 2010 vol. 5 pp. 1157-1160
Mapping the fitness of Mycobacterium tuberculosis strains, a complex picture D. M. O'Sullivan, T. D. McHugh, Stephen Henry Gillespie
Journal of Medical Microbiology 2010 vol. 59 pp. 1533-1535
Mapping the fitness of Mycobacterium tuberculosis strains: a complex picture. Stephen Henry Gillespie, Denise M. O'Sullivan , Timothy D. McHugh
Journal of Medical Microbiology 2010
Methods to determine fitness in bacteria. Stephen Henry Gillespie, Cassie F Pope, Timothy D. McHugh
2010 vol. 642 pp. 113-121
Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens Ambroise D. Ahouidi, Amy K. Bei, Daniel E. Neafsey, Ousmane Sarr, Sarah Volkman, Dan Milner, Janet Cox-Singh, Marcelo U. Ferreira, Omar Ndir, Zul Premji, Souleymane Mboup, Manoj T. Duraisingh, Janet Cox-Singh
Infection Genetics and Evolution 2010 vol. 10 pp. 200-206
Radiological cavitation, sputum mycobacterial load and treatment response in pulmonary tuberculosis Felicity Perrin , Nicholas Woodward, Patrick Phillips, Timothy McHugh, Andrew Nunn, Marc Lipman, Stephen Henry Gillespie
International Journal of Tuberculosis and Lung Disease 2010 vol. 14 pp. 1596-1602
Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings Janet Cox-Singh, Jessie Hiu, Sebastian B. Lucas, Paul C. Divis, Mohammad Zulkarnaen, Patricia Chandran, Kum T. Wong, Patricia Adem, Sherif R. Zaki, Balbir Singh, Sanjeev Krishna
Malaria Journal 2010 vol. 9
Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now! Leonard Amaral, Martin J. Boeree, Stephen Henry Gillespie, Zarir F. Udwadia, Dick van Soolingen
International Journal of Antimicrobial Agents 2010 vol. 35 pp. 524-526
Plasmodium knowlesi from archival blood films Kim-Sung Lee, Janet Cox-Singh, George Brooke, Asmad Matusop, Balbir Singh
International Journal for Parasitology 2009 vol. 39 pp. 1125-1128
A Practical Guide to Measuring Mutation Rates in Antibiotic Resistance (vol 52, pg 1209, 2008) Cassie F. Pope, Denise M. O'Sullivan, Timothy D. McHugh, Stephen Henry Gillespie
Antimicrobial Agents and Chemotherapy 2009 vol. 53 pp. 339-339
Are patients on treatment for pulmonary TB who stop expectorating sputum genuinely culture negative? F. M. R. Perrin, R. A. M. Breen, T. D. McHugh, Stephen Henry Gillespie, M. C. I. Lipman
Thorax 2009 vol. 64 pp. 1009-1010
Audit of laboratory diagnostic methods for syphilis in England and Wales A. K. Amin, R. J. Manuel, C. A. Ison, R. Woodham, M. Shemko, H. Maguire, I. Giraudon, J. Forde, Stephen Henry Gillespie
Sexually Transmitted Infections 2009 vol. 85 pp. 88-91
Clinical and Laboratory Features of Human Plasmodium knowlesi Infection Cyrus Daneshvar, Timothy M. E. Davis, Janet Cox-Singh, Mohammad Zakri Rafa'ee, Siti Khatijah Zakaria, Paul C. S. Divis, Balbir Singh
Clinical Infectious Diseases 2009 vol. 49 pp. 852-860
DEVELOPMENT OF AN ADULT "CYSTIC FIBROSIS SWINE FLU TRIAGE SERVICE'' IN A LONDON TERTIARY REFERRAL CENTRE Devesh Janardan Dhasmana, K. Dack, K. Gyi, M. E. Hodson, D. Bilton
Thorax 2009 vol. 64 pp. A174-A174
Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH Claire Jenkins, Joanna Bacon, Jon Allnutt, Kim A. Hatch, Alpana Bose, Denise M. O'Sullivan, Catherine Arnold, Stephen Henry Gillespie, Timothy D. McHugh
Journal of Antimicrobial Chemotherapy 2009 vol. 63 pp. 1118-1120
Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis Philip N. Ward, Matthew Holden, James A. Leigh, Nicola Lennard, Alexandra Bignell, Andy Barron, Louise Clark, Michael A. Quail, John Woodward, Bart G. Barrell, Sharon A. Egan, Terence R. Field, Duncan Maskell, Michael Kehoe, Christopher G. Dowson, Neil Chanter, Adrian M. Whatmore, Stephen D. Bentley, Julian Parkhill
BMC Genomics 2009 vol. 10
Genomic evidence for the evolution of Streptococcus equi Matthew Holden, Zoe Heather, Romain Paillot, Karen F. Steward, Katy Webb, Fern Ainslie, Thibaud Jourdan, Nathalie C. Bason, Nancy E. Holroyd, Karen Mungall, Michael A. Quail, Mandy Sanders, Mark Simmonds, David Willey, Karen Brooks, David M. Aanensen, Brian G. Spratt, Keith A. Jolley, Martin C. J. Maiden, Michael Kehoe, Neil Chanter, Stephen D. Bentley, Carl Robinson, Duncan J. Maskell, Julian Parkhill, Andrew S. Waller
PLoS Pathogens 2009 vol. 5
Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH Qosay Al-Balas, Nahoum G. Anthony, Bilal Al-Jaidi, Amani Alnimr, Grainne Abbott, Alistair K. Brown, Rebecca C. Taylor, Gurdyal S. Besra, Timothy D. McHugh, Stephen Henry Gillespie, Blair F. Johnston, Simon P. Mackay, Geoffrey D. Coxon
PLoS ONE 2009 vol. 4 pp. e5617
Knowlesi malaria in Vietnam Janet Cox-Singh
Malaria Journal 2009 vol. 8
Medical Microbiology and Infection at a Glance Stephen Henry Gillespie, Kathleen Bamford
2009
Micro-geographic risk factors for malarial infection Ward P. Myers, Andrea P. Myers, Janet Cox-Singh, Hui C. Lau, Benny Mokuai, Richard Malley
Malaria Journal 2009 vol. 8
Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen streptococcus suis Matthew Holden, Heidi Hauser, Mandy Sanders, Thi Hoa Ngo, Inna Cherevach, A Cronin, Ian Goodhead, Karen Mungall, Michael A. Quail, Claire Price, Ester Rabbinowitsch, Sarah Sharp, Nicholas J. Croucher, Tran Bich Chieu, Nguyen Thi Hoang Mai, To Song Diep, Nguyen Tran Chinh, Michael Kehoe, James A. Leigh, Philip N. Ward, Christopher G. Dowson, Adrian M. Whatmore, Neil Chanter, Pernille Iversen, Marcelo Gottschalk, Josh D. Slater, Hilde E. Smith, Brian G. Spratt, Jianguo Xu, Changyun Ye, Stephen Bentley, Barclay G. Barrell, Constance Schultsz, Duncan J. Maskell, Julian Parkhill
PLoS One 2009 vol. 4
The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients Matthew Holden, Helena M. B. Seth-Smith, Lisa C. Crossman, Mohammed Sebaihia, Stephen D. Bentley, Ana M. Cerdeno-Tarraga, Nicholas Robert Thomson, Nathalie Bason, Michael A. Quail, Sarah Sharp, Inna Cherevach, Carol Churcher, Ian Goodhead, Heidi Hauser, Nancy Holroyd, Karen Mungall, Paul Scott, Danielle Walker, Brian White, Helen Rose, Pernille Iversen, Dalila Mil-Homens, Eduardo P. C. Rocha, Arsenio M. Fialho, Adam Baldwin, Christopher Dowson, Bart G. Barrell, John R. Govan, Peter Vandamme, C. Anthony Hart, Eshwar Mahenthiralingam, Julian Parkhill
Journal of Bacteriology 2009 vol. 191 pp. 261-277
The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients (vol 191, pg 261, 2009) Matthew Holden, Helena M. B. Seth-Smith, Lisa C. Crossman, Mohammed Sebaihia, Stephen D. Bentley, Ana M. Cerdeno-Tarraga, Nicholas Robert Thomson, Nathalie Bason, Michael A. Quail, Sarah Sharp, Inna Cherevach, Carol Churcher, Ian Goodhead, Heidi Hauser, Nancy Holroyd, Karen Mungall, Paul Scott, Danielle Walker, Brian White, Helen Rose, Pernille Iversen, Dalila Mil-Homens, Eduardo P. C. Rocha, Arsenio M. Fialho, Adam Baldwin, Christopher Dowson, Bart G. Barrell, John R. Govan, Peter Vandamme, C. Anthony Hart, Eshwar Mahenthiralingam, Julian Parkhill
Journal of Bacteriology 2009 vol. 191 pp. 2907-2907
The Streptococcus equi prophage-encoded protein SEQ2045 is a hyaluronan-specific hyaluronate lyase that is produced during equine infection Anna-Marie Lindsay, Meng Zhang, Zoe Mitchell, Matthew Holden, Andrew S. Waller, Iain C. Sutcliffe, Gary W. Black
Microbiology 2009 vol. 155 pp. 443-449
Think TB! Is the diagnosis of pulmonary tuberculosis delayed by the use of antibiotics? S. E. Craig, H. Bettinson, C. A. Sabin, Stephen Henry Gillespie,
International Journal of Tuberculosis and Lung Disease 2009 vol. 13 pp. 208-213
Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin D. M. O'Sullivan, J. Hinds, P. D. Butcher, Stephen Henry Gillespie, T. D. McHugh
Journal of Antimicrobial Chemotherapy 2008 vol. 62 pp. 1199-1202
Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening Janet Cox-Singh, Timothy M. E. Davis, Kim-Sung Lee, Sunita S. G. Shamsul, Asmad Matusop, Shanmuga Ratnam, Hasan A. Rahman, David J. Conway, Balbir Singh
Clinical Infectious Diseases 2008 vol. 46 pp. 165-171
A novel streptococcal integrative conjugative element involved in iron acquisition Zoe Heather, Matthew Holden, Karen F. Steward, Julian Parkhill, Lijiang Song, Gregory L. Challis, Carl Robinson, Nicholas Davis-Poynter, Andrew S. Waller
Molecular Microbiology 2008 vol. 70 pp. 1274-1292
A practical guide to measuring mutation rates in antibiotic resistance Cassie F. Pope, Denise M. O'Sullivan, Timothy D. McHugh, Stephen Henry Gillespie
Antimicrobial Agents and Chemotherapy 2008 vol. 52 pp. 1209-1214
Burkholderia pseudomallei genome plasticity associated with genomic island variation Sarinna Tumapa, Matthew Holden, Mongkol Vesaratchavest, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Wirongrong Chierakul, Edward J. Feil, Bart J. Currie, Nicholas P. J. Day, William C. Nierman, Sharon J. Peacock
BMC Genomics 2008 vol. 9
Chlamydia trachomatis: Genome sequence analysis of lymphogranuloma venereum isolates Nicholas Robert Thomson, Matthew Holden, Caroline Carder, Nicola Lennard, Sarah J. Lockey, Pete Marsh, Paul Skipp, C. David O'Connor, Ian Goodhead, Halina Norbertzcak, Barbara Harris, Doug Ormond, Richard Rance, Michael A. Quail, Julian Parkhill, Richard S. Stephens, Ian N. Clarke
Genome Research 2008 vol. 18 pp. 161-171
Clinical application of a rapid lung-orientated immunoassay in individuals with possible tuberculosis R. A. M. Breen, S. M. Barry, C. J. Smith, R. J. Shorten, J. P. Dilworth, I. Cropley, T. D. McHugh, Stephen Henry Gillespie, G. Janossy, M. C. I. Lipman
Thorax 2008 vol. 63 pp. 67-71