O'HARE RESEARCH GROUP

Research at the University of St Andrews School of Medicine

Publications

Recent publications listed in research@st-andrews

Tweed, CD, Crook, AM, Amukoye, EI, Dawson, R, Diacon, AH, Hanekom, M, McHugh, TD, Mendel, CM, Meredith, SK, Murphy, ME, Murthy, SE, Nunn, AJ, Phillips, PPJ, Singh, KP, Spigelman, M, Wills, GH & Gillespie, SH 2018, 'Toxicity associated with tuberculosis chemotherapy in the REMoxTB study' BMC Infectious Diseases, vol. 18, 317. DOI: 10.1186/s12879-018-3230-6
Svensson, EM, Svensson, RJ, Te Brake, LHM, Boeree, MJ, Heinrich, N, Konsten, S, Churchyard, G, Dawson, R, Diacon, AH, Kibiki, GS, Minja, LT, Ntingiya, NE, Sanne, I, Gillespie, SH, Hoelscher, M, Phillips, PPJ, Simonsson, USH & Aarnoutse, R 2018, 'The potential for treatment shortening with higher rifampicin doses: relating drug exposure to treatment response in patients with pulmonary tuberculosis' Clinical Infectious Diseases, vol. 67, no. 1, pp. 34-41. DOI: 10.1093/cid/ciy026
Murthy, SE, Chatterjee, F, Crook, A, Dawson, R, Mendel, C, Murphy, ME, Murray, SR, Nunn, AJ, Phillips, PPJ, Singh, KP, McHugh, TD, Gillespie, SH & REMoxTB Consortium 2018, 'Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis' BMC Medicine, vol. 16, 73. DOI: 10.1186/s12916-018-1053-3
Svensson, RJ, Svensson, EM, Aarnoutse, RE, Diacon, AH, Dawson, R, Gillespie, SH, Moodley, M, Boeree, MJ & Simonsson, USH 2018, 'Greater early bactericidal activity at higher rifampicin doses revealed by modeling and clinical trial simulations' Journal of Infectious Diseases, vol. In press. DOI: 10.1093/infdis/jiy242
Rachow, A, Saathoff, E, Mtafya, B, Mapamba, D, Mangu, C, Rojas-Ponce, G, Ntinginya, NE, Boeree, M, Heinrich, N, Gillespie, SH, Hoelscher, M & PanACEA Consortium 2018, 'The impact of repeated NALC/NaOH- decontamination on the performance of Xpert MTB/RIF assay' Tuberculosis, vol. In press. DOI: 10.1016/j.tube.2018.04.001
Fregonese, F, Ahuja, SD, Akkerman, OW, Arakaki-Sanchez, D, Ayakaka, I, Baghaei, P, Bang, D, Bastos, M, Benedetti, A, Bonnet, M, Cattamanchi, A, Cegielski, P, Chien, J-Y, Cox, H, Dedicoat, M, Erkens, C, Escalante, P, Falzon, D, Garcia-Prats, AJ, Gegia, M, Gillespie, SH, Glynn, JR, Goldberg, S, Griffith, D, Jacobson, KR, Johnston, JC, Jones-López, EC, Khan, A, Koh, W-J, Kritski, A, Lan, ZY, Lee, JH, Li, PZ, Maciel, EL, Galliez, RM, Merle, CSC, Munang, M, Narendran, G, Nguyen, VN, Nunn, A, Ohkado, A, Park, JS, Phillips, PPJ, Ponnuraja, C, Reves, R, Romanowski, K, Seung, K, Schaaf, HS, Skrahina, A, Soolingen, DV, Tabarsi, P, Trajman, A, Trieu, L, Banurekha, VV, Viiklepp, P, Wang, J-Y, Yoshiyama, T & Menzies, D 2018, 'Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis' The Lancet Respiratory Medicine, vol. 6, no. 4, pp. 265-275. DOI: 10.1016/S2213-2600(18)30078-X
Tweed, CD, Wills, GH, Crook, AM, Dawson, R, Diacon, AH, Louw, CE, McHugh, TD, Mendel, C, Meredith, S, Mohapi, L, Murphy, ME, Murray, S, Murthy, S, Nunn, AJ, Phillips, PPJ, Singh, K, Spigelman, M & Gillespie, SH 2018, 'Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study' BMC Medicine, vol. 16, 46. DOI: 10.1186/s12916-018-1033-7
Baron, VO, Chen, M, Clark, SO, Williams, A, Dholakia, K & Gillespie, SH 2018, Detecting phenotypically resistant Mycobacterium tuberculosis using wavelength modulated Raman spectroscopy. in S Gillespie (ed.), Antibiotic Resistance Protocols. Methods in Molecular Biology, vol. 1736, Humana Press/Springer, New York, NY, pp. 41-50. DOI: 10.1007/978-1-4939-7638-6_4
Hammond, RJH, Baron, VO, Lipworth, S & Gillespie, SH 2018, Enhanced methodologies for detecting phenotypic resistance in mycobacteria. in S Gillespie (ed.), Antibiotic Resistance Protocols. Methods in Molecular Biology, vol. 1736, Humana Press/Springer, New York, NY, pp. 85-94. DOI: 10.1007/978-1-4939-7638-6_8
Xaio, H & Gillespie, SH 2018, Using RT qPCR for quantifying Mycobacteria marinum from in vitro and in vivo samples. in S Gillespie (ed.), Antibiotic Resistance Protocols. Methods in Molecular Biology, vol. 1736, Humana Press/Springer, New York, NY, pp. 137-145. DOI: 10.1007/978-1-4939-7638-6_13
Madaline, TF, Hochman, SE, Seydel, KB, Liomba, A, Saidi, A, Matebule, G, Mowrey, WB, O'Hare, B, Milner Jr., DA & Kim, K 2017, 'Rapid diagnostic testing of hospitalized Malawian children reveals opportunities for improved HIV diagnosis and treatment' American Journal of Tropical Medicine and Hygiene, vol. 97, no. 6, pp. 1929-1935. DOI: 10.4269/ajtmh.17-0067
Mhango, T, Chapotera, G, Chipeta, E, O'Hare, BA-M, Samuel, V & Stones, W 2017, 'Understanding the health and well being of young adolescents' College of Medicine, Research Dissemination Forum, Blantyre, Malawi, 24/11/17 - 25/11/17, .
Chakakala-Chaziya, J, Patson, N & O'Hare, BA-M 2017, 'A comparison of virological suppression among different age groups attending QECH outpatient ART clinic and an analysis of associated factors among adolescents.' Research Dissemination Conference, Blantyre, Malawi, 24/11/17 - 25/11/17, .
Aarnoutse, RE, Kibiki, GS, Reither, K, Semvua, HH, Haraka, F, Mtabho, CM, Mpagama, SG, van den Boogaard, J, Sumari-de Boer, IM, Magis-Escurra, C, Wattenberg, M, Logger, JGM, te Brake, LHM, Hoelscher, M, Gillespie, SH, Colbers, A, Phillips, PPJ, Plemper van Balen, G, Boeree, MJ & PanACEA Consortium 2017, 'Pharmacokinetics, tolerability, and bacteriological response of rifampin administered at 600, 900, and 1,200 milligrams daily in patients with pulmonary tuberculosis' Antimicrobial Agents and Chemotherapy, vol. 61, no. 11, e01054-17. DOI: 10.1128/AAC.01054-17
Murphy, ME, Phillips, PPJ, Mendel, CM, Bongard, E, Bateson, ALC, Hunt, R, Murthy, S, Singh, KP, Brown, M, Crook, AM, Nunn, AJ, Meredith, SK, Lipman, M, McHugh, TD, Gillespie, SH & REMoxTB Consortium 2017, 'Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis' BMC Medicine, vol. 15, 192. DOI: 10.1186/s12916-017-0947-9
Macken, M, Chan, J, O'Hare, B, Thornton, HV, Dube, Q & Kennedy, N 2017, 'Bedside paediatric HIV testing in Malawi: impact on testing rates' Malawi Medical Journal, vol. 29, no. 3, pp. 237-239. DOI: 10.4314/mmj.v29i3.2
O'Hare, BA-M 2017, TB in childhood: protocols for the Department of Paediatrics and Child Health, QECH, Malawi. in The White Book, Protocols and Guidelines, The Department of Paediatrics and Child Health.
Muliaditan, M, Davies, GR, Simonsson, USH, Gillespie, SH & Pasqua, OD 2017, 'The implications of model–informed drug discovery and development for tuberculosis' Drug Discovery Today, vol. 22, no. 3, pp. 481-486. DOI: 10.1016/j.drudis.2016.09.004
Boeree, MJ, Heinrich, N, Aarnoutse, R, Diacon, AH, Dawson, R, Rehal, S, Kibiki, GS, Churchyard, G, Sanne, I, Ntinginya, NE, Minja, LT, Hunt, RD, Charalambous, S, Hanekom, M, Semvua, HH, Mpagama, SG, Manyama, C, Mtafya, B, Reither, K, Wallis, RS, Venter, A, Narunsky, K, Mekota, A, Henne, S, Colbers, A, Plemper van Balen, G, Gillespie, SH, Phillips, PPJ & Hoelscher, M 2017, 'High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial' Lancet Infectious Diseases, vol. 17, no. 1, pp. 39-49. DOI: 10.1016/S1473-3099(16)30274-2, 10.1016/S1473-3099(16)30274-2
Gillespie, SH, Sabiiti, W & Oravcova, K 2017, Mycobacterial load assay. in KA Bishop-Lilly (ed.), Diagnostic Bacteriology: Methods and Protocols. Methods in Molecular Biology, vol. 1616, Humana Press/Springer, New York, NY, pp. 89-105. DOI: 10.1007/978-1-4939-7037-7_5
Taylor, S & O'Hare, BA-M 2017, Social determinants of child health and social justice. in D Devakumar, J Hall, Z Qureshi & J Lawn (eds), Global Maternal and Child Health. Oxford University Press, Oxford.
Papageorghiou, AT, Kemp, B, Stones, W, Ohuma, EO, Kennedy, SH, Purwar, M, Salomon, LJ, Altman, DG, Noble, JA, Bertino, E, Gravett, MG, Pang, R, Cheikh Ismail, L, Barros, FC, Lambert, A, Jaffer, YA, Victora, CG, Bhutta, ZA, Villar, J & Internatinal Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) 2016, 'Ultrasound-based gestational-age estimation in late pregnancy' Ultrasound in Obstetrics & Gynecology, vol. 48, no. 6, pp. 719-726. DOI: 10.1002/uog.15894
O'Hare, BA-M (ed.), Kawaza, K, Mzikamanda, R & Molyneux, L 2016, Care of the infant and newborn in Malawi (2017): the COIN Course - Participants Manual. University of St Andrews.
Sabiiti, W, Mtafya, B, Kuchaka, D, Azam, K, Viegas, S, Mdolo, A, Farmer, E, Khonga, M, Evangelopoulos, D, Honeyborne, I, Rachow, A, Heinrich, N, Ntinginya, NE, Bhatt, N, Davies, GR, Jani, IV, McHugh, TD, Kibiki, G, Hoelscher, M, Gillespie, SH & PANBIOME (Pan-African Biomarker Expansion Programme) consortium 2016, 'Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings' International Journal of Tuberculosis and Lung Disease, vol. 20, no. 8, pp. 1004-1009. DOI: 10.5588/ijtld.15.0951
Lipworth, S, Hammond, RJH, Baron, VO, Hu, Y, Coates, A & Gillespie, SH 2016, 'Defining dormancy in mycobacterial disease' Tuberculosis, vol. 99, pp. 131-142. DOI: 10.1016/j.tube.2016.05.006
Boeree, MJ, Gillespie, SH, Hoelscher, M & PanACEA core team 2016, 'Therapy for Tuberculous Meningitis' New England Journal of Medicine, vol. 374, no. 22, pp. 2187-8. DOI: 10.1056/NEJMc1602291#SA2
Mwalukomo, T, Rylance, S, Webb, E, Anderson, S, O'Hare, BA-M, van Oosterhout, JJ, Ferrand, RA, Corbett, EL & Rylance, J 2016, 'Clinical characteristics and lung function in older children vertically infected with Human Immunodeficiency Virus in Malawi' Journal of the Pediatric Infectious Diseases Society, vol. 5, no. 2, pp. 161-169. DOI: 10.1093/jpids/piv045
Maken, M, O'Hare, BA-M & Kennedy, N 2016, 'Bedside testing improves HIV inpatient paediatric testing rates in a Malawian hospital, G270. Oral Presentation' RCPCH Annual Conference, Liverpool, United Kingdom, 26/04/16 - 28/04/16, . DOI: 10.1136/archdischild-2016-310863.262
Honeyborne, I, McHugh, TD, Kuittinen, I, Cichonska, A, Evangelopoulos, D, Ronacher, K, van Helden, PD, Gillespie, SH, Fernandez-Reyes, D, Walzl, G, Rousu, J, Butcher, PD & Waddell, SJ 2016, 'Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy' BMC Medicine, vol. 14, no. 1, pp. 1-13. DOI: 10.1186/s12916-016-0609-3
Phillips, PPJ, Dooley, KE, Gillespie, SH, Heinrich, N, Stout, JE, Nahid, P, Diacon, AH, Aarnoutse, RE, Kibiki, GS, Boeree, MJ & Hoelscher, M 2016, 'A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP)' BMC Medicine, vol. 14, 51, pp. 1-11. DOI: 10.1186/s12916-016-0597-3
Ismail, LC, Bishop, DC, Pang, R, Ohuma, EO, Kac, G, Abrams, B, Rasmussen, K, Barros, FC, Hirst, J, Lambert, A, Papageorghiou, AT, Stones, W, Jaffer, YA, Altman, DG, Noble, JA, Giolito, MR, Gravett, MG, Purwar, M, Kennedy, SH, Bhutta, ZA & Villar, J 2016, 'Gestational weight gain standards based on the women enrolled in the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project: a prospective longitudinal cohort study' British Medical Journal, vol. 352, i555. DOI: 10.1136/bmj.i555
The Lancet Ending Preventable Stillbirths Series study group & The Lancet Ending Preventable Stillbirths Series Advisory Group 2016, 'Stillbirths: ending preventable deaths by 2030' Lancet, vol. 387, no. 10019, pp. 703-716. DOI: 10.1016/S0140-6736(15)00954-X
Côté, A-M, Mallapur, A, Katageri, G, Ramdurg, U, Bannale, S, Wang, L, Magee, LA, Miller, S & Stones, W 2016, Measurement of proteinuria. in LA Magee, P von Dadelszen, W Stones & M Mathai (eds), The FIGO Textbook of Pregnancy Hypertension: An evidence-based guide to monitoring, prevention and management. The Global Library of Women’s Medicine, London, pp. 19-32.
Han, A, Helewa, M, Stones, W, Nathan, H, Miller, S & Magee, LA 2016, Hypertension. in LA Magee, P von Dadelszen, W Stones & M Mathai (eds), The FIGO Textbook of Pregnancy Hypertension: An evidence-based guide to monitoring, prevention and management. The Global Library of Women’s Medicine, London, pp. 1-18.
Magee, LA, von Dadelszen, P, Stones, W & Mathai, M (eds) 2016, The FIGO Textbook of Pregnancy Hypertension: an evidence-based guide to monitoring, prevention and management. The Global Library of Women’s Medicine, Carlisle.
Donald, I, Meyer, K, Gillespie, SH, Bowness, R & Brengman, J 2015, Project Sanitarium: gaming TB - A serious game for a serious problem. in 7th International Conference on Games and Virtual Worlds for Serious Applications, VS-Games 2015., 7295782, IEEE, Seventh International Conference on Virtual Worlds and Games for Serious Applications: VS-Games 2015, University of Skövde, Sweden, 16/09/15. DOI: 10.1109/VS-GAMES.2015.7295782
Boeree, MJ, Diacon, AH, Dawson, R, Narunsky, K, du Bois, J, Venter, A, Phillips, PPJ, Gillespie, SH, McHugh, TD, Hoelscher, M, Heinrich, N, Rehal, S, van Soolingen, D, van Ingen, J, Magis-Escurra, C, Burger, D, Plemper van Balen, G & Aarnoutse, RE 2015, 'A Step toward an Optimized Rifampin Dose Completed' American Journal of Respiratory and Critical Care Medicine, vol. 192, no. 4, pp. 525-6. DOI: 10.1164/rccm.201506-1061LE
O'Hare, BA-M, Phiri, A, Lang, H-J, Friesen, H, Kennedy, N, Kawaza, K, Jana, CE, Mulwafu, W, Heikens, GT & Mipando, M 2015, 'Task sharing within a managed clinical network to improve child health in Malawi' BMC Human Resources for Health , vol. 13 , 60. DOI: 10.1186/s12960-015-0053-z
Honeyborne, I, Lipman, MC, Eckold, C, Evangelopoulos, D, Gillespie, SH, Pym, A & McHugh, TD 2015, 'Effective anti-tuberculosis therapy correlates with plasma small RNA' European Respiratory Journal, vol. 45, no. 6, pp. 1741-1744. DOI: 10.1183/09031936.00221214
Boeree, MJ, Diacon, AH, Dawson, R, Narunsky, K, du Bois, J, Venter, A, Phillips, PPJ, Gillespie, SH, Mc Hugh, TD, Hoelscher, M, Heinrich, N, Rehal, S, van Soolingen, D, van Ingen, J, Magis-Escurra, C, Burger, D, Plemper van Balen, G & Aarnoutse, RE 2015, 'A dose ranging trial to optimize the dose of Rifampin in the treatment of tuberculosis' American Journal of Respiratory and Critical Care Medicine, vol. 191, no. 9, pp. 1058-1065. DOI: 10.1164/rccm.201407-1264OC
Gillespie, SH, Mendel, CM, Phillips, PPJ & REMoxTB Consortium 2015, 'Shorter moxifloxacin-based regimens for drug-sensitive tuberculosis' New England Journal of Medicine, vol. 372, no. 6, pp. 577-577. DOI: 10.1056/NEJMc1414718
Gillespie, SH, Ling, CL, Oravcova, K, Pinheiro, M, Wells, L, Bryant, JM, McHugh, TD, Bébéar, C, Webster, D, Harris, SR, Seth-Smith, HMB & Thomson, NR 2015, 'Genomic investigations unmask Mycoplasma amphoriforme, a new respiratory pathogen' Clinical Infectious Diseases, vol. 60, no. 3, pp. 381-388. DOI: 10.1093/cid/ciu820
International Federation Of Gynecology And Obstetrics, NV, International Confederation Of Midwives, NV, White Ribbon Alliance, NV, International Pediatric Association, NV, World Health Organization, NV & Stones, W 2015, 'Mother-baby friendly birthing facilities' International Journal of Gynecology and Obstetrics, vol. 128, no. 2, pp. 95-9. DOI: 10.1016/j.ijgo.2014.10.013
Bowness, R, Boeree, MJ, Aarnoutse, R, Dawson, R, Diacon, A, Mangu, C, Heinrich, N, Ntinginya, NE, Kohlenberg, A, Mtafya, B, Phillips, PPJ, Rachow, A, Plemper van Balen, G & Gillespie, SH 2015, 'The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations' Journal of Antimicrobial Chemotherapy, vol. 70, no. 2, pp. 448-455. DOI: 10.1093/jac/dku415
The Budget Advocacy Network (BAN), Sierra Leone 2015 'Three lessons from the Ebola crisis for Sierra Leone's government and investors'.
Heinrich, N, Dawson, R, du Bois, J, Narunsky, K, Horwith, G, Phipps, AJ, Nacy, CA, Aarnoutse, RE, Boeree, MJ, Gillespie, SH, Venter, A, Henne, S, Rachow, A, Phillips, PPJ, Hoelscher, M, Diacon, AH & Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA) 2015, 'Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients' Journal of Antimicrobial Chemotherapy. DOI: 10.1093/jac/dku553
Gillespie, SH, Oravcova, K & Monnier Hovell, Z, Respiratory Mycoplasma Infections, 2015, Digital or Visual Products, Henry Stewart, Online.
O'Hare, BA-M 2015, Malawi National Paediatric Guidelines - HIV in Children. in Malawi National Paediatric Guidelines.
Clar, C, Dyakova, M, Curtis, K, Dawson, C, Donnelly, P, Knifton, L & Clarke, A 2014, 'Just telling and selling: current limitations in the use of digital media in public health A scoping review' Public Health, vol. 128, no. 12, pp. 1066-1075. DOI: 10.1016/j.puhe.2014.09.009
Gillespie, SH, Crook, AM, McHugh, TD, Mendel, CM, Meredith, SK, Murray, SR, Pappas, F, Phillips, PPJ & Nunn, AJ 2014, 'Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis' New England Journal of Medicine, vol. 371, no. 17, pp. 1577-1587. DOI: 10.1056/NEJMoa1407426
Cooper, E & O'Hare, BA-M 2014, Infections in children-Worms. in D Southall (ed.), International Maternal and Child Hospital Health Care: a practical Manual for Hospitals Worldwide. Radcliffe Publishing, pp. 748-750.
Southall, D & O'Hare, BA-M 2014, Infections in children-Tetanus. in D Southall (ed.), International Maternal and Child Hospital Health Care: a practical Manual for Hospitals Worldwide. Radcliffe Publishing, pp. 660-662.
Parke, S, O'Hare, BA-M & O'Halloran, S 2014, The child presenting with a system or organ dysfunction-Haematological disorders-Anaemia. in D Southall (ed.), International Maternal and Child Hospital Health Care: a practical Manual for Hospitals Worldwide. Radcliffe Publishing, pp. 530-531.
Stones, W & Arulkumaran, S 2014, 'Health-care professionals in midwifery care' Lancet, vol. 384, no. 9949, pp. 1169-1170. DOI: 10.1016/S0140-6736(14)60857-6

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